ID A0A493SXC4_ANAPP Unreviewed; 888 AA.
AC A0A493SXC4;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Transmembrane protein 63B {ECO:0000313|Ensembl:ENSAPLP00000018274.1};
GN Name=TMEM63B {ECO:0000313|Ensembl:ENSAPLP00000018274.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000018274.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000018274.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000018274.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A493SXC4; -.
DR STRING; 8840.ENSAPLP00000018274; -.
DR Ensembl; ENSAPLT00000037463.1; ENSAPLP00000018274.1; ENSAPLG00000016007.2.
DR GeneTree; ENSGT00940000157084; -.
DR Proteomes; UP000016666; Chromosome 3.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:Ensembl.
DR GO; GO:0008381; F:mechanosensitive monoatomic ion channel activity; IEA:Ensembl.
DR GO; GO:1990760; F:osmolarity-sensing monoatomic cation channel activity; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF38; CSC1-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 108..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 583..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 708..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 744..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 776..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 184..289
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 305..487
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 498..770
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..45
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 888 AA; 100629 MW; B5997FBD884B9532 CRC64;
MRAAAPSALP WPSGAEDCRE EPRPPPPLPA PPVPVPVPVA GGSPEPSAPG PGEDDEAVEM
LPYVIATLGS AGGTCKAASC SNSTKDYCYS ARIRSTVLQG LPFGGVPTVL ALDFMCFLAL
LFVFSILRKV AWDYGRLALV TDADRRRRWQ TEREEREYVA SALHSDNHDR YERLTSVSSS
VDFDQRDNGF CSWLTAIFRI KDDEIRDKCG GDAVHYLSFQ RHIIGLLVAV GVLSVGIVLP
VNFSGDLLEN NAYSFGRTTI ANLNSGNNLL WLHTSFAFLY LLLTVYSMRR HTSKMRYKED
DLVKRTLFIN GISKYAEPEK IKKHFEEAYA NCTVLEARPC YDVARLMFLD AERKKAERGR
IYFTNLQGKE NTPSMINPKP CGHLCCCVIR GCEEVEAIEY YTKLEEKLKD DYKREKEKVN
EKPLGMAFVT FHNETITAII LKDFNACKCQ GCACRGEPKA SSCSESLHVS NWTVSYAPDP
QNIYWEHLSI RGFIWWIRCL VINVVLFILL FFLTTPAIII TTMDKFNVTK PVEYLNNPII
TQFFPTLLLW CFSALLPTIV YYSAFFEAHW TRSGENRTTM HKCYTFLIFM VLLLPSLGLS
SLDVFFRWLF DKKFLAEATV RFECVFLPDN GAFFVNYVIA SAFIGNAMDL LRIPGLLMYM
IRLCLARSAA ERRNVKRHQA YEFQFGAAYA WMMCVFTVVM TYSITCPIIV PFGLMYMLLK
HLVDRYNLYY AYLPAKLDKK IHSGAVNQVV AAPILCLFWL LFFSTVRTGF LAPTSMFTFV
VLVITIVICL CHVCFGHFKY LSAHNYKIEH TEVDTIESRQ NGRPATNLPA PKSTKYIAQV
LQDSSPEGEA TESEEQGSQD EELITADGMN DTDFQSCEDS LIENEIRQ
//
