ID A0A484FH82_COLOR Unreviewed; 1205 AA.
AC A0A484FH82;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN Name=msh6 {ECO:0000313|EMBL:TDZ17383.1};
GN ORFNames=Cob_v009692 {ECO:0000313|EMBL:TDZ17383.1};
OS Colletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS
OS 414 / MAFF 240422) (Cucumber anthracnose fungus) (Colletotrichum
OS lagenarium).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum orbiculare species complex.
OX NCBI_TaxID=1213857 {ECO:0000313|EMBL:TDZ17383.1, ECO:0000313|Proteomes:UP000014480};
RN [1] {ECO:0000313|Proteomes:UP000014480}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422
RC {ECO:0000313|Proteomes:UP000014480};
RX PubMed=23252678; DOI=10.1111/nph.12085;
RA Gan P., Ikeda K., Irieda H., Narusaka M., O'Connell R.J., Narusaka Y.,
RA Takano Y., Kubo Y., Shirasu K.;
RT "Comparative genomic and transcriptomic analyses reveal the hemibiotrophic
RT stage shift of Colletotrichum fungi.";
RL New Phytol. 197:1236-1249(2013).
RN [2] {ECO:0000313|Proteomes:UP000014480}
RP GENOME REANNOTATION.
RC STRAIN=104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422
RC {ECO:0000313|Proteomes:UP000014480};
RX PubMed=30893003; DOI=10.1094/MPMI-12-18-0352-A;
RA Gan P., Tsushima A., Narusaka M., Narusaka Y., Takano Y., Kubo Y.,
RA Shirasu K.;
RT "Genome sequence resources for four phytopathogenic fungi from the
RT Colletotrichum orbiculare species complex.";
RL Mol. Plant Microbe Interact. 32:1088-1090(2019).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDZ17383.1}.
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DR EMBL; AMCV02000029; TDZ17383.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A484FH82; -.
DR STRING; 1213857.A0A484FH82; -.
DR Proteomes; UP000014480; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000014480}.
FT DOMAIN 1043..1059
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..186
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1205 AA; 134361 MW; 04D0D366FA4DEAC2 CRC64;
MKEKSSPAAR TPAKTPASLK RQPSSSAGTQ KTIVQFFSKT NNTASRSASK PALAQPAPDS
SPCLRESTRT NSLPRSNHQP SITPVPSSEA VGPPSSQENL DTAGLKVSRT IPSVTSSSPT
RKTRKPVNYA EATDEEDDDP FVRIRAVSSR HRTKIPATLA DDGDDYEDGE SVQAADSDDD
MLEFVVSDDS DTPSHQKKRK RREATKSTQP RKKANVSSPP GKIDINEEDE AMEGFPSTST
AQQWRYDPNS STPGDSRPLK SSVVRRAKAV TGKEKPHTTQ PEDRYPWLAN IQDLGNNSPG
HPDYDPSSVY IPPRAWKDFS PFEKQYWEIK QKLWDTVVFF KKGKFYELYE NDATIGHQLF
DLKLTDRVNM RMVGVPESSL DMWVNQFVAK GYKVARVDQM ESALGKEMRE RGDSSAKSKK
ADKIIRRELA CILTGGTLVD GGMLQDDLAT YCASLKESVI DGKPAFGIAF VDCATGQFLI
TEFEDDADLT KFETFVAQTS PRELIVEKGR MSTKAVRILK NNTSPMTIWN NLKPGTEFWD
ADTSRREIES GRYFAKEDRH AEVWPEILAQ AKGKPMLMSA LGALIHYLKK LKLDGNLLSQ
GNFEWYTPIR RNGTLILDGQ TLINLEIFSN TVNGGPEGTL FTLLNRCVTP FGKRLFRQWV
CHPLCDIVRI NERLDAVGML NSDRSVREQF SSQMTKMPDL ERLISRIHAE SCKPEDFVRV
LDGFEQIEYT IGLLGAFGGG NGLVERLLSS MPKLDEPLSY WKTAFNRKKA REEKMLIPER
GIEEDFDNSQ DRIGEIRHEL QALLAKKKSE LKCKTVKFTD VGKEIYQVEV PKAVKVPSNW
RQMSATSSVK RYYFDQLTGL VRELQEAEET HSQIAKEVAV RFFRRFDADY ETWAQSIRIV
AQLDCLVSLA KASSSLGEPS CRPEFIDQDR SVVEFDELRH PCMLNTVADF IPNDVNLGGG
SAKINLLTGA NAAGKSTVLR MSCIAVIMAQ IGCHVPALSA RLTPVDRIMS RLGANDNIFA
SQSTFFVELS ETKKILAEAT PRSLVILDEL GRGTSSYDGV AVAQAVLHHV ATHVGCIGFF
ATHYHSLATE FENHPEIRPR RMQIHVDEEQ RRVTFLYKLV DGIAEGSFGM HCAAMCGISN
RVIERAEVAA KEWEHTSRLK ESLDKARSGC YIPLGILSDV ASLLNGGGEV RNRGVEVLLR
AVEAL
//
