ID A0A493T3W1_ANAPP Unreviewed; 2226 AA.
AC A0A493T3W1;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Bromodomain adjacent to zinc finger domain 2B {ECO:0000313|Ensembl:ENSAPLP00000020350.1};
GN Name=BAZ2B {ECO:0000313|Ensembl:ENSAPLP00000020350.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000020350.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000020350.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000020350.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WAL family. {ECO:0000256|ARBA:ARBA00007444}.
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DR STRING; 8840.ENSAPLP00000020350; -.
DR Ensembl; ENSAPLT00000027136.1; ENSAPLP00000020350.1; ENSAPLG00000015688.2.
DR GeneTree; ENSGT00940000155359; -.
DR Proteomes; UP000016666; Chromosome 7.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05503; Bromo_BAZ2A_B_like; 1.
DR CDD; cd01397; HAT_MBD; 1.
DR CDD; cd15630; PHD_BAZ2B; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037374; BAZ2A/B_Bromo.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915:SF1; BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF15613; WSD; 2.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 746..817
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 1103..1168
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 1989..2039
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2135..2205
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 848..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1037..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1279..1359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1526..1547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1598..1629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1868..1889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2051..2100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..291
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..667
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..877
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1299..1314
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1315..1336
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2052..2100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2226 AA; 246186 MW; 62B5283935707625 CRC64;
MESGERLTSS SISSSAATSS PVSSTPSVPS AVSKGGLTTG AASLSSTINT CGYMFRTAGE
QPCNLSTVSS AFPVVSHPVF GLHAASSGYS EFGGLGILGT PTALAAHPQL APFPEWWRTA
DTHSRSGAAF FPPLLGIPPL FAPPAQNHDS TPFHSRATGK NSRGSTEKGI NGSLNGNSTT
AVCGVSTSVL STSIAVSAGQ VKTTTSGAGG RKYNQEQSKA QLLDTRADKI KDKKPRKKAV
ESSSNSDSDS GSSSDTSSEG ISSSDSDDLE EDEEEEEEDQ SAEESEDDES DSENEAHHKT
KNKVLMHSGV TDMKTDGQKT LEKSQEKRTH QQIPLVSDSQ THSSFPSQQK QPQVLSQQLP
FIFQSSQAKE ESVNKHTSVI QSTGLVPNVK PLSLVHQAKK ETYLKLIVPS SDLLKAGNKN
TSEDSIPLTS DIRSKREQYK QTFPAAHLKK QESSKNLKKV IAALSSSKST SSSPAHQKLT
SLENNHSNPF LTNALLGNHQ PNGVIQSVIQ EAPLALTTKP KSQTKINESV AISSSTPFSL
PVNLSACGKK TAGNRTPVMP STSPVLPGSG KDKAVSNNAV NAVKTQHRLH SPKLVVEQFR
GVDSDAPSSK DSDDSNDDDD DDEDEDEDDE DDDSDDSQSE SDSNSESDTE GSEDEDDEDD
KDQDESDTDT EGEKTPLKLN KTASSMKSSS IGPAAHSTPL NLQAAKAPGS APAALCPESQ
PAVFLGTAPS TLTPSTHCGI SKRRRVTDER ELRVPLEYGW QRETRIRNFG GRLQGEVAYF
APCGKKLRQY PEVVKYLSRN GIMDISRDNF SFSAKIGVGD FYEARDGPQG VQWCLLKEEE
VIPRIRAMEG RRGRPPNLDR QHSREESRMR RRKGRPPNVG STEFLDNTDA KLLRKLQAQE
IARQAAQIKL LRKLQKQEQA RAAKEAKKQQ AIMAAEEKRK QKEQIKIMKQ QEKIKRIQQI
RMEKELRAQQ ILEAKKKKKE EAANAKLLEA EKRIKEKEMR RQQAVLLKHQ ELERHRLDME
RERRRQHMML MKAMEARKKA EEKERLKQEK RDEKRLNKER KLEQRRLELE MAKELKKPNE
DMCLADQKPL PELPRIPGLV LAGSTFSDCL MVVQFLRNFG KVLGFDVNTE VPSLSILQEG
LLNIGDSMGE VQDLLVKLVS AAVCDPGLVT GYKAKTILGE HLLNVGINRD NVSEILQIFM
EAHCGQTELT ESLKTKAFQA HTPAQKAAVL AFLVNELACS KSVVSEIDKN IDYMSNLRRD
KWMVEGKLRK LRIIHAKKTG KRDTTGGGDI GEEQQSLETP TPGRKRRRKG GDSDYDDDDD
DDSDDQADED EEDEEDKEDK KGKKAEVCED EDDGDQTASV EELEKQIEKL TKQQSQYRKK
LFEASHCLRS MMFGQDRYRR RYWILPQCGG IFVEGMESGE GLEEIAKEKE KLKKVESIHI
KEEVFETSEE KLHCLNTTHC ERKEDLKEKD NTNLFLQKPG SFSKLSKLLE VAKMPPESDI
ISPKPTGSAA NGCTLSYQST SQNSLCSLQP SVSQSGNEKS DSNNLFSPIP SGTGKFYNSP
LIQSDQLLKT LTEKSRQWFS LLPRIPCDDI SVTHIDTPAT TTSLTPQSHP SSKSPSPVPS
PLLGSTSAQS PAGLSPFALP PLQQMKSGLP IMGLQFCGWS TGVLTSNVPF SSPLPAIGSG
LGLSEGNGNP FLTSSVPTSK SESPALQTEK VASASCTAVD VAKPVDYPNP KPIPEEMQYG
WWRITDPEEL KSLHKVLHLR GIREKALQKQ IQKHMDYITM ACMKNKDVAI IDINENEDNQ
VTRDVVENWS VEEQAMEMDL AILQQVEDLE RRVASASLQV KGWLCPEPAS EREDLVYHEH
KSITRLHKKH DGDCAGGGEG STSSLERKSD NPLDIAVTRL ADLERNIERR YLKSPLSTTI
QIKLDNVGTV TVPAPAPSIS GDGDGAEEDI APGLRVWRRA LSEARSAAQV ALCIQQLQKS
IAWEKSIMKV YCQICRKGDN EELLLLCDGC DKGCHTYCHR PKITTIPDGD WFCPACIAKA
SGQTLKIKKL QMKGKKSNEQ KKSRKLSLAG DTEDEDSATT STSLKRGKTD AKKRKMDENV
SVSQLKQENF TAIKKPKRDD SKDLAICSMI LSELETHEDA WPFLLPVNLK LVPGYKKVIK
KPMDFSTIRD KLTSGQYPNL EAFSLDVRLV FDNCETFNED DSDIGRAGHN MRKYFEKKWT
EIFKLS
//
