ID A0A493T9W8_ANAPP Unreviewed; 4575 AA.
AC A0A493T9W8;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=FAT atypical cadherin 3 {ECO:0000313|Ensembl:ENSAPLP00000022691.1};
GN Name=FAT3 {ECO:0000313|Ensembl:ENSAPLP00000022691.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000022691.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000022691.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000022691.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSAPLT00000041352.1; ENSAPLP00000022691.1; ENSAPLG00000013451.2.
DR GeneTree; ENSGT00940000154981; -.
DR Proteomes; UP000016666; Chromosome 1.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 33.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 33.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF422; NEURAL-CADHERIN 2-RELATED; 1.
DR Pfam; PF00028; Cadherin; 29.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 32.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 33.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 14.
DR PROSITE; PS50268; CADHERIN_2; 32.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..4575
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019769693"
FT TRANSMEM 4156..4176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..158
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 159..266
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 377..473
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 474..579
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 588..682
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 728..832
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 833..937
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 938..1044
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1052..1149
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1150..1255
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1256..1360
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1364..1461
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1462..1567
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1568..1770
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1771..1884
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1900..1987
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1984..2085
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2086..2187
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2188..2288
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2289..2395
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2396..2497
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2498..2601
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2602..2709
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2710..2815
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2816..2925
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2926..3030
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3031..3132
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3133..3237
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3238..3342
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3343..3447
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3448..3552
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3563..3654
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3796..3834
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3836..4019
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4022..4059
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4061..4097
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4099..4135
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4308..4335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4419..4441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4312..4335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 4049..4058
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4087..4096
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4125..4134
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4575 AA; 504367 MW; 3311666EFE739908 CRC64;
MEVNMGRWSG TRPPPSCLAL LIVKLLASLC QVVHGTAPLG FHFTHSTYNA TVYENSAART
YVNSQTRMGI TLADLSWDIK YRIVSGDDEG FFKAEEVIIA DFCFLRIRTK GGNSAILNRE
IQDNYLLIVK GSVRGEDLEA WTKVNIQVLD MNDLRPLFSP TTYSVTIAES TPLRTSIAQV
TATDADIGSN GEFYYYFKNK VDLFSVHPTS GVISLSGRLN YDEKNRYDLE ILAVDRGMKL
YGNNGVSSTA KLYVHIERIN EHAPTINVVT HIPFPSDKEP TYAVVNIDDL DEGