ID A0A493T8M8_ANAPP Unreviewed; 1865 AA.
AC A0A493T8M8;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Alpha kinase 2 {ECO:0000313|Ensembl:ENSAPLP00000022182.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000022182.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000022182.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000022182.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Alpha-type
CC protein kinase family. ALPK subfamily. {ECO:0000256|ARBA:ARBA00008651}.
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DR Ensembl; ENSAPLT00000043466.1; ENSAPLP00000022182.1; ENSAPLG00000018933.1.
DR GeneTree; ENSGT00940000160524; -.
DR OMA; CMEPRTE; -.
DR Proteomes; UP000016666; Chromosome Z.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.20.200.10; MHCK/EF2 kinase; 1.
DR InterPro; IPR004166; a-kinase_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR47091:SF2; ALPHA-PROTEIN KINASE 2; 1.
DR PANTHER; PTHR47091; ALPHA-PROTEIN KINASE 2-RELATED; 1.
DR Pfam; PF02816; Alpha_kinase; 1.
DR Pfam; PF07679; I-set; 1.
DR SMART; SM00811; Alpha_kinase; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51158; ALPHA_KINASE; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1440..1528
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1555..1823
FT /note="Alpha-type protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS51158"
FT REGION 299..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1308..1410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1314..1336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1394..1410
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1865 AA; 207247 MW; 53728B699FA6AB93 CRC64;
MRSSKVSFPC EKSRRRLPNM EDNMDAKNVF ETQENICCLR GASENGDDLI NFNSMVCVAA
GEAEKYCISQ VHSHPTDLIT DHTDNCCLKV EDSISCPPPA EVQTHGKTGF SRPLTMNAVL
SEQADTPVVN QNYFTKHDSE NSGGILEACA SVSDDFSDDV LEYFECSDVL TAHENEIWEK
KLQFLLESGD EDDLKLSKDC DGCAYFLSEM PCLFRVSDNT TPMDTTIGFC GHHSKFKGVN
VRRDPSTYSQ STLQAEMTLA VGQHRDKTTS VKDEEKGKVP VAPAVIKNEC LRTEEENNGI
GQTDFSTSKP QNVDNVHAKA DSSTGGIGTA LTNQASETMT ENKVDENLLG ENSLLLEEGR
RNSSEENARH AVSTLTETLT RNLLKLLNPI ELCRYVGNIG QSFQAATEVR ESSALFPSQE
GVFSAQMREE TESLQMQAGL CRTEEADKDC HWEQKKTRGP SEQNQVPDDN VSPRNQGASL
KISIQNCDRE CMEPEIAKEG ILITCQNAEN IHSASECTEK PLQAKNGSLQ TYSQHCAPCD
KRESCHQQVF WEQGKDISSN GNKSKKDISP FPLWDADSVP DKQESLCAVL SSAKLCDEPK
EGGQRYGFDS HDGNDRDTLC SVSCDESLFE ANPKSVLESG EPGCKGDADL SAVHDKLWKL
LQEDDSDYQI PFENWGITSL EVRLTDTKVT EPNSVQETCS DHPLPSNFVE QQEPITQPPT
RQRTEKEDCS VSNVLLKTDE ACNSASIENF SLTRVVEADG LCMSSSTENK TETPSTCISE
NSILNTEECF EQKPNQTLIV NNGAVQMTVS REGKLTVNNT FQTCDTDSQR LKNAQSSNLA
CDKQNSAYMS DKSRWTTGQL PHTERNISLI NENMTETTDE DAGKDCHFKD CYLERKKLVY
FPEEKVIFLS NSSVENTHQF THEKHSSVNT IHRSYENNLP EKRNHSELNA QNGTNCSSYH
PSKNYDSRDF QVVSNTQKYS YPMKLPNFIK TPETITCKNL PQNVHQMTEL EKQEVMFTAS
SESPLLTDFL VKVPKYEPSK PGKEQRAIFI GDEQRAEASC DSGVRHVSES QPAVSPHNVS
EQHLFFADNT FKFDEELKTG YLKSPTYASG NVTSVSVSTL LPRKVQNEYC TVAKADCRDI
SNQMDLQQQS VRETSPFIPV RQSEGSPNSV AAMGCSGTGS HVQTECTQTA VKGDEKLTEL
EAFCEALQDH IHRVPEENKE EAILLGNKQE IQRTTEYNLD AAKMKSPLHA LISSKAQRRI
RNSIAKQSSP DLITSSKPAE VDCSIKSTEH DKDEGVMTSE TALSALVNLP AVDSGDSRSL
QRQPPYSRTQ PHSLALATYD PFSVSAERPE NQEGSKSCQT SPTVAESEPI KCKHTAKSEN
LATGAKKKLP PATLSKKPRL EERGNVSKDP SCVRSEANMI HKENRKEQRK LILKKDSKAP
KLLKKIQAEL FPDCSGNVKL CCQFGDIHGD STITWTKDSK LLARLQRNAQ DDSPVSLAIA
KASDKDQGMY YCCLNNIYGK VTAEFNLTSE VLEHLSSFQN FEGVEEIEFM QLMFREDFIS
DSYFGGNLHG IIATEEFHFG EGMHRKAFRS KVMQGLVPVF SPGHPCVLKV HNAITYGTKS
KDDLVQKNYK LALQECYVQN TAREYAKIYA AEAEPLEGFG EVPEIIPIFL VHRPANNIPY
ATVEEELIGE FVKYSVRDGK EVNFLRRDSE AGQKCCTFQH WVYEKTNGSL LVTDLQGVGM
KLTDVGIATL AKGLYPPLTR LRGKIAWARP SQAAEPSGRR PPDTGPALGA VGGCVLQGGD
ARFLPVFSAP FGAISLQLSL ACLDLLAEDT KDSFKCYFRS SRRIARWLEC QKIKAQILLR
TSEGV
//
