ID A0A484BYI6_DRONA Unreviewed; 749 AA.
AC A0A484BYI6;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Flap endonuclease GEN {ECO:0008006|Google:ProtNLM};
GN ORFNames=AWZ03_000934 {ECO:0000313|EMBL:TDG52701.1};
OS Drosophila navojoa (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG52701.1, ECO:0000313|Proteomes:UP000295192};
RN [1] {ECO:0000313|EMBL:TDG52701.1, ECO:0000313|Proteomes:UP000295192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG52701.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TDG52701.1};
RX PubMed=30423125; DOI=.1093/jhered/esy059;
RA Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT the mojavensis Cluster.";
RL J. Hered. 110:118-123(2019).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDG52701.1}.
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DR EMBL; LSRL02000003; TDG52701.1; -; Genomic_DNA.
DR RefSeq; XP_017956165.1; XM_018100676.1.
DR AlphaFoldDB; A0A484BYI6; -.
DR STRING; 7232.A0A484BYI6; -.
DR GeneID; 108651190; -.
DR KEGG; dnv:108651190; -.
DR OMA; RNLYFRT; -.
DR OrthoDB; 26655at2759; -.
DR Proteomes; UP000295192; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004520; F:DNA endonuclease activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd09869; PIN_GEN1; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR041012; GEN_chromo.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11081:SF73; FLAP ENDONUCLEASE GEN HOMOLOG 1; 1.
DR Pfam; PF18704; Chromo_2; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000295192}.
FT DOMAIN 1..95
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 134..211
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 480..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 749 AA; 84646 MW; 44EF64113ADAE144 CRC64;
MGVKELWSIL TPYADRKPIC ELRGKKVAID LAGWVCESLN VVDYFVHPRH HLKNLFFRTC
YLIWEQVTPV FVLEGVAPKL KSQVIAKRNE LQFRGARPKD KDKDAAMPTQ AVAKNDKGRT
RFNHVLKQCE NLLLSMGIQC VQGPGEAEAY CAFLNKHGLV DGVISQDSDC FAYGAVRVYR
NFSVSTQGAQ AAAGGAVDIY DMQEICNHMD FGQNKVIVMA LLCGCDYCPD GIGGIGKDGV
LKLFNKYKES DILDKLRNWR SETDKYNALE LRVDDKSICS NCGHIGRTQS HTKSGCGVCR
THRGCDETLW KEQRLSIKAE LTLRKKALLD VDFPNEEIIS EFLTEPAKLP NLVLDWRQPN
IVKFIKQIGH LLQWPEIYCF QKFFPLLTRW QVQQPKEALA LVQPQEIIKK RTVKGIASLE
LRWEDTSGCF KGLIPHDQIE EFKLDHPKGM EELYYTVEPL DMLQATYPDM VAAFIKSKEK
PPKKTATRKK KVNSDPPLSA LENLSDLAAT TAEIITKPKR GKKKMTTNPT ANGQKTMQHF
LKQKENTPIK SSRQLANQCS TPLNKHLPSD LESDAEFDMS DIINGIVSNP QAVPAVTKHD
GYQLHYEPLA EDLSLRLAQL SLDKHDVSHQ QSLLIDDVDL LVQKRRDISM RTESMPSAKR
YSLDDSFDLL VKGDLKKVPH LVKTPVERFK QQHRLSTANK SKQLPSIKPT ANVSYFFNQS
VEGADAFEQL MESSLKDSEE DLVVISDSD
//
