ID A0A484DE21_PERFV Unreviewed; 1121 AA.
AC A0A484DE21;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Solute carrier family 12 member 5a {ECO:0008006|Google:ProtNLM};
GN ORFNames=EPR50_G00036460 {ECO:0000313|EMBL:TDH13776.1};
OS Perca flavescens (American yellow perch) (Morone flavescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Percoidei; Percidae; Percinae; Perca.
OX NCBI_TaxID=8167 {ECO:0000313|EMBL:TDH13776.1, ECO:0000313|Proteomes:UP000295070};
RN [1] {ECO:0000313|EMBL:TDH13776.1, ECO:0000313|Proteomes:UP000295070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YP-PL-M2 {ECO:0000313|EMBL:TDH13776.1};
RC TISSUE=Blood {ECO:0000313|EMBL:TDH13776.1};
RA Feron R., Morvezen R., Bestin A., Haffray P., Klopp C., Zahm M., Cabau C.,
RA Roques C., Donnadieu C., Bouchez O., Christie M., Larson W., Guiguen Y.;
RT "A chromosome-scale genome assembly of the yellow perch, Perca
RT flavescens.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDH13776.1}.
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DR EMBL; SCKG01000004; TDH13776.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A484DE21; -.
DR STRING; 8167.A0A484DE21; -.
DR Proteomes; UP000295070; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF54; SOLUTE CARRIER FAMILY 12 MEMBER 5; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000295070};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 566..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 108..282
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 389..681
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 695..813
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 826..951
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 1053..1121
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 929..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..980
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1121 AA; 123047 MW; D95327A76D4B1462 CRC64;
MLNNLTDTEE GDGGAQSQGD SNPKENSPFI NSSDAAEEKT QQYDGKNMAL FEEEMDTSPM
VASLLSSLAN YSNLPQGSKE HEEAENNEAE SSRKKPVKAP ALGTLIGVYL PCIQNIFGVI
LFLRMTWLVG IGGVIGTFFI VFMCCTTTML TAISMSAIAT NGVVPAGGSY YMISRSLGPE
FGGAVGICFY LGTTFAGAMY ILGAIELLLI YIAPKAAIFP LEGLEGAEAE AALLNNMRVY
GTILLTSMAT VVFVGVKYVN KLALVFLACV ILSILAVYAG VIKTGIDAPE FPVCILGNRT
LVWKSFDVCA KTVETANGTV TTQLWRIFCD SPFLNATCDK YFTANNVTQI QGIPGVTSGI
LADNLFGTYY EKGDLIAKKF TESAEDQDDP LTNANRYVLA DITSFFTLLV GIYFPSVTGI
MAGSNRSGDL RDAQKSIPVG TIAAICTTSF VYMSSVVLFG ACIEGVVLRD KFGEGVHGNL
VIGTLAWPSP WVIVIGSFFS TCGAGLQSLT GAPRLMQAIA KDGIVPALRI FGQGKANGEP
TWSLLLTACI CEIGILIASL DAVAPILSMF FLMCYMFVNL ACALQTLLRT PNWRPRFKFY
HWALSFLGMS LCLTLMFLCS WYYAIVAMVI AGSIYKYIEF AGAEKEWGDG IRGLSLSAAR
YALMRLEEGP PHTKNWRPQL LTLVSTDAEQ NVEQPRLLSL TNQLKAGKGL TIVGTALEGT
YLENSEQSQR AEKALRKLME TEKVKGFCQV TVSSNLRDAT SHLLQASGLG GLKHNAVLVS
WPRNWRQGDE HQTWRNFVEL VRETTAAHLA LLVPKNISAF PSNGERFTEG HIDVWWIVHD
GGMLMLLPFL LRQHKVWRKC KIRIFTVAQL DDNSIQMKKD LTTFLYHLRI DAMVEVVEMH
DSDISAYTYE KTLVMEQRSQ MLKQINLSKN EREREIQSIT DSSRGSIRRK NPAAVTTQLS
VTEDPPAASK EEKPEEEVQL IHDNTTPTSP ATPATPLTPA EEAKSPGEQI QLTWTEKCDG
EPAKPPGAAT PEGIKDIFNM KPEWENLNQS NVRRMHTALR LNEVIIKKSS EAKLVLLNMP
GPPKNRTGDE NYMEFLEVLT DGLNRVLLVR GGGREVITIY S
//
