ID A0A484BDQ9_DRONA Unreviewed; 555 AA.
AC A0A484BDQ9;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=AWZ03_007635 {ECO:0000313|EMBL:TDG45915.1};
OS Drosophila navojoa (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG45915.1, ECO:0000313|Proteomes:UP000295192};
RN [1] {ECO:0000313|EMBL:TDG45915.1, ECO:0000313|Proteomes:UP000295192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG45915.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TDG45915.1};
RX PubMed=30423125; DOI=.1093/jhered/esy059;
RA Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT the mojavensis Cluster.";
RL J. Hered. 110:118-123(2019).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDG45915.1}.
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DR EMBL; LSRL02000068; TDG45915.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A484BDQ9; -.
DR STRING; 7232.A0A484BDQ9; -.
DR OMA; KHEYEDD; -.
DR OrthoDB; 3521961at2759; -.
DR Proteomes; UP000295192; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.132.10; -; 1.
DR Gene3D; 2.170.11.10; DNA Topoisomerase I, domain 2; 1.
DR Gene3D; 1.10.10.41; Yeast DNA topoisomerase - domain 1; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013034; DNA_topo_DNA_db_N_dom1.
DR InterPro; IPR013030; DNA_topo_DNA_db_N_dom2.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR025834; TopoI_C_dom.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR014727; TopoI_cat_a/b-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR InterPro; IPR008336; TopoI_DNA-bd_euk.
DR InterPro; IPR036202; TopoI_DNA-bd_euk_N_sf.
DR InterPro; IPR013499; TopoI_euk.
DR PANTHER; PTHR10290:SF23; DNA TOPOISOMERASE 1; 1.
DR PANTHER; PTHR10290; DNA TOPOISOMERASE I; 1.
DR Pfam; PF14370; Topo_C_assoc; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR Pfam; PF02919; Topoisom_I_N; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SMART; SM00435; TOPEUc; 1.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF56741; Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000295192};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 208..526
FT /note="DNA topoisomerase I eukaryotic-type"
FT /evidence="ECO:0000259|SMART:SM00435"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 64755 MW; D41964F980910D36 CRC64;
MSDTYIDTCG DPTESEGDKK PPVGGPKVRC RFVPQKFRNL KGHWQSCLRP RPSVAEKPIC
MKPKWQTLRH NGPCFPADHE RLPEDVKFYY DNCPVELTEQ AEEVATFYAK LMKTAFVQMR
DFNQNFFNEF RSCLSEEQRL YITCFELCNF SDISQYLECQ RENEKERIAE ENKLYGYCLV
DGESRRITQF RISRPGLCCP RHGFSTTMGT IRPRVLPEDV VINCDESEEP PAPPCGHLWA
AVVHDRTVRW VYAWHDIVTG CMHHAYPRNE SSRRSRPPRR DVLDTARRLQ QHLQTIRDEY
ENLLSSWNWL VRQRSVALYC IDRLAMSCDA EEVPAETTVC GLCVQNIKLC PKLGGQRNVL
QLLAGNRDCR QREYKRSSVP AEIFYNLSVF VSSKQPEELV FEELTTETLN EHLDFLMDGL
TSSVFRICNA SRLLENRLVK IPLSATLCEQ LTAYNKALKA VHMNCGFRHR RIDPLPALKR
PCLIPRNRAA EQRKLRLIRL QTKPLVEATF YYLDPRITIS WCLRRDIPLS SIYLNYSMRK
KLFWATQCTT QYFAF
//
