ID A0A484BPW1_DRONA Unreviewed; 1738 AA.
AC A0A484BPW1;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Endonuclease {ECO:0008006|Google:ProtNLM};
GN ORFNames=AWZ03_003701 {ECO:0000313|EMBL:TDG49925.1};
OS Drosophila navojoa (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG49925.1, ECO:0000313|Proteomes:UP000295192};
RN [1] {ECO:0000313|EMBL:TDG49925.1, ECO:0000313|Proteomes:UP000295192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG49925.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TDG49925.1};
RX PubMed=30423125; DOI=.1093/jhered/esy059;
RA Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT the mojavensis Cluster.";
RL J. Hered. 110:118-123(2019).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the DNA/RNA non-specific endonuclease family.
CC {ECO:0000256|ARBA:ARBA00010052}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDG49925.1}.
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DR EMBL; LSRL02000019; TDG49925.1; -; Genomic_DNA.
DR STRING; 7232.A0A484BPW1; -.
DR OMA; LMRSEHE; -.
DR Proteomes; UP000295192; Unassembled WGS sequence.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd00091; NUC; 1.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 3.40.570.10; Extracellular Endonuclease, subunit A; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR018524; DNA/RNA_endonuclease_AS.
DR InterPro; IPR001604; DNA/RNA_non-sp_Endonuclease.
DR InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf.
DR InterPro; IPR020821; Extracellular_endonuc_su_A.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR044925; His-Me_finger_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR PANTHER; PTHR13803:SF4; SECRETORY 24CD, ISOFORM C; 1.
DR Pfam; PF01223; Endonuclease_NS; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SMART; SM00892; Endonuclease_NS; 1.
DR SMART; SM00477; NUC; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF54060; His-Me finger endonucleases; 2.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
DR PROSITE; PS01070; NUCLEASE_NON_SPEC; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022759};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000295192};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 86..299
FT /note="DNA/RNA non-specific endonuclease"
FT /evidence="ECO:0000259|SMART:SM00892"
FT DOMAIN 87..299
FT /note="Extracellular Endonuclease subunit A"
FT /evidence="ECO:0000259|SMART:SM00477"
FT REGION 516..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..707
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..801
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..872
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..949
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1738 AA; 191675 MW; C8A2D11042B839D9 CRC64;
MRRLWHLLGV AFGLASAVGC FLAGVYFQHT HATRQLQQLV QQDVYAYYIS PKIFAAFGFF
NVPNGTPNHV QRIMKYGFPG LDDVRLYSDF VLSYDRRNRV AHWVCEHLQL ANLQGARGVG
RASATYRADL SVPSNFRSTL ADYKHSGFDR GHLAAAGNHR GQQVHCNETF LLTNIAPQIG
QGFNSGAWNK LEIYVRELAQ SFGSVYVCTG PLFKPRAQGN RKWTVEYQMI GENMVAVPTH
FFKVIMVESR LPLGKPYMEA YVLPNAPIPN QSTLRDFLCD IREIEHFAGL HFFQGMRRSA
IFGSNYPNPG AQSCAFYALA GLTGFVFGAY FQQESAIRQL FWMIKTDPYV FHHRRKLYPL
VSTFRTDHED RLWNRSKCLT SKIRDRLIYA LFDMFNSIFF DKRPESLSPD LLDLIKYGLP
STENLYVHKD YVVSQDLSTN APKWMCEHLK GNYRKLTTEA DGDALHLRYN DVYVLSCGAT
RVCKAFKREI WRKLEEHVSQ MTEKYHSVPI YKEMNPNMYG PPSTQFQPQY PAGPPRGPTG
WPSQQQQQQQ QQQPLQSQPP PQQQQPHQQP LQQPPTQQQQ QQYGAPVTSA QQPYVNGNYQ
QQLTTSMSGL SVSGNPLKPS QPPVGMPTAA VSAPVAAPSG PFNQFNSNAP PTSQPMPPAS
SGMNFNNNNN AYAAAYANGS TGPSPSPAPP VSAAAAGPSP SPAPSMYPPS SAASTMAQQT
SAPGTMPQNV PGGVNQMTLN SASLAGLPHM PPKSSTQQLP PTSTAPGQPL PPVSQAGGYG
RPGQPQMPPG PAAPAAFTQP GMPPQRPAAG VAPAAAFTQP GMVTQPPAAG GQNSNPYGVP
PPGNFQGSYA GQPAPGPGPV QGAYPGAPPL PGQQAGPQQF GAAPPQPVGY PPQPGQQLQQ
PSMPGYPPQP MPGYPPQAGQ QPQQPMPGYP PQPGSYPGQP GPGRPGYNQP PMPGAGSMYQ
QAPPRRLDPD QMPNPIQVMI ENQQAAGGIF VTNQPGLLPP LVTTKFVVND QGNSSPRFIR
SSLYCIPNTG DLLKTTALPL TLNISPLARI GKGEMEPPIV NFGDMGPIRC NRCKAYMSPN
MQFVDAGRRF QCLMCKVTTE VHPDYYQHLD HTGQRVDKHE RPELLLGTYE FLATKDYCRN
NTAPEVPAFI FIIDVSYNTI KSGLVHLLCS QIKNILKHLP VDQGQDKSKV RVGFITYNST
VHFYNIKSSL AQPQMMVVGD VQEMFMPLLD GFLCHPEESA AVIDALMEEI PRMFVDTKET
ETILYPAIQA GLEALKASNA SGKLLVFNST LPIAEAPGKL KNRDDRKLLG TDKEKTVLTP
QTTVYNQLGQ ECVQQGCSVD LFVFNNAYID IATIGQVSRL TGGEVYKYTY FQAELDGKRL
IEDIIKNVSR PIAFDAVMRV RTSAGIRPTE FFGHFYMSNT TDVELASIDA TKSVSIEIKH
DDKLAPEENV YLQVALLYTS CSGQRRLRIL NLALRVTVTI ADVFKSCDLD AMMLFFAKQA
CFKLMEHSPK QVKDNLIQRS AQILACYRKH CTSPTSAGQL ILPECLKLLP LYASCLLKND
AVSGGSDMTL DDRSYVIQFV LAMDLNMSVN YLYPRFIPIH NVDVDESSLP TPVRCTHEKI
TEDGAYILEN GVHLFVWLGQ SLSPTFVQSV FGVQCTQQVN AERFAIAADT PLARRITGII
DQIMAERTRY MRVTCVRQND KLESVFRHFL IEDRGTDGSA SYVDFLCHMH KEIKDLLS
//
