ID A0A484BBJ3_DRONA Unreviewed; 690 AA.
AC A0A484BBJ3;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Cation/H+ exchanger domain-containing protein {ECO:0000259|Pfam:PF00999};
GN ORFNames=AWZ03_007947 {ECO:0000313|EMBL:TDG45672.1};
OS Drosophila navojoa (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG45672.1, ECO:0000313|Proteomes:UP000295192};
RN [1] {ECO:0000313|EMBL:TDG45672.1, ECO:0000313|Proteomes:UP000295192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG45672.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TDG45672.1};
RX PubMed=30423125; DOI=.1093/jhered/esy059;
RA Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT the mojavensis Cluster.";
RL J. Hered. 110:118-123(2019).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|ARBA:ARBA00007367}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDG45672.1}.
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DR EMBL; LSRL02000073; TDG45672.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A484BBJ3; -.
DR STRING; 7232.A0A484BBJ3; -.
DR OMA; TVAHMWS; -.
DR OrthoDB; 3228646at2759; -.
DR Proteomes; UP000295192; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR31102; -; 1.
DR PANTHER; PTHR31102:SF22; NA[+]_H[+] HYDROGEN ANTIPORTER 1, ISOFORM A; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000295192};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 200..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 600..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 232..612
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..690
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 690 AA; 75314 MW; 5CAEB5A77224C032 CRC64;
MTANGEPGAN SDESSLNTLP LPDIRTSPMP NGNSNSSHKS STVIESQPKR RVSIIADPPM
IGGASGGAAG YDNLAYEQNP RRKISQTSTH SHTEIGPARR RSILKEPSLH TNDNESDRGS
THSYENYRQS ALDVLNAKYQ GHQHQPPQSQ DGANYVEDSW IYTFCLKCRG EEPSESWEPS
FWQKVFPYPL CPTFRTFSRL IVLILIGLLL WIVAFVIIGD TAAPGGQLFS LVVLTVAANF
GGYIISLTTL PRLIGMLLVG ILFQNVGWVD LEGDFSKVTG HLRKFALTII LTRAGLEMEP
EAFKKVYKTI LKLGIVPWIV EAAVMTVMSH YLLDLPWMWG CLLGSIIAAI SPAVVVPCLF
RLRTKGYGVV KGIPTLVVAV AGVDDALSVA IFGIISTIMF SDKGVGYQIA QAPVCILGGL
AFGVIWGSIA RIFPEKGDAY VVPLRTLMLF AGNLVAIYGS EELGFEGLGP LGVVFSSFVS
NLFWCKDGWD VDDNPVSTAF EIFWMIFEPI LFGLTGATIK IDELDSHTVS IGAACIFAGV
VIRIFITAGI AVGDRLNTKE KFFVGLSWMA KATVQAALGP VALKNLGSDA TAEERKWAEI
VQTVCVFSIV LTAPLGAILI SITGTRMLKK TKQPQILTGW RRSHRPSIRD ISIIDEEEER
EDPETPRDKE TDDNTQSNAH LTNLSYTANK
//
