ID A0A493T8M0_ANAPP Unreviewed; 1415 AA.
AC A0A493T8M0;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Cordon-bleu WH2 repeat protein {ECO:0000313|Ensembl:ENSAPLP00000022221.1};
GN Name=COBL {ECO:0000313|Ensembl:ENSAPLP00000022221.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000022221.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000022221.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000022221.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSAPLT00000020276.1; ENSAPLP00000022221.1; ENSAPLG00000004666.2.
DR GeneTree; ENSGT00530000063608; -.
DR OMA; MISELMM; -.
DR Proteomes; UP000016666; Chromosome 2.
DR GO; GO:0003785; F:actin monomer binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd21799; WH2_Wa_Cobl; 1.
DR CDD; cd21800; WH2_Wb_Cobl; 1.
DR CDD; cd21801; WH2_Wc_Cobl; 1.
DR InterPro; IPR039895; COBL-like.
DR InterPro; IPR019025; Cordon-bleu_ubiquitin_domain.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR47008; PROTEIN CORDON-BLEU; 1.
DR PANTHER; PTHR47008:SF1; PROTEIN CORDON-BLEU; 1.
DR Pfam; PF09469; Cobl; 1.
DR Pfam; PF02205; WH2; 3.
DR SMART; SM00246; WH2; 3.
DR PROSITE; PS50898; RBD; 1.
DR PROSITE; PS51082; WH2; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT DOMAIN 65..139
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 1266..1286
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT DOMAIN 1306..1326
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT DOMAIN 1391..1411
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 498..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 909..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1063..1233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1344..1392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..451
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 909..924
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..940
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1131..1160
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1162..1210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1358..1374
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1415 AA; 154157 MW; 225C186D98DC9E08 CRC64;
METLVRPAAG KPPSGRRMKA RAPPPPNQPS AASRINNEHK SSAETAVISD QNLVSMKENM
INRSVDFTVI LPNGVEQKTT VQGSKAVMDL LVDLCSRYHL NPSQYSLELK SLGTEQPLSY
KANTLIGALD VQTVLLKEKV PEEKIKRPLP RAPEKSVRLV VNYLKTQKAV VRVSPEVPLH
NIIPAICEKC EVSQEHIVLL RDSITGEELE LTKSLEELGI SELYAWDRKR VPPSKTQSEP
SLNYREPSRS VSLSSDAVEK EKKGFLGFFK ANRNNSKTEE HLRMNRDYGE EDVFSSTSTS
EGSLDGFSTA PNSPSVNSRS SSLGSSLSLG NISGMTANPE VKKRRAPPPP VVTPPLQNME
MSGQEKMAVQ ISQGASLNDL QKKKRRAPLP PTLSAPPTPA MPNRTEEVED KRKSTMGDGR
QVPQKPPRGI TRGPPELVIP PPPPYPPPDR DSMDPAVCYR EADVTAPTKL VPKQSLLPAH
DNAYAVDDTV MELSEVEETA SESSCFASED TTEDSGVVSS PSDIVSLDSQ NDSMKSRDIK
LVNGYMDSAE ADAMCGTETC PVKKTSCSNM GYDSASQSSK NEEITAAKHG NEDVFIDAQL
QQTLADLDED LEAMDVKSNS DSECMSEVLS PHVRKVEDPQ DVASSVPVTV IDDVPEVTIS
NSPRNQETRG SRNLLADSVS TGNFTNKNNN AGSFDKGHTD TGAVCKSKDL LHQQPSESEF
VHLPVEQRRD MFESLTSSFE KRSEKNVRLE APPRHGMKSE ECKSKLIPSH SKTTTEISTA
KEKINPYNEG SNRERTLKKS KSELEIKWPP AKKIEAEEVP STPPWCHRAQ NWGTNYEPKM
GLTTFKVVPP KPEVKHSDRG TSVSTGAIKI DELGNLINPK VVVSKNIPGS STGESEEIPL
GKVKEFWRSS SVEKQSDDSA EHLAKKPAVN TNSKSFATKQ EHKPVSPAAP KPVAPQTVTS
QVAEKPSENE KTKPPLPVTQ SQVKPLMAPA VNKDKMELPF LKPHRRTSSQ YVASAIAKHI
NLPTFKPDSA EFHEKDEYKH GAGEAKTEAE VSPKRCIIVA NSSPVETESA ETTEKNANIF
TSSQKVSHRL TPGDNSGMEN KVVNIRAPNQ ATPASFYKKN VSVPLTKSSL KDNDGTEDEH
SLNGKESIAE KKKRLLLDQK CETLPRSNSA SSLKSPDLQG VSPPFSSSLR ITKWPPTDSM
QVSSLRASPK LNGVTAKAES EQKDKPDDSL TNAVGELDVN VQTNIFGPKK KFKPVVQKPI
PKDTSLHSAL MEAIQTGGGK EKLRKVSDSA LYGNHNKPSY AEPENERSAL LAAIRGHSGT
SKLKKISSLA SEELQSFRNA ELSLQKTEDS QEELFCIPPA PAQPPPPPPP TQLSTAAPNS
SATTAGDPGE ARRALMEAIR SGAGAAKLKK VPLLV
//
