ID A0A493SVE8_ANAPP Unreviewed; 452 AA.
AC A0A493SVE8;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Phosphatidylcholine:ceramide cholinephosphotransferase 1 {ECO:0000256|ARBA:ARBA00039805};
DE EC=2.7.8.27 {ECO:0000256|ARBA:ARBA00038996};
DE AltName: Full=Sphingomyelin synthase 1 {ECO:0000256|ARBA:ARBA00042067};
GN Name=SGMS1 {ECO:0000313|Ensembl:ENSAPLP00000017579.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000017579.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000017579.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000017579.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC {ECO:0000256|ARBA:ARBA00005441}.
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DR STRING; 8840.ENSAPLP00000019816; -.
DR Ensembl; ENSAPLT00000018715.1; ENSAPLP00000019816.1; ENSAPLG00000002477.2.
DR Ensembl; ENSAPLT00000021463.1; ENSAPLP00000019829.1; ENSAPLG00000002477.2.
DR Ensembl; ENSAPLT00000032790.1; ENSAPLP00000024504.1; ENSAPLG00000002477.2.
DR Ensembl; ENSAPLT00000040702.1; ENSAPLP00000017579.1; ENSAPLG00000002477.2.
DR Ensembl; ENSAPLT00000046253.1; ENSAPLP00000025703.1; ENSAPLG00000002477.2.
DR GeneTree; ENSGT00940000158306; -.
DR Proteomes; UP000016666; Chromosome 6.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000138; C:Golgi trans cisterna; IEA:Ensembl.
DR GO; GO:0047493; F:ceramide cholinephosphotransferase activity; IEA:Ensembl.
DR GO; GO:0002950; F:ceramide phosphoethanolamine synthase activity; IEA:Ensembl.
DR GO; GO:0033188; F:sphingomyelin synthase activity; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0046513; P:ceramide biosynthetic process; IEA:Ensembl.
DR GO; GO:0006686; P:sphingomyelin biosynthetic process; IEA:Ensembl.
DR CDD; cd01610; PAP2_like; 1.
DR CDD; cd09514; SAM_SGMS1; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041418; SAM_3.
DR InterPro; IPR045221; Sphingomyelin_synth-like.
DR InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR PANTHER; PTHR21290:SF28; PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 1; 1.
DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR Pfam; PF14360; PAP2_C; 1.
DR Pfam; PF18016; SAM_3; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 135..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..70
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
SQ SEQUENCE 452 AA; 52286 MW; 3751D82AE2735F5B CRC64;
MKEVLLWSPE EVTNWLTENA VPEYCEPLKS FTGQDLINLT EEDFKKTPLS RVSSDSGQRL
LHMIETLKMA HHIEAHKNGH INGHIPVSMR NTTHENGFSS KMKLNGVPNG YKKEMIKIPM
PEPERSQYPM EWGKTFLAFI YALFCFIFTT VTISVVHERV PPKEVQPPLP DAFFDRFDRV
QWAFSICEIN GMILVGLWFV QWLLLKYKSI ISRRFFCIVG TLYLYRCITM YVTTLPVPGM
HFKCSPKLFG DWESHLRRIM KLIAGGGLSI TGSHNMCGDY LYSGHTVILT LTYLFIKEYS
PRRLWWYHWL CWTLSMVGMF CILLAHDHYT VDVVVAYYIT TRLFWWYHTM ANQQVSFSQS
LDPHGPACCS MAVGEYPRFA LSLSAEVGMD KHPSLVKHPT LPPSLWACRK EEVSLVGFVL
CLDCKKYLKV CLQAGKQAYL LWLCNLIFLK SL
//
