ID A0A493SZE9_ANAPP Unreviewed; 779 AA.
AC A0A493SZE9;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Rho GTPase activating protein 10 {ECO:0000313|Ensembl:ENSAPLP00000018972.1};
GN Name=ARHGAP10 {ECO:0000313|Ensembl:ENSAPLP00000018972.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000018972.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000018972.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000018972.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A493SZE9; -.
DR STRING; 8840.ENSAPLP00000018972; -.
DR Ensembl; ENSAPLT00000017628.1; ENSAPLP00000018972.1; ENSAPLG00000014077.2.
DR GeneTree; ENSGT00940000159559; -.
DR OMA; MRSPMVQ; -.
DR Proteomes; UP000016666; Chromosome 4.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR CDD; cd04374; RhoGAP_Graf; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF5; RHO GTPASE-ACTIVATING PROTEIN 10; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 265..372
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 388..573
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 721..779
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 583..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 779 AA; 89083 MW; A2F72DE1CE1E02DE CRC64;
MGLQPLEFSD CYLDSPWFRE RVRAHEAELE KTNKFIKELL KDGKNLIAAT KNLSAAQRKF
AHSLRDFKFE FIGDAETDDE RCIDASLHEF SNFLKNLEEQ REILALSVTE TLIKPLERFR
KEQLGAVKEE KKKFDKETEK NYSLLEKHLN LSAKKKELQL QEADSQVEQN RKHFYELSLE
YVCKLQEIQE RKKFECVEPV LSFFQGLFTF YHQGYELAKD FSHYKMALQI NIQNTRNRFE
GTRSEVEELM NKIRRNPQEH KRANHFTMEG YLYVQEKRPA PFGSSWVKHY CTYRKETKKF
TMIPFEHRSG GKAGDEELFI LTYCTKRNID TIDRRFCFDL EASDRPGVPV TMQAFSEEDR
KLWMEALDGK EALFINLNKA SAKREGSAQL DKIGFTVIKK CINAVETRGI NDQGLYRVVG
VSSKVQRLLT LLMDAKTCNE VDLENSVDWE VKTITSAMKQ YLRSLPEPLM TYELHGEFII
PAKSGSPESR VNAVHFLVHK LPEKNKEMLD ILVKHLANVS KHAKRNLMTV ANLGVVFGPT
LMRPQEETVA AIMDLKFQNI VVEILIENHE KIFKTLPDAT FPEPISMPVS PPNAPPRQSR
RQGQRIKRPL AVYNLCLELD DADTHSSPKE DTPTGSMDSL SSQSPTPAFS SSPPGLLDRN
HLIMDSGDLT DWATNLSGQS RPSMVSWMNT PSTNPAATNT TPSAFSFPNP ATGSDRAVES
VAHRKARAVY PCEAEHSSEL SFQIGAIFED VQFSREPGWL EGTLNGKRGL IPQNYVQFL
//
