ID A0A484D369_PERFV Unreviewed; 3598 AA.
AC A0A484D369;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN ORFNames=EPR50_G00089430 {ECO:0000313|EMBL:TDH09692.1};
OS Perca flavescens (American yellow perch) (Morone flavescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Percoidei; Percidae; Percinae; Perca.
OX NCBI_TaxID=8167 {ECO:0000313|EMBL:TDH09692.1, ECO:0000313|Proteomes:UP000295070};
RN [1] {ECO:0000313|EMBL:TDH09692.1, ECO:0000313|Proteomes:UP000295070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YP-PL-M2 {ECO:0000313|EMBL:TDH09692.1};
RC TISSUE=Blood {ECO:0000313|EMBL:TDH09692.1};
RA Feron R., Morvezen R., Bestin A., Haffray P., Klopp C., Zahm M., Cabau C.,
RA Roques C., Donnadieu C., Bouchez O., Christie M., Larson W., Guiguen Y.;
RT "A chromosome-scale genome assembly of the yellow perch, Perca
RT flavescens.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDH09692.1}.
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DR EMBL; SCKG01000008; TDH09692.1; -; Genomic_DNA.
DR STRING; 8167.A0A484D369; -.
DR OrthoDB; 2873210at2759; -.
DR Proteomes; UP000295070; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00037; CLECT; 1.
DR CDD; cd00063; FN3; 18.
DR CDD; cd14616; R-PTPc-Q; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 23.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF3; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 14.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00060; FN3; 27.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 16.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS50853; FN3; 21.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000295070};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..3598
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019786319"
FT TRANSMEM 3191..3210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 106..206
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 210..331
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 462..565
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 764..851
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 938..1026
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1111..1204
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1205..1299
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1447..1535
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1538..1637
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1707..1811
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1812..1907
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1912..2001
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2006..2095
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2100..2187
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2192..2293
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2298..2400
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2405..2493
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2497..2590
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2594..2685
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2686..2806
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2811..2905
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2910..3008
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3303..3558
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 3476..3549
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 381..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1629..1667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1715..1737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3598 AA; 394580 MW; 158C32F59FD46459 CRC64;
MGGTERLWLL ASLCQVVLLT CEQHLNPVEV EVVFQSFPSI KDADTYTVTC RTASNQLVYV
EPFKHSACSP DCKMSLRLVE DPGGYNITLR ASRNDATLEA KTFHFIPASP SSLHVYSTTT
TALLTWRLHR QQSLSTLSLY NTQTQSVTHI FNVNSSEANS WYTVKGLQPG TRFKAKVVVT
