ID A0A484BIZ8_DRONA Unreviewed; 1998 AA.
AC A0A484BIZ8;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AWZ03_004869 {ECO:0000313|EMBL:TDG48757.1};
OS Drosophila navojoa (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG48757.1, ECO:0000313|Proteomes:UP000295192};
RN [1] {ECO:0000313|EMBL:TDG48757.1, ECO:0000313|Proteomes:UP000295192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG48757.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TDG48757.1};
RX PubMed=30423125; DOI=.1093/jhered/esy059;
RA Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT the mojavensis Cluster.";
RL J. Hered. 110:118-123(2019).
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC6 subfamily.
CC {ECO:0000256|ARBA:ARBA00006793}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDG48757.1}.
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DR EMBL; LSRL02000030; TDG48757.1; -; Genomic_DNA.
DR STRING; 7232.A0A484BIZ8; -.
DR Proteomes; UP000295192; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR CDD; cd17936; EEXXEc_NFX1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR19306; STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6; 1.
DR PANTHER; PTHR19306:SF6; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF13476; AAA_23; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000295192}.
FT DOMAIN 479..707
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 719..890
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT DOMAIN 977..1253
FT /note="Rad50/SbcC-type AAA"
FT /evidence="ECO:0000259|Pfam:PF13476"
FT REGION 890..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1735..1754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1162..1382
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 914..928
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1998 AA; 231216 MW; 3ABE99C473DB3BB2 CRC64;
MVELFGEDYD CWEWFQADKE KILRSLTRKN ANERHQVQGQ RRHCNYWNRA RAVVPSKIPT
DGLQEILNLQ PLGMFLYLAT EIEPNFFIDQ IGANDNIDRV LIYTRILVTL CELELPGFHN
DMLSKFAACT PLIEHYEELV RKLCTKSYRT MWTDMNRVDS IISNMQTLLL QAQRADVLDE
NGMDILFKIW TNLKNNNNPI IEERPICQEF LERLHGLFAV DLDTLSAPNP AAEIYPSLEE
LKQWLNENGE TSIHAAKLTM SFTNTTHYIN SQRLFLRQQF LIPLRELVRR IHSKRNLQNL
MPLQIAFEGV QIKLNNNFSN AHNSKLLFVD ILAMQRKNTS NQDVQCEKSL EEALLRLKNG
TLLCFTTSYD FNNLILAIMV NTDAKQLRQG YISIAIVRQF DIGNIYGKFL IMFETPVYFE
PYQKAYRYLT NSNVINFPMS DYIVHGLTRT KSPAYLNHTQ PPKVYESQKF INKLRKMPLN
LSQHDAFQRA LNTNFNLIQG PPGTGKTHMC LQLIKTILEH AKFCAPIVVV TYTNDTLDKF
LMKLSSFTSS IVRFGSQSRL PEIAKFNYRA DTNTHMINPR LKRLYWMVNL EIKEHFQRLQ
TLYSDFNDTD KAYSDILATQ RLIWNAQEKL ECIRMIFQHY LIIKKNVLAM TTTCAARMNF
VFRFLKTRIV IFEEAAEILE AHILPCLTPY TEQVIMIGDH MQLKPYISYI RGLKSSTQSH
SLFERLIRSN FQVNVLNIQY RMRNTFAELL CPVIYEKLIS HDSVYNFPSV RNMGLNLYFL
QHQEPETHIL DGFLYNEYET KKVAEIVHHL VEVSGYRHKD VVVLSPYTLQ VESIKKKLSK
KPNLKEVFVT TVDSFQGLEA DIIVLSLVRS NTNANIGFLN EQNRICVAMS HKPKMRRSRT
RNKNLSTESD SDSSISPPKK KKSKRSSGTN EGDGMLVEAS TSRAVRKRTT NANSSCEEPS
YGLAPPNAFA SCGKIISIRL KNFMCHSHLY IEFGPNINFL VGSNGSGKSA VIAALALGLA
GSARNTSRAS SIQKLIKNGE TNASIELTLS NVGHRPFKPD IYGPHITVVR QIRQSSSTYE
IKDSHHRTVS RKLDEIRRMI LYFGISVENP IFVLNQEASR EFLKDLEPAS NYKLFMKATQ
LDLCANSLTQ CHERREHINY DVQLLKMKLQ KLKSLCHEEE EKLAIIKNEE ALKIKLKEAT
TMLAWVKVSH IQDDLTKIEQ TLKIIEKKNA DLSQKTTQKT STQESIAHAL QELEQTKQRI
MEKYQAQENA LRAAKRIAQD CLLKASSFKA SIKNVEKRLR EEQTNFEGCQ KHMNNYHADY
SEVKRLREEN AATLATLKEK VAQRNELIAR LRDEQSELRN RLTAARENLE STKNEITKLH
KMEQSLQWEM ESLLRNKSNK MSVYGEHAME VANALRAQYS GSNASQMPRG PIGMYITVPN
PKYRDLIENQ LSHCLRSYIV SSDKDRMSLR ALLQKSYAGG NIPTIVTSPF TNRVYNVSKY
KVQCRSSNTT VLMDEIRCED PVVMNYLIDT LRIETVLLTD SKETAESLTS TVENVPPNLT
RILVPSLGLE YCPSPNYAMY SIQISPARFI QVNVDDRIRQ LKTEQNSLQE RVANLQPHYA
KAKLKLETDT REISAKSDMI KAHHTENTTA MKQIMDIENF EYREFPAFDV LETHLTTSRE
KIEKLKEERN ILENQLQEIA ERNDQANEET KKEQGILDSL NKKISEIDAK SQELQSRARD
LDRHFEENQR RLKQTDELLK TTKKDKKDKE AELEAARQEA QKVGEFIETN KSEENIRDQI
SRYKAKIKHF ESMKLNSEEV EQKLSKLRDL LKTESDILNN ILCVVEKLRI EYHSRAQRFQ
RSRHHFFTMV EFHFKQALIC RQFEGYLEPN HKDKTLKISV YPPSGNKTSN MRSLSGGERS
FTTVSLLKGL WSTSSHPFYF LDEYDVFTDE VNRTFITKLL IQEGIDFPNR QYCFLTPQDT
KVDANHLITV HKLERPDR
//
