ID A0A493SWL9_ANAPP Unreviewed; 2173 AA.
AC A0A493SWL9;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Dedicator of cytokinesis 10 {ECO:0000313|Ensembl:ENSAPLP00000017977.1};
GN Name=DOCK10 {ECO:0000313|Ensembl:ENSAPLP00000017977.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000017977.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000017977.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000017977.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR Ensembl; ENSAPLT00000027098.1; ENSAPLP00000017977.1; ENSAPLG00000006337.2.
DR GeneTree; ENSGT00940000157469; -.
DR Proteomes; UP000016666; Chromosome 9.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd11699; DHR2_DOCK10; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF71; DEDICATOR OF CYTOKINESIS PROTEIN 10; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 2.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT DOMAIN 198..307
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 689..731
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 732..836
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1676..2136
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 173..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2140..2173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2147..2173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2173 AA; 248487 MW; 8924A25AC78F2D1A CRC64;
MGCAASIVLL QAFRSVVQRN CPHICRRRRR EELSHEILPL DSDDEMSRPR TLIIMQEKPK
LLEPLDYEAV ITEIEKNIGD SLFKDLILFP DDDFSTDTIS LEIRTLYPSV PEDAEQKAES
LFVKEACKYY NSHWHVVNYK YEQYSEDFRH LPQNECRPEK LPSHSFEIDH EDVDKDEDTT
SHSSSKGGGG GGGGLAAGVF KSGWLYKGNF NSTVNNSITV RSFKKRYFQL TQLSDNSYIM
NFYKDEKISK EPKGCIFLDS CTGVVQNNRL RKHAFELKMN DLTYFVLAAE NEQDMDDWIF
TLNKILQINP EGTIQERKSA DLTDLKLDPA DASVNDDCSQ EETDSSENAL HPDFAKYITE
TEETVKASRN TERLNLFSLD PDIALLNPQK KEFPGTNSSI KPFEEKPAKR ILITCKSLSL
NLQACVTENE NDPATNVEPF FVSVALYDIR DGRKISADFH VDMNHTLVRQ MISGYSFSLE
NGTVENIDSN EIEEPKVKGF PEEWLKYPKQ ALFSISNPHS EIVLVAKIEK VLTGNIASSA
EPYIKNPDSF KCAQKVLKSN KQFCSKLGKY RMPFAWSVRP VFRDNQGNVD RDSRFSPLFR
QESNKISMED LIKLIAEYRR AEKISKIQTI PGSLEIAVDC VPLEHPNCVT SSFIPIKPFN
DIKEHQPTVE VEEFVQESTK YSRPYRVYKN QIYIYPKHLK YDSQKYFSKA RNITVCIEFK
SSDEEGAKPL KVKIELPTQL HKKHHILFSF YHVTCDINAK ANAKKKEALE TPVGYAWLPL
LKDAQLASQE HNVPVASSLP PNYLSLQEPT SGKQIGCDVK WVDSGKPLFK VSTFVVSTVN
TQDPYLNNFF HQCQEREKDF SQPPTSNFIN SCKNLLRIEK IHVIMNFLPI VLNQLFWVLV
QNSDDEVATA VTRVLTNIVA KCHEEQLDNC INSYVTYVFR TKSFEERTVH EELAKNMTGL
LKLNDQVTVK QVLKHSWFFF AVILKSMAQH LVDTNKIKVS RTQRFPESFQ TELDTLVMVL
ADHVVWKHKD ALEETRNANY STAKFLKRCF TFMDRGFVFK MVNNYISMFG TGDSKTLHQF
KFDFLQEVCH HEHFIPLCLP IRSSNIPDPV TPSESTQDYR TSDIPEYTLT NEFCRKHFLI
GVLLREVGFA LQEDQDIRHL ALAVLKNLMA KHSFDDRYAE PAKQAQIANL YMPLYGMLLD
NMPRIYMKDM FLFNINTSNQ GSRDDLSTAG GFQSQTAMKH ANSVDTSFSK DVLNSIAAFS
SIAISAANHA DSRASLASLE SNPSTNEKNS ERTDTCEKIM RPLSLIGSTL RFDKLDQAET
RSLLMCFLHI MKTISEDALI SYWLRAPFSE ITDFFSILEV CLQNFRYLGK RNIVRKIAAA
FKFVQATQNN GTLKGSNSSG QTSGLLSQWM HSTSSHDGHK HHRSQTLPII RGKNALSNPK
LLQMIDSSTA SSSNETDIVQ FVDTEANIAT EVSLTILDLL CLYTLNHQRQ LQQSDCQNAL
MKKVFDTHML FLQINQSAAA LKHVFAALRL FVGKFPSAFF QGQADLCGSL CYEILKCCNH
RSRSTQTEAS ALLYFFMRKN FEFNKQKSIV RSHLQLIKAV SQLIADAGIG GSRFQHSLAI
INNFANGDKQ MKNVNFPAEV KDLTKRIRTV LMATAQMKEH EKDPEMLVDL QYSLANSYAS
TPELRRTWLE SMAKIHARNG DLSEAAMCYI HIAALIAEYL KRKGYWKMEK ICTSRMLLED
GQVCDSNVLL TTHTGGSLFS MGWPAFLSIT PNIKEEGAMK EDSGMQDTPY NENILVEQLE
LCVEYLWKSE RYELIAEVNK PIIAVFEKQR DFKRLSDLYY DIHRSYLKVA EVVNSEKRLF
GRYYRVAFYG QGFFEEEEGK EYIYKEPKLT GLSEISQRLL KLYADKFGID NVKIIQDSNK
VNPKDLDPKY AYIQVTYVTP FFDEKEAEDR KTDFEMHHNI NRFVFETPFT LSGKKHGGVE
EQCKRRTILT TSHLFPYVKK RIQVISQTST ELNPIEVAID EMSKKVSELN QLCTMEEVDM
IRLQLKLQGS VSVKVNAGPM AYARAFLEET NAKRYPDNQV KLLKEIFRQF ADACGHALDV
NERLIKEDQF EYQGEMKSHY KDMLSELSAV MNEQIAYKED SAKQQGMERT YSRVINRTSS
SAPAATTPSN PDA
//
