ID A0A484BR33_DRONA Unreviewed; 133 AA.
AC A0A484BR33;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Insulin-like domain-containing protein {ECO:0000259|SMART:SM00078};
GN ORFNames=AWZ03_003230 {ECO:0000313|EMBL:TDG50325.1};
OS Drosophila navojoa (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG50325.1, ECO:0000313|Proteomes:UP000295192};
RN [1] {ECO:0000313|EMBL:TDG50325.1, ECO:0000313|Proteomes:UP000295192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG50325.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TDG50325.1};
RX PubMed=30423125; DOI=.1093/jhered/esy059;
RA Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT the mojavensis Cluster.";
RL J. Hered. 110:118-123(2019).
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds. {ECO:0000256|ARBA:ARBA00011207}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDG50325.1}.
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DR EMBL; LSRL02000016; TDG50325.1; -; Genomic_DNA.
DR RefSeq; XP_017956337.1; XM_018100848.1.
DR AlphaFoldDB; A0A484BR33; -.
DR STRING; 7232.A0A484BR33; -.
DR GeneID; 108651282; -.
DR KEGG; dnv:108651282; -.
DR OMA; VYDECCV; -.
DR OrthoDB; 3028803at2759; -.
DR Proteomes; UP000295192; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd04366; IlGF_insulin_bombyxin_like; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR040228; Insulin-relat-peptide_inver.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR13647:SF4; INSULIN-LIKE PEPTIDE 1-RELATED; 1.
DR PANTHER; PTHR13647; INSULIN-LIKE PEPTIDE 2-RELATED; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Reference proteome {ECO:0000313|Proteomes:UP000295192};
KW Secreted {ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..133
FT /note="Insulin-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019723150"
FT DOMAIN 49..132
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
SQ SEQUENCE 133 AA; 14772 MW; 5793ABD927EE7EA8 CRC64;
MLYAPHATAT GQRQRRRQRL CLLLLLLIAL GSCCCSASNI AQLLREGKHK LCGPALNEAM
DMVCVNGYNT IPMERDLELA PSHQGFALSP LLSSLYGAEV LIKTRRLRRQ GGGIYDECCR
NSCTRSELLA YCR
//
