ID A0A493T8N6_ANAPP Unreviewed; 756 AA.
AC A0A493T8N6;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Neural EGFL like 1 {ECO:0000313|Ensembl:ENSAPLP00000022000.1};
GN Name=NELL1 {ECO:0000313|Ensembl:ENSAPLP00000022000.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000022000.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000022000.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000022000.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A493T8N6; -.
DR Ensembl; ENSAPLT00000032625.1; ENSAPLP00000022000.1; ENSAPLG00000008616.2.
DR GeneTree; ENSGT00810000125439; -.
DR Proteomes; UP000016666; Chromosome 5.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 4.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 6.20.200.20; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24042; NEL HOMOLOG; 1.
DR PANTHER; PTHR24042:SF2; PROTEIN KINASE C-BINDING PROTEIN NELL1; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF00093; VWC; 2.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 4.
DR SMART; SM00215; VWC_out; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57603; FnI-like domain; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..756
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019727721"
FT DOMAIN 217..278
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 380..421
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 422..462
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 463..493
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 495..530
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 542..577
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 638..696
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DISULFID 465..475
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 483..492
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 756 AA; 83808 MW; 041EF74B3A9BE4A8 CRC64;
MGLLLLLWAW AAAAGAAIGF GMDPDLQIDI ITELDLVNTT LGVTQVSGLH NASKAFLFQD
IEREIHAAPH VSEKLIQLFR NKSEFTFLAT LQQKASTSGV ILSIRELEHS YFELESSGLR
DEIRYHYRFN GKSRTEVFPY RLADGQWHKI AVSLSASHLL LHVDCNRIYE RIIDPPETNL
TPESNLWLGQ RNRKHGFFKL NYAETRLSQL EDCHCEKTCQ VNGLIYRDKD SWVEDDHCRN
CTCKSGVVEC RRMSCPPLDC PPDALPVHVE SQCCKICKAK CIYGGKVLAE GQRVLTKSCR
ECRNGVLVKV TETCPPLNCS GKDHVLPENQ CCSVCRGHNF CAEGHKCGEN SECKNWNTKA
TCECKNGYLS VQGDSAYCED IDECAAKMHY CHANTVCVNL PGSYRCDCVK GYVRVDDFSC
TEHDECSSGQ HNCDENAICT NTVRGHSCTC KPGYVGNGTI CRAFCEEGCR YGGTCVAPNK
CVCPSGFTGS HCEKDIDECA EGIIECHNHS RCVNLPGWYH CECRSGFHDN GTYSLSGESC
VDIDECALKT HTCWNDSACV NLAGGFDCLC PSGPSCTGDC PHEGGFKRNG QVWTLREDRC
SVCSCKDGRI FCRRTACDCE NPSADLFCCP ECDTRVTSQC LDQTGHKLYR SGDNWTYSCQ
QCRCLEGEVD CWPLLCPNLN CEYTAISEGE CCPHCVSDPC LADNITYDIR KTCLDGYGIT
RLSGAVWTMV GSPCTTCKCK NGNVCCSVDL ECLNNN
//
