ID A0A493T8Q5_ANAPP Unreviewed; 575 AA.
AC A0A493T8Q5;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=WSC domain containing 1 {ECO:0000313|Ensembl:ENSAPLP00000022030.1};
GN Name=WSCD1 {ECO:0000313|Ensembl:ENSAPLP00000022030.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000022030.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000022030.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at
CC the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
CC as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.
CC {ECO:0000256|ARBA:ARBA00035001}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the WSCD family.
CC {ECO:0000256|ARBA:ARBA00010236}.
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DR AlphaFoldDB; A0A493T8Q5; -.
DR STRING; 8840.ENSAPLP00000022030; -.
DR Ensembl; ENSAPLT00000039019.1; ENSAPLP00000022030.1; ENSAPLG00000006092.2.
DR GeneTree; ENSGT00940000158096; -.
DR OMA; KDFEPFT; -.
DR Proteomes; UP000016666; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR InterPro; IPR002889; WSC_carb-bd.
DR PANTHER; PTHR45964:SF5; WSC DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45964; WSCD FAMILY MEMBER CG9164; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR Pfam; PF01822; WSC; 2.
DR SMART; SM00321; WSC; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51212; WSC; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT DOMAIN 140..232
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT DOMAIN 243..340
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
SQ SEQUENCE 575 AA; 65383 MW; D91190220EC4538B CRC64;
MAKAFFRLQK FLRRTQFLLF FLTAAYLMAG SLLLLQRTRL VVQQGPRGTS AGQALLVPEA
VPGAGLAEPR GAQSPSPRLL AGTAALRELA SSQRHGPHWL TARNSELRQL RRRWFHRFIS
DQEPMQTAGL KAMKRTAEHK GTYMGCFSDD SRERTLKGAV FYDLRKMTVS HCQEACAERA
YTYAGLAYGA ECYCGNKLPV TASRPEECNS ECKGEKGSIC GGVNRLSVYR VEELWAAAPR
RRNVIYRGCF RAPENLTDTF PASLIQPNLT VEMCSEFCSK KEFPLAVIRG RECYCGYPTG
RFSLHGGADR QLCSGMLNVS SAAGGKYCLV YQTPVQDTRC TDRKFLTTKS KVFVALSSFP
GAGNTWARHL IEHATGYYTG SYYFDGALYN KGFKGEKDHW RSRRTICVKT HESGKTEIEM
FDSAILLIRN PYKSLMAEFN RKFAGHLGYA TDRNWKSKEW PDFVNSYASW WASHVLDWLK
YGKRLLVIHY EDLKQSLIPK LKEMVEFLNM TVTEDRLLCV ENNRDGNFKR SGAKQKNFEP
FTQEMKDLIN RYILTVDEAL KGRNFTGLPR EYVPR
//
