ID A0A493T445_ANAPP Unreviewed; 350 AA.
AC A0A493T445;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Interleukin-6 {ECO:0000256|ARBA:ARBA00019464};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000020478.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000020478.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000020478.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the IL-6 superfamily.
CC {ECO:0000256|ARBA:ARBA00007432}.
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DR AlphaFoldDB; A0A493T445; -.
DR STRING; 8840.ENSAPLP00000020478; -.
DR Ensembl; ENSAPLT00000043300.1; ENSAPLP00000020478.1; ENSAPLG00000011754.2.
DR GeneTree; ENSGT00390000000878; -.
DR Proteomes; UP000016666; Chromosome 2.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR GO; GO:0005138; F:interleukin-6 receptor binding; IEA:InterPro.
DR GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR GO; GO:0072540; P:T-helper 17 cell lineage commitment; IEA:InterPro.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR003574; IL-6-like.
DR InterPro; IPR030474; IL-6/GCSF/MGF.
DR InterPro; IPR030473; IL6/GCSF/MGF_CS.
DR PANTHER; PTHR48406; INTERLEUKIN-6; 1.
DR PANTHER; PTHR48406:SF1; INTERLEUKIN-6; 1.
DR Pfam; PF00489; IL6; 1.
DR PRINTS; PR00433; IL6GCSFMGF.
DR PRINTS; PR00434; INTERLEUKIN6.
DR SMART; SM00126; IL6; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00254; INTERLEUKIN_6; 1.
PE 3: Inferred from homology;
KW Acute phase {ECO:0000256|ARBA:ARBA00022486};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 350 AA; 37670 MW; 17C6461ACE9E340B CRC64;
MTSCFCPAPL GSPPTAPFHN PAALRRGERT PPCSQPGFSQ AVNNLEAPSI NTRSGMPGAH
STRRPLVLLR RRDGAEEEEP HHELSRRLPG GEEPGAALPP LRRRPAAAAA AAASARRRRA
AAPGRRPRLL RGGRAGGGRG EASGAARLRG PGLAAARPGG PTAGGGGYGA ARGWVVVLPG
SGGCCPPPRC DARCGCLSPQ MCEKFTVCEN SMEMLVQNNL NLPKVTEEDG CLLAGFDEEK
CLKKLSSGLF TFQTYLEYVQ ETFTSEKQKV ESLCYSTKHL ATTIRQMVIN PDEVVIPDSA
TQKSLLTKLK SDKTWIEKIT THLILRDFTS FMEKTVRAVR YLKNTRSVSV
//
