ID A0A484BQX6_DRONA Unreviewed; 1209 AA.
AC A0A484BQX6;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN ORFNames=AWZ03_003049 {ECO:0000313|EMBL:TDG50460.1};
OS Drosophila navojoa (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG50460.1, ECO:0000313|Proteomes:UP000295192};
RN [1] {ECO:0000313|EMBL:TDG50460.1, ECO:0000313|Proteomes:UP000295192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG50460.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TDG50460.1};
RX PubMed=30423125; DOI=.1093/jhered/esy059;
RA Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT the mojavensis Cluster.";
RL J. Hered. 110:118-123(2019).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDG50460.1}.
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DR EMBL; LSRL02000015; TDG50460.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A484BQX6; -.
DR STRING; 7232.A0A484BQX6; -.
DR OMA; YRETKYI; -.
DR Proteomes; UP000295192; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR01177; GABAB1RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000295192};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1209
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019726651"
FT TRANSMEM 447..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 621..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 662..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 447..670
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 898..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1129..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..938
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..991
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1035..1053
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1209 AA; 137378 MW; 478DD131975AAC7D CRC64;
MFQPNLILSL LLCLGLCLSR AQARTAKRSD VYIAGFFPYG DGVENSYTGR GVMPSVKLAL
GHVNEHPQIL TNYRLHMWWN DTQCNAAVGV KSFFDMMHSG PNKVMLFGAA CTHVTDPIAK
ASKHWHLTQL SYADTHPMFT KDAFPNFFRV VPSENAFNAP RLALLKEFNW TRVGTVYQNE
PRYSLPHNHM VADLDSMELE VVETQSFVND VAESLKKLRE KDVRIILGNF NEHFARKAFC
EAYKLQMYGR AYQWLIMATY TTDWWNVTLD SECTDKEIAT ALEGAILVDL LPLSTSGDIT
VAGITADEYL VEYDRLRGTE YSRFHGYTYD GIWAAALAIQ YVAEKREDLL THFDYRVKDW
ESIFLEALRN TSFEGVTGPV RFYNNERKAN ILITQFQLGQ MEKIGEYHSQ QAHLDMTLGK
PVRWVGKTPP KDRTLIYIEH SQVNPTIYIV SASASVIGVI IATVFLAFNI KYRNQRYIKM
SSPHLNNLII IGCMLTYLSI IFLGLDTTLS SVAAFPYICT ARAWILMAGF SLAFGAMFSK
TWRVHSIFTD LKLNKKVIKD YQLFMVVGVL LAIDIAIITT WQIADPFYRE TKQLEPKHHE
NIDDVLVIPE NEYCQSEHMT IFVSIIYAYK GLLLVFGAFL AWETRHVSIP ALNDSKHIGF
SVYNVFITCI AGAAISLVLS DRKDLLVELK RNPQGVVDKR VRATLRPMSK NRRDSSVCEL
EQRLRDVKNT NCRFRKALME KENELQALIR KLGPEARKWI DGVTCTGAPT DMEPILSDDM
AKLSAPPVRR EMPSTTEVTE LTSVDSITST HVEIDNSFVS VQSTTVAPSL PPKKKKQSIV
EHPPSAMMQP IQQQLQQHLQ KQQQMQQQQQ LQQQQQQQQQ QQHQQQQQQQ QQQQQQQQQQ
QQLHQHHRHL EKRNSVSAQT DGNIGSVTSS SSTKRPTGDC SAMRDRRQST VSRHYESGSQ
TPTAKPKYSS THRNSSTNIS TSQSELSNVC PHSKPGTPGV IKTPTASDHR RTSMGSALKS
NFVVSQSDLW DTHTLSHAKQ HSRQSQRTYA SPQRCSEHHG HVMPYEQSTT SPIQRSVSEK
NRNKHRPKPQ KGTVCQSETD SEREREPTPT SVQQCTQTRK FNRNANIQHA AHHHSSPNVA
PEKQRKQRNR TDHSIYGASS ETELIEGETA ILPIFRKLLT EKSPNYRGRS AVGQSCPNIS
IKCDIVEYL
//
