ID A0A484BSY1_DRONA Unreviewed; 1118 AA.
AC A0A484BSY1;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:TDG50871.1};
GN ORFNames=AWZ03_002860 {ECO:0000313|EMBL:TDG50871.1};
OS Drosophila navojoa (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG50871.1, ECO:0000313|Proteomes:UP000295192};
RN [1] {ECO:0000313|EMBL:TDG50871.1, ECO:0000313|Proteomes:UP000295192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG50871.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TDG50871.1};
RX PubMed=30423125; DOI=.1093/jhered/esy059;
RA Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT the mojavensis Cluster.";
RL J. Hered. 110:118-123(2019).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDG50871.1}.
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DR EMBL; LSRL02000013; TDG50871.1; -; Genomic_DNA.
DR RefSeq; XP_017960580.1; XM_018105091.1.
DR AlphaFoldDB; A0A484BSY1; -.
DR STRING; 7232.A0A484BSY1; -.
DR GeneID; 108654049; -.
DR OMA; IGFFKPH; -.
DR OrthoDB; 4246085at2759; -.
DR Proteomes; UP000295192; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:UniProt.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF83; INTEGRIN ALPHA-PS3-RELATED; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000295192};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 26..1118
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5019613374"
FT TRANSMEM 1061..1084
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 113..174
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 335..397
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 399..455
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 462..524
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 510..647
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 651..772
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT REGION 243..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1118 AA; 123946 MW; 472125FF4058CF38 CRC64;
MAWQGREVVL GLLLAAACLA GSACAYNLSP RPNREIRDPQ FATAMPKVRA SYFGFSLNLR
PHGIFVGAPQ AQSTLEAQRK VNETGAIYKC SLLNGTCSPY VFDGNGNRNI ENTEYTWDSE
RRDFQWLGGS MDGGTRDGDK LLVCAPKFIA PSSKDYHMHG ICYWVADTLA DQPQNVTKIS
PLRLKTEQVK EDDNHRYYFY ILAEEGLSAH VSDDGEQFLI GAPGIYTWRG SVIRYRKVTQ
VDDPSASRRD TSSQRRRKSR GSGDYIDYAP EVYYKTDIPN PQKWGQSDDS YFGYSVGSGY
FDSTNLKRLL YVATAPQANE QSGEAYIFDI RGSNIESFHI FRGEQFGEYF GYAVLAEDLN
GDNLTDVIIS GPQHAVEDSH DNGAIYVFVN KGRFNFEMKQ LLCPPPVTAK ARFGTTLTRL
GDINHDGYND IAVGAPFAGN GSVFIYLGSE SGLRDKPSQR LDSPQQEPSK YGQHMFGHGL
SRGSDIDGNG FNDFAVGAPN AEAVFLYRAY PVVKILATVR SQNREIKPDQ NRVQITACYG
LSTTAKGSSA QQQEIAMKLV IDAQLKRATF TQSQSSELSF NAMAGTTQQC RVFDCEVRYS
EKDIFQPIQL EMHYELTKKV PDSEVFCDTC VAVDPDDPKV YSEKIIFSTG CATDVCIADL
KVTAKDLSSS YILGSGKTLR INYEVTNNGE TAYLPQLNVT SSSRLNFAQI PGNCRVSDAV
MLCDLNHGRP LGKGDKDGIT ISFDVSSLTG KALTISAEVF STGHEQNPSD NKLVSLIALK
EYTEIDASGG QTNEAINLEH YKNSAVIVNN YEIKSNGPSN VDALELVFQI PVAYKIAGST
ATIPIINVGN ITMQATYDAQ LVAIELLDPN NTQIIMNPIE ISTTRTSKHT ERVVVSQNGA
HYDVSSSAHT EQSWQELDSD SVATASMTRK RRDLKALTAN REQYARISNV KAHELLSEDF
KGKLPVNRTI VFNCRDPEMT ICLRAVMRVY NFKPEKPINL NMRYSVDLNE VNAILIDPWE
FFAILIDLSV RKEGDPTGSS LLIRRKIEPN VISKHLVTKS LIWIIILSVL GGLVLLAVFT
YGMYKMGFFK RTKKDELDKL VHQGAVEPEA ENLNSGNN
//
