ID   A0A493T634_ANAPP        Unreviewed;       724 AA.
AC   A0A493T634;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Patched 2 {ECO:0000313|Ensembl:ENSAPLP00000021384.1};
OS   Anas platyrhynchos platyrhynchos (Northern mallard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000021384.1, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000021384.1, ECO:0000313|Proteomes:UP000016666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT   "A new Pekin duck reference genome.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000021384.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   AlphaFoldDB; A0A493T634; -.
DR   STRING; 8840.ENSAPLP00000021384; -.
DR   Ensembl; ENSAPLT00000047589.1; ENSAPLP00000021384.1; ENSAPLG00000020070.1.
DR   GeneTree; ENSGT00940000159901; -.
DR   Proteomes; UP000016666; Chromosome 8.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR   PANTHER; PTHR46022:SF3; PROTEIN PATCHED HOMOLOG 2; 1.
DR   Pfam; PF12349; Sterol-sensing; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT   DOMAIN          514..586
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          641..687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   724 AA;  77215 MW;  DA53017612A5D35B CRC64;
     MHGGGWLRVS LQREGHRGAE IPQQELRVGL STLPTPFLPW GRLSPCPPFP RCSPPRVGPP
     EERGGDVCGA AAVRGGGALA LSGWAHGEVG GLAASSGWVW RGETAAWGRS WLRGGLWGGS
     APSPGCHIPA LSPGGVRWGQ GPPAPLCVWW HWCHPTGVGR GPRCCHRAPP GLALGFCGPS
     WLRAWLASPG IPYGQGVGVG TGLWGGLGAD GAPLILPAAG SRVSQELRYT KEKLGEESVY
     TSQMLIQTPK REGENILTQE ALQLHLEAAL AASKVQVSLY GKSWDLNKIC YKSGVPIIEN
     GMIERLFPCV ILTPLDCFWE GAKLQGGSAY LPGRPDIQWS NLDPLQLMEE LGQFTSLEGF
     KELLDKAEVG QAYMERPCLD PRDPQCPPSA PNKQSHPDIP AELSGGCHGF SRKFMRWQEE
     LILGGTTKDS QGKLLSAEAL QTMFLLMSPR QLFEHFKDDY EIHDISWSEE KAGAILEAWQ
     RKFVEVGTGH SPQPLCGTAF PPLPGFHVAV GPGTLAYACV TMLRWDCSKS QGAVGLAGVL
     LVALSVASGL GLCSLLGISF NAATTQVLPF LALGIGVDDM FLLAHAEQGG LGARVVEAAL
     GDDEHVVEGE VLELRRDEGV RLGVPRHDVR QVEPVVHHGG AVEAQPQQRQ EEDHHHCLRG
     QRGQNNVPHH PCPHPGVAVP SPPHLGLGAQ QERGVLLAGE VGEAPAAEGQ GHALAPTLGL
     VQLG
//