TFLKHLNMTL EQSLSSGMET AQCPPDWLAD GRSCYTVRRT GLTWSDAQHR CRGLAAGSHL
ADLKTLEDLL FISSHLRSHN NLLLLWTGLN DQQEEGKPLW SDGSVYNLTN TMMSLLPANQ
TDCFALQRNA TGPGYFLTPF FCNIPLPFIC HCQTPTAPAS LSFDLVQVTE QHVELHWSDL
SPLNSLNLSS FEIFLQYQEE TNGESGQGEE DSGRKSEDKK RTQSQSSITK IVRVPIFLSS
RGVTVAGLSP GSIYTFTLQA SHPAGFAWSL GQTRTAYTRP LPPQNITVGS VSVSQISVHW
MMMDAQFRVG WTFVVRYVDM SSRQERIVGM TNNSRLSETG GLQSYTAVIG GLESYREYRV
EVYTVTQHGI ESCGQAPVTV LTAVRAPRGL EVLSTTGNLT VCWTSSPDDP SDGYYITSHP
LINPTPTSLW INQSSPGAHW VNESVCVNLG TFTPGQTYEV GVVSLRGKDR SKRTSVIHTT
DPMPVQVAVS LSVGTNSAQL YIQQPQLGLI DGVKVCVCPG MCDSLCEGLC GNTCDWYSLP
AGVHIITISN LSPGSDHQLR VYSTSREKIG PPYYTHPVRT NQAPPIRVRE GVVTDSSIEL
LWDPAQGQAL SYEVICLNCD HSHMVQKVFS QSATFSSLTP CRFYHFAVRT EKESFTDSSP
VTINITAAPS PVKVSLVNKT TSSIHICWSM LGGVTSGLIL SIKNRTSSQE LIISPQEARS
YSFEGLAYGS QYTIEVISTC RERRSKPAAM ILHTLPEVPQ EVALSEQVVT SVFVTWRPPP
GQVEGYKLVF GLRSVDRKSW IEVLVRGARY EIRDLIPGSD YGVSIQSVLG SDTSQAVHRE
FSTRPAGLCG LHLDNMNSSS VSVSWDSAFG GFDFHKVTVA NTSVTNTLTV AKEERVAVVT
GLVAGCSYNV SAERVRGVTA GSAAFLTVTT VPVRVHGVRV VNVSARAFSL RWEQAAGCVD
HYQVNLLPNQ GKVTVHPAHD GYIQADVVNV SPRTQYSVTV TAASSSNISP GVSRMINTNE
SVPGPPLNLE GEAVGSNGIL LSWTMPRYTS NIDGYVIRYK EVCPYPDPTF TQVTKYLDVP
ETLLTEFTSG STYHIQVAAI APAGIGAFSK SLYIKTSESP PGLVTNLTAF AQNHTFVVVT
WFLPHRINGL ITKFAVKAKH ARTGQTVRIL EVNAEDIMTG ALPHCNDAAD ILSRATLSPL
GITASSSPIT LSAVPPAASW SVPISVGVDQ LRPYTAYLFE VSAFTSDGEG QIASTMVRMP
ESAPEDPPQN FFILNMTSRS ISVSWSSPRI ITGKFTYVLY LYGPTGYLFE NSTGDTRFAL
SGLTPYTRYT VAVRAKAAGE VGPAAEDVII TPAEAPSAVQ DLMAEAEDSV SIRVSWRMPA
QPNGPITQYK LQVLVAEILL QDITLTAEMN TTGLHKDKTL PPDVRNYPGR RKRTAELSLI
TSPPTFTAAI SDRTLPTGAT ASSLTHSGQR SADPITNTNA QSTAHSMVTE KSSTSYISAS
YSTSIQSSAV SGTSAFSLTS VPPATLPPWL TRQSHAGDMT SDSSPLALTP GQLRSSTHDA
SVTGHFLTRS ATATGTTGVT VREEVMNVLS EELSYLVSDL NPFTEYTFRV TASTTVGEGP
ATNITEKTRE QVPSSVLEVS YQNISSTSIL VSWIPPLNPN GRITHYTVYG LKLHSNQALK
WVTNATSILI TDLDKYTGYK LRVAASTAVG ESSLSEEDDI FVVTLEDEPD SPPVNLTVVD
TSPSTTTLAW SAPEQANGMI QRYEVLYENE SFSALMNTSS NTITLKNLKP FSNYTVSVRA
YTRYGHGNQT SDALYLLSGE DVPGSPPYGV TYESLSPSEV NVTWQPPLLP NGVITHYSLE
LWNSSHYLNL TSPTNNIHIT HLRKYARYRV MVQAHTRVGA GNYSSEPLNI TTLEDAPDTP
PQFLHAKKLS DYEVELSWQP PLEANSDILY YIVRVWNETT ELWQNVTGTS VVINVDSESR
YNASVSSWNR LGDGGVLIYI SFNTINAEPF DPPRNVTFTN VTTSSVNLLW HPPAEPNGII
VHYTIYYSYD NTVAEQRVPI SDLGAPASPD SALSYTLTRL IGGTNYTLWM TSSTAQGDGG
VQSEPLTLFL PEDVPSDSVQ NLTAQIFSST AIIVSWDPPM EPNGRPTYLL TLQEAGTPPD
VSNQGAPAVN KTISRNTTDN VFLFTRLKKY FPYVLTVTPA TGAGAAYNHT STMYLRTDDD
IPSSAPLLVS TRNLSSSSIV IVWQRPLEAN GEITEYTLTV FGPGGSSTSH TPSTSFTLTN
LLPYTAYNLT VTAATRKGSG PYLLLQLHTD EGGPMSPPRN LTIYNHTAVS VLLSWEPPLE
PNGVVIQYGF RIRDLITHTV THRNSSGPST TEYLSGFRPH SSYEISVYTY TRVGHGNQFS
SPVTFTTNES VADAVGNLSC SGVSWDSIQL FWELPANPNG QIIFYEILLK VDSQSYTHQA
HLPEYTVTGL SPDQEYTLTV AAVNSAGSGD SLNCTASTLS ESAPAAPRFL TISQVTPNNV
TLQWAPPLSI PGLLKEYHVI AQLLSTVCEP NTLTTAQPSP EDELTSDCVD SNVTVSVNAS
DGIEKNHSVT FQSLAKYRYY RFKVAAVTNA GVGEYTHWNY ARTLAGNPDD PPRDLKVTPT
SKGLHIAWDA PAVLSGPTSY LVQVDGPGLN ISTVRAPGEL TTVVVTNLTA FTRYLVTITA
FIGPLKHAAS QGKAIGPIEF QTLEEEPKDP PKNVVVSVMQ EEVNRVKVTF FPPEEPNGNI
TAYFVYVYEK EQLIKNISLN ITQRDQDMLT AVIEGLKGGH SYSIQISARN GAGRSPPSPH
VQITTGIKAP AKPTQRPQAV LGHGGVAMVT HRSITIHMPA CFYSDDNGPI TKIQVIVAES
GVKDMQNLTN WKNAFFDRPA PYLTDKGFPN PSCDLGDGAL PTDTRVRGGR SVSRGGGPLV
RKNHTTYVIG ENDDCVKENN TDNFCNGPLK PKTVYVFRFR ATNINGQYTD SEYSEHVRTA
VDGLLTRDEQ IILGVLLSFF LAVLLIIIIC GSVKIHQRKK EGGTYSPREA EIIETKCKLD
QLIAVADLEL KQEKLNRYSS FFFRRKEIYV IQLLSYRKSL KPVNKKSFLQ HVEDLCANDN
SKFQEEFAEL PKLLQDLATT DADLPWNKSK NRFPNIKPYN NNRVKLLSEP GSAGSDYINA
SFVSGYLCPN EFIATQGPLP GTVADFWRMI WETGTHTIAM LTQCYEKGRI RCHKYWPEDN
KPMSVFSDIL ISKVSEEVLP DWTVRTLKVE KHGHYILVRH FNYTSWPEHG VPESCSTLIK
FVKAVRAHRH DNTTIVVHCS AGVGRTGVFI ALDHLIQHIR DHDFVDIYGL VAELRSERMC
MVQNLAQYIF LHQSTLELLN NKGNSQSIWF VSYSALEKMD SLEAMEGDVE LEWEETTM
//
