ID A0A484BU58_DRONA Unreviewed; 897 AA.
AC A0A484BU58;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=SWIRM domain-containing protein {ECO:0000259|PROSITE:PS50934};
GN ORFNames=AWZ03_002378 {ECO:0000313|EMBL:TDG51291.1};
OS Drosophila navojoa (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG51291.1, ECO:0000313|Proteomes:UP000295192};
RN [1] {ECO:0000313|EMBL:TDG51291.1, ECO:0000313|Proteomes:UP000295192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG51291.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TDG51291.1};
RX PubMed=30423125; DOI=.1093/jhered/esy059;
RA Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT the mojavensis Cluster.";
RL J. Hered. 110:118-123(2019).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR038051-1};
CC -!- SIMILARITY: Belongs to the flavin monoamine oxidase family.
CC {ECO:0000256|ARBA:ARBA00005995}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDG51291.1}.
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DR EMBL; LSRL02000010; TDG51291.1; -; Genomic_DNA.
DR RefSeq; XP_017956032.1; XM_018100543.1.
DR AlphaFoldDB; A0A484BU58; -.
DR STRING; 7232.A0A484BU58; -.
DR GeneID; 108651092; -.
DR KEGG; dnv:108651092; -.
DR OMA; SSRGEMF; -.
DR OrthoDB; 5402444at2759; -.
DR Proteomes; UP000295192; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0140682; F:FAD-dependent H3K4me/H3K4me3 demethylase activity; IEA:UniProt.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0010558; P:negative regulation of macromolecule biosynthetic process; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.90.660.10; -; 1.
DR Gene3D; 1.10.287.80; ATP synthase, gamma subunit, helix hairpin domain; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR017366; Hist_Lys-spec_deMease.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR007526; SWIRM.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR10742; FLAVIN MONOAMINE OXIDASE; 1.
DR PANTHER; PTHR10742:SF386; LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR Pfam; PF04433; SWIRM; 1.
DR PIRSF; PIRSF038051; Histone_Lys-demethylase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50934; SWIRM; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR038051-1};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR038051-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000295192}.
FT DOMAIN 164..263
FT /note="SWIRM"
FT /evidence="ECO:0000259|PROSITE:PS50934"
FT REGION 1..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 873..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..80
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..897
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 271..299
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR038051-1"
FT BINDING 300
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR038051-1"
FT BINDING 306
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR038051-1"
FT BINDING 322..323
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR038051-1"
FT BINDING 810
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR038051-1"
FT BINDING 819..820
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR038051-1"
SQ SEQUENCE 897 AA; 98640 MW; 1A29863E9CAA10F4 CRC64;
MKPTQSGGSG TSAAKMGEPI EYVTLISDDS DGEPSPKRNP SGSGSQAASH TKAKFDDDSN
DTPATSDERR TSRRNKPKVD YTNKPATASA ENTASDKCSS GSSGSSSGLT DKRSQGQAEQ
RTRKTEAGAN QSTGTGSRST LPKDTNGTNG EARDNSTPTV LSGQEGAVFQ SRLPFSKMTP
NEEACFPDIS CSGILGHRVF LNIRNSLLHM WVDNPKTQLT FDSALKRLPP PFDSDPNLVR
RVHSFLERHG FINFGIFKRL SPIPSKKLGK VIVIGAGISG LAVGQQLQQF GMDVIVLEAR
DRVGGRIATF RKNSYIADLG AMVVTGVYGN PMTILSKQIG MDLVPIQQTC PLYGPDGKPV
PKEKDDVIER EFNRLLESAS YLSHRLDFNY AGNNPVSLGD ALEWIINMQD KAVQEKRAAH
MHEIISAQTR IIEHRKRLKA TLQKIATLRS DLQNLIKQRQ PRSAHNENSY ASQEYAIRNT
QIKLEDAISS EAEQRIEGHK LEMKLQEIEQ NAPSQVYLSS RDRLILDWHF ANLEFANATR
LDNLSLKHWD QDDDFEFIGH HTTVRNGYSC VPVALTENID IRLNSAVKEI KYTSKGVEIV
AENLKTSNSL MTYKADLAVC TLTLGVLKVA VTQEEAHHAN TVKFDPPLPD WKQQAIRRLG
FGNLNKVVLC FDRIFWDPNA NLFGHVGSTT ASRGEMFLFW SISSSPVLLA LVAGMAANIV
ESVTDDIIIG RCMSVLKNIF GNTSVPQPKE TVVTRWRSDQ WARGSYSYVS VGSSGSDYDL
LAAPVIPPTS HEPHFSKDTE ELPRLFFAGE HTIRNYPATV HGAYLSGLRE AGRIADYYLG
YPEGTPPDIG YSVTEAANSV SVGNVVKLRD LSPHLSDSPV SKKSEENSNI ADSTDVQ
//
