ID A0A493T485_ANAPP Unreviewed; 563 AA.
AC A0A493T485;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Platelet-derived growth factor D {ECO:0000256|ARBA:ARBA00018876};
GN Name=PDGFD {ECO:0000313|Ensembl:ENSAPLP00000020646.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000020646.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000020646.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000020646.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with PDGFRB homodimers,
CC and with heterodimers formed by PDGFRA and PDGFRB.
CC {ECO:0000256|ARBA:ARBA00026039}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR AlphaFoldDB; A0A493T485; -.
DR Ensembl; ENSAPLT00000046947.1; ENSAPLP00000020646.1; ENSAPLG00000009485.2.
DR GeneTree; ENSGT00940000159575; -.
DR Proteomes; UP000016666; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR11633; PLATELET-DERIVED GROWTH FACTOR; 1.
DR PANTHER; PTHR11633:SF4; PLATELET-DERIVED GROWTH FACTOR D; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00042; CUB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT DOMAIN 242..360
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 449..555
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
FT REGION 39..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..108
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 563 AA; 62532 MW; E223228171893D24 CRC64;
MLWTFTVVVL GMGGEPMHFS PRATCGFSSC PRWLRPRASC SSWGTSSHPC PTRGGERGAP
RRGPAPSHHP SPHPFSPGRE RGEGPGTAPA RLPSLPTPGP PSPHPRAAPD PSGGCSRAGP
SRAERSRAEQ GRCEAPAAGE RGCGSPRLRP GRGRRVPAEG SLPHLAASGR PQKSSRKKKP
RSRAQRIPMQ LLILLLLYAV VCANFCSRQG TTAPAQSGSI KALRSSNIRR DESNHLTDLY
RKEETISVAG NGCIHSPRFP SSYPRNLLLT WRLHSPESTR IQLTFDNQFG LEEPENEICR
YDFVEVEDLS ETSTVIRGRW CGHKEVPPRI TSRTNQIKIT FKSDDYFVAK PGFKICYSLV
DDFQHAASET NWESVTSSVS GVSYPSPSVT DPTLTAEALD QTIAAFDTVE DLLKHFNPDS
WQEDLENLYT DSGHHYRGRS YHDRKSKVDL DRLNDDVKRY SCTPRNYSVN LREELKLTNV
VFFPRCLLVQ RCGGNCGCGT SNWKSCTCVS GKTVKKYHEV LKFVPEAGHP RRKGRTRNNM
ALVDIQLDHH ERCDCVCSSR PPR
//
