ID   A0A484BMJ8_DRONA        Unreviewed;       570 AA.
AC   A0A484BMJ8;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   RecName: Full=asparaginase {ECO:0000256|ARBA:ARBA00012920};
DE            EC=3.5.1.1 {ECO:0000256|ARBA:ARBA00012920};
GN   ORFNames=AWZ03_004560 {ECO:0000313|EMBL:TDG49075.1};
OS   Drosophila navojoa (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG49075.1, ECO:0000313|Proteomes:UP000295192};
RN   [1] {ECO:0000313|EMBL:TDG49075.1, ECO:0000313|Proteomes:UP000295192}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG49075.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:TDG49075.1};
RX   PubMed=30423125; DOI=.1093/jhered/esy059;
RA   Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT   "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT   the mojavensis Cluster.";
RL   J. Hered. 110:118-123(2019).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TDG49075.1}.
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DR   EMBL; LSRL02000027; TDG49075.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A484BMJ8; -.
DR   STRING; 7232.A0A484BMJ8; -.
DR   OMA; NCVCYLI; -.
DR   Proteomes; UP000295192; Unassembled WGS sequence.
DR   GO; GO:0004067; F:asparaginase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009066; P:aspartate family amino acid metabolic process; IEA:UniProt.
DR   CDD; cd08963; L-asparaginase_I; 1.
DR   Gene3D; 3.40.50.40; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR   Gene3D; 3.40.50.1170; L-asparaginase, N-terminal domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR036152; Asp/glu_Ase-like_sf.
DR   InterPro; IPR006034; Asparaginase/glutaminase-like.
DR   InterPro; IPR040919; Asparaginase_C.
DR   InterPro; IPR027473; L-asparaginase_C.
DR   InterPro; IPR041725; L-asparaginase_I.
DR   InterPro; IPR027474; L-asparaginase_N.
DR   InterPro; IPR037152; L-asparaginase_N_sf.
DR   PANTHER; PTHR11707:SF28; 60 KDA LYSOPHOSPHOLIPASE; 1.
DR   PANTHER; PTHR11707; L-ASPARAGINASE; 1.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF00710; Asparaginase; 1.
DR   Pfam; PF17763; Asparaginase_C; 1.
DR   PIRSF; PIRSF001220; L-ASNase_gatD; 1.
DR   PIRSF; PIRSF500176; L_ASNase; 1.
DR   PRINTS; PR00139; ASNGLNASE.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM00870; Asparaginase; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF53774; Glutaminase/Asparaginase; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 3.
DR   PROSITE; PS50088; ANK_REPEAT; 3.
DR   PROSITE; PS51732; ASN_GLN_ASE_3; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Reference proteome {ECO:0000313|Proteomes:UP000295192}.
FT   DOMAIN          60..197
FT                   /note="L-asparaginase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00710"
FT   DOMAIN          220..325
FT                   /note="Asparaginase/glutaminase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17763"
FT   REPEAT          412..444
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          445..470
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          511..543
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ   SEQUENCE   570 AA;  63250 MW;  8BCD612A9C313397 CRC64;
     MMRMDDGSLA NVSGELIKRL REDTSCHDKN YKLPFERGEN SPLVLPHIHD TQYRVIYDIV
     EFSPLMNSSS IHVDDWVHLA KEVDDNYERY DGFVILHGRD TMAFTASALT FMLENLTKPV
     VLTGSQLPII ELRTDGRNNF ITSLLIAGNF DLPEVILVFG HRVLRGCRST KRANNSFHAF
     DSPNAPSLGT CSVSIDIDNK GIFHSNSSGP FTVFTEMEPN VSLLRLYPGI SVEVMQTFFK
     PPMKGVVIQS YGIGNIPTKD RKLSDIISDA ISRGVVVVNM TQCPNGKVMP QHLTSNWMEL
     GVVCAYDMTQ EAALTKLSYV LGKKEWDINV KKEKMEQSLR GELTIPKSAK SNEVDLVEGV
     ARDLQVSSDK KRDEMCATFF PALVDAAIRE DNPQKLTNLK QYGANLSDTN TEGRTALHLA
     CFLGKKNCVR ALLKDGSPVD LTDRFNRTPL HEAIDADNHE LIDVLLKKGA ALTEDPLELA
     EKLRSLAEHG NVDRLESYRL AGADLEVADG TGRTALHHAS QLGKINVVKY LLPYYRNPSA
     KDCLGLCAIQ YAKAGNFCNI VALLSADKNC
//