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Database: UniProt
Entry: A0A484GIQ6_SOUCH
LinkDB: A0A484GIQ6_SOUCH
Original site: A0A484GIQ6_SOUCH 
ID   A0A484GIQ6_SOUCH        Unreviewed;       427 AA.
AC   A0A484GIQ6;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   22-FEB-2023, entry version 12.
DE   RecName: Full=Gap junction protein {ECO:0000256|RuleBase:RU000630};
GN   ORFNames=DBR06_SOUSAS21310039 {ECO:0000313|EMBL:TEA35409.1};
OS   Sousa chinensis (Indo-pacific humpbacked dolphin) (Steno chinensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Delphinidae; Sousa.
OX   NCBI_TaxID=103600 {ECO:0000313|EMBL:TEA35409.1, ECO:0000313|Proteomes:UP000295264};
RN   [1] {ECO:0000313|EMBL:TEA35409.1, ECO:0000313|Proteomes:UP000295264}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MY-2018 {ECO:0000313|EMBL:TEA35409.1};
RC   TISSUE=Skin {ECO:0000313|EMBL:TEA35409.1};
RX   PubMed=30031902;
RA   Ming Y., Jian J., Yu F., Yu X., Wang J., Liu W.;
RT   "Molecular footprints of inshore aquatic adaptation in Indo-Pacific
RT   humpback dolphin (Sousa chinensis).";
RL   Genomics 0:0-0(2018).
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell.
CC       {ECO:0000256|RuleBase:RU000630}.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC       {ECO:0000256|RuleBase:RU000630}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, gap junction
CC       {ECO:0000256|ARBA:ARBA00004610}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004651,
CC       ECO:0000256|RuleBase:RU000630}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the connexin family.
CC       {ECO:0000256|RuleBase:RU000630}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TEA35409.1}.
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DR   EMBL; QWLN02007483; TEA35409.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A484GIQ6; -.
DR   Proteomes; UP000295264; Unassembled WGS sequence.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0007154; P:cell communication; IEA:InterPro.
DR   Gene3D; 1.20.1440.80; Gap junction channel protein cysteine-rich domain; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; CONNEXIN; 1.
DR   PANTHER; PTHR11984:SF52; GAP JUNCTION GAMMA-2 PROTEIN; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Gap junction {ECO:0000256|ARBA:ARBA00022868,
KW   ECO:0000256|RuleBase:RU000630};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000295264};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000630};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        80..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        208..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        262..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          45..78
FT                   /note="Connexin N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00037"
FT   DOMAIN          219..285
FT                   /note="Gap junction protein cysteine-rich"
FT                   /evidence="ECO:0000259|SMART:SM01089"
FT   REGION          106..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          295..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          358..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..137
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..168
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        411..427
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   427 AA;  45797 MW;  6E3B4CF47B6D6DD2 CRC64;
     MTNMSWSFLT RLLEEIHNHS TFVGKVWLTV LVVFRIVLTA VGGESIYSDE QTKFTCNTRQ
     PGCDNVCYDA FAPLSHVRFW VFQIVVISTP SVMYLGYAVH RLARASQDER RRASRRRQGR
     LAPRAPLPPP PHPGWPEPTD LGEEEPMLGL GEEDEDPGAA EGLGEDDEAE DVGAAKGAGG
     DTKATGVPGP AGQHDGRRRI QREGLMRVYV AQLVARAAFE VAFLVGQYLL YGFEVRPFFA
     CSRQPCPHVV DCFVSRPTEK TVFLLVMYVV SCLCLVLNLC EMAHLGLGSA QDAVRSRHPL
     PTTPGPMPRQ QPCGLPAAPS GLACPPDYSL VVRAAERART HDQDLANLAL QALQDRRSLG
     DLDSPPGPGL PATARGPPRA GAPASGSGSA TSGGTAGGQG RPGAKPRMGS EKGSASSSRE
     GKTTVWI
//
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