ID A0A484BA19_DRONA Unreviewed; 1545 AA.
AC A0A484BA19;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN ORFNames=AWZ03_007999 {ECO:0000313|EMBL:TDG45568.1};
OS Drosophila navojoa (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG45568.1, ECO:0000313|Proteomes:UP000295192};
RN [1] {ECO:0000313|EMBL:TDG45568.1, ECO:0000313|Proteomes:UP000295192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG45568.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TDG45568.1};
RX PubMed=30423125; DOI=.1093/jhered/esy059;
RA Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT the mojavensis Cluster.";
RL J. Hered. 110:118-123(2019).
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDG45568.1}.
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DR EMBL; LSRL02000075; TDG45568.1; -; Genomic_DNA.
DR STRING; 7232.A0A484BA19; -.
DR OMA; ESDIGYR; -.
DR OrthoDB; 927694at2759; -.
DR Proteomes; UP000295192; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 6.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR PANTHER; PTHR24373:SF275; VASORIN; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00364; LRR_BAC; 8.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 22.
DR SMART; SM00013; LRRNT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 4.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000295192};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1545
FT /note="TIR domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019804312"
FT TRANSMEM 1066..1090
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1122..1255
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 256..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1368..1394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1374..1392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1545 AA; 172465 MW; CB405BFF472BFC86 CRC64;
MLNPLCQCLL LQLLLLIASG ISSQDAVTSH SESLSGSSKK HQQQTHSHSN AIMGEAGVSS
SQLLPPSTPA RTLRPISGGD AGLYDAPDDC HFMPAAGLEQ PEIALTCNLR TVNSEFDTTN
FSVIPAEHTV ALHILCNDEI MAKSRLEAQS FAHLARLQQL SIQYCKLGKL GRQVLDGLEQ
LRNLTLRTHN ILWPALNFEI EADAFAVTRQ LERLDLSSNN IWSLPDNIFC TLSALSALNM
SENRLQDVNE LGFRDRSKET ATSTETSSSS SSSSTTEAGK RAGSSCSLDL ELLDVSFNHF
VLLPANGFGT LRRLRVLHVN NNEISMIADK ALSGLKNLQV LNLSSNKIVA LPSELFAEQS
KTIQEVYLQN NSISVLSPQL FSNLDQLQAL DLSFNQITST WTDRNTFVGL IRLVLLNLSH
NKLTKLEPEI FSDLYTLQIL NLRHNQLENI AADTFAPMNN LHTLLLSHNK LKYLDAYALN
GLYVLSLLSL DNNALIGVHP EAFRNCSALQ DLNLNGNQLK TVPLALRNMR LLRTVDLGEN
MVTVLEENAF KGLGNLYGLR LIGNYLENIT MHTFRDLPSL QILNLARNRI AVVEPGAFEM
TSSIQAIRLD GNELSDINGL FSNMPSLLWL NISDNRLESF DYGHAPSTLQ WLDLHKNRLS
MLSNRFGLDA ELRLQTLDVS FNQLQRIGPA SIPNSIELLF LNDNLITTVD PDTFMHKTNL
TRVDLYANQI NTLDIKSLRI LPVHEHRALP EFYIGGNPFT CDCNIDWLQK INHITSRQYP
RIMDLETIYC KLLNNRERAY IPLLEAEPKH FLCTYKTHCF AVCHCCEFDA CDCEMTCPTN
CTCFHDQTWS TNIVECSGAG YSQMPRRVPM DTTELYIDGN NFVELAGHSF LGRKNLAVLY
ANNSNVAHIY NTTFSGLKRL LVLHLEDNHI VSLEGNEFHN LENLRELYLQ SNRIASIANG
SFQMLRKLEV LRLDGNRLMH FEVWQLAANP YLVEISLADN QWSCECGYLA RFRNYLAQSS
EKILDAARVS CIYNNATSVL REKNGTKCTL RDGVAHYMHT NEIEGLLPLL LVATCAFVGF
FGLIFGLFCY RHELKMWAHS SSCLLTFCYR SPRFVDQLDK ERPNDAYFAY SLQDEHFVNQ
ILANTLESDI GYRLCLHYRD VNINAYITDA LIEAAESAKQ FVLVLSKNFL YNEWTRFEYK
SALHELVKRR KRVVFILYGD LPQRDIDLDM RHYLRTSTCI EWDDKKFWQK LRLALPLPHG
RGNNNKRVTG CLAARTSSVN MYATAHEYQA GVGGVPVPVP VPASRIADKL YADCSSNNYA
TINECGARGY KPIPTSASAA AAACKFNTMN QLSKKQRELS VAGMAKTLEH HPHQQQSHQQ
QQQQQQQHRR SQHEYAVPAY LAAGQAPAYD SVDYAKQQLQ QRGSNCECIG TAKRAAKSQT
VSGAGGAGGA AGAGNGLPSS FSSNFVAPAA ISAGAYNCKK PCNCNADDEL LCGCGGLESG
TQSSATMSSS SNNSRQPELT HYESNLSLNE LDDGGASKPL HDLWA
//
