ID A0A493T936_ANAPP Unreviewed; 1115 AA.
AC A0A493T936;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=DENN domain containing 1A {ECO:0000313|Ensembl:ENSAPLP00000022208.1};
GN Name=DENND1A {ECO:0000313|Ensembl:ENSAPLP00000022208.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000022208.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000022208.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000022208.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 8840.ENSAPLP00000022208; -.
DR Ensembl; ENSAPLT00000020134.1; ENSAPLP00000022208.1; ENSAPLG00000005294.2.
DR GeneTree; ENSGT00940000156261; -.
DR OMA; NTAWSGD; -.
DR Proteomes; UP000016666; Chromosome 18.
DR GO; GO:0030665; C:clathrin-coated vesicle membrane; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:Ensembl.
DR GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0032456; P:endocytic recycling; IEA:Ensembl.
DR GO; GO:0048488; P:synaptic vesicle endocytosis; IEA:Ensembl.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 6.10.140.1000; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR040032; DENND1A/B/C.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR13196; DENN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR13196:SF22; DENN DOMAIN-CONTAINING PROTEIN 1A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT DOMAIN 15..377
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 452..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..514
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..611
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..783
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1077..1094
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1115 AA; 123559 MW; AED6347EE7DF9F6F CRC64;
MGSXXRQNPE TTFEVYAEVT YSGISCIGKD PEVRRQFPED YSDQEVLQTL TKFCFPFYVD
SYAVSQVGQN FTFVLTDIDS KQRFGFCRLS SGAKSCFCIL SYLPWFEVFY KLLNVLADYS
AKGQDNQRSE LLETLHKLTI PEPGTSVHLG VHSYFTVPDI RELPSIPENR NLTEYFVAVD
VNNMLHLYAS MLYERRILIC CSKLSTLTAC IHGSAAMLYP MFWQHVYIPV LPPHLLDYCC
APMPYLIGIH LSLMEKVRSM ALEDVVILNV DTNTLETPFD DLQSLPNDVV SALKSRLKKV
STTTGDGVAR AFLKAQASFF GSYRNALKIE PGEPITFCEE TFVSHRSAVM RQFLQNAIQL
QLFKQFIDGR LDLLNSGEGF SDVFEEEINT GEYAGSDKLY HQWLSTVRKG SGAILNTVKT
KANPAMKTVY KFAKDHAKMG IKEVKNRLKQ KDVAENGCST APEQSIPRTA PSPLVEKKDP
KLREDRRPIT VHFGQQQRLR PPRPPPPKIQ RSSRPVRPPR PHVVKRPKSN IAVEGRRTSV
SSPEHLVKPM RHYTVFLSED SSDDEFQQEE DPVSGFSENF FFSAPFEWPQ PYRALKESDS
ADGEEAVSPE KAKKPLPPSP LLSSNTTEIN LLEDIFPNLE VETQPQPLSQ AKSLEDLRTP
KEEGHQRCTF DYQRMELGVA ERNRIVPPMK LSHPYNKLWS MGHDDMAIPT KYSQSSPERP
LTALGNMPPI TRRPRSRDSI LAPVEKDESN PATRGNITIP RPQGRKTPEL GIVPPPPAPR
ASKHQIPAGP TETLTAHATG RSHLVSDLIP EPFGAGRVSL DPEVQQSVNY SSHSSQLLSS
ASSTAEMLQP VKVKTDNTGN ESDYLLNLLD PLKTASWQSS GPQQGSCSLQ SSATPPSGAG
FASVASDFVP PPAAPFVQSL SYPSPALPPF LQASPFTQTF TQTAPGALSV SLVRPPRGSF
TPTLGHAYSS SFITPNSGFY PPQRPQPNIS TLSMPNLFSQ APAMAQASSL LLQSHSASPA
SSLQPACLSG PSKSRTLQVG KSSSKVDTKQ VLALLSNEPP LIPSRPAKGL ESMLQSSKSE
ETKDPFEDLL KKTKQDVSST PGKVEQLRKQ WETFE
//
