ID A0A484BIK2_DRONA Unreviewed; 929 AA.
AC A0A484BIK2;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
DE Flags: Fragment;
GN ORFNames=AWZ03_004798 {ECO:0000313|EMBL:TDG48686.1};
OS Drosophila navojoa (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG48686.1, ECO:0000313|Proteomes:UP000295192};
RN [1] {ECO:0000313|EMBL:TDG48686.1, ECO:0000313|Proteomes:UP000295192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG48686.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TDG48686.1};
RX PubMed=30423125; DOI=.1093/jhered/esy059;
RA Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT the mojavensis Cluster.";
RL J. Hered. 110:118-123(2019).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDG48686.1}.
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DR EMBL; LSRL02000030; TDG48686.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A484BIK2; -.
DR STRING; 7232.A0A484BIK2; -.
DR OMA; LSTCWCL; -.
DR Proteomes; UP000295192; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00112; LDLa; 9.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 9.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF8; VERY LOW-DENSITY LIPOPROTEIN RECEPTOR; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 9.
DR Pfam; PF00058; Ldl_recept_b; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 9.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 9.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 5.
DR PROSITE; PS50068; LDLRA_2; 9.
DR PROSITE; PS51120; LDLRB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000295192};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 559..599
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 693..736
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 737..779
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 780..823
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 824..868
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 232..244
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 239..257
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 292..307
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 333..348
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 352..364
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 359..377
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 371..386
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 399..417
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 411..426
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 478..490
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 485..503
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 497..512
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 529..547
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT NON_TER 929
FT /evidence="ECO:0000313|EMBL:TDG48686.1"
SQ SEQUENCE 929 AA; 102312 MW; D2DAB3F4F4EBC558 CRC64;
MDELPVTADT AAITIDISDS NNNSNSNNNN SNCNSSNAVD TPPKVSAFFS SSSNYQSRVQ
QLISFSFTSS FHLIFITSIL SISKFCNAAA MNAAQVTASA PSPSLIMSNL SGSALLERIM
KTTTLGPQLD KLKSSAPAAA NSISGSSASG NSFGSSFFNS KGINFSFQNV SGKINTPLDI
SQSLPHYCEE KQFHCKQSGE CIPIRFVCDG EIDCKDHSDE LIEQCKFKES TCGTEQFRCN
NGKCIPNKWR CDRESDCADG SDEAPGLCMN VCNHHTFRCH NGEQCLPRSW LCDGDPDCRD
GSDELECKSK TCSPDEFACK SGEGECIPLA WMCDQSKDCS DGSDEATCNI TCRSDEFTCN
NSRCIQKRWV CDQDNDCGDG SDELACPKVE CPKNTSYTCS NGACISKTWV CDGEEDCEDG
GDERGCGAVS QTITPCQPNE FQCRDRITCL HQSWVCDGDR DCPDGDDEYA SSCKNVTCRP
DQFQCGDRSC IAGHLTCNGQ TDCADGSDER DCRVSAEPKR CNATSQFDCG GGQCIALSQV
CDRRKDCPDG EDEPANKCGI NECEVSNGGC MHRCVDQPVG YRCECHAGYK LASDGHHCMD
INECEEPGVC SQICVNEVGG FKCECEAGYM RDSHNRTRCK ATEGHASLLL ARRHDIRKIA
LDHMEITSIV NNTKSATALD FSATALDFVF RTGMIFWSDV TTQSIYKAPI DEGNEKTVVL
KKSSVTSDGL AVDWIYNHVY YTDTHKCTIE LTNFDGNMGK VLIEDALDIP RSIALDPIEG
WMYWSDWGAS PRIERAGMDG SHRTTIINYD VKWPNGITLD LVRKRIYWVD GKLNIISSAN
YDGSQRRQIL YSTEYLRHPF SITTFEDYVY WTDWDKQTPD GINHCQSVNG HCSHLCLPAP
RINERSPRIS CACPTGLKLM PDGLMCVED
//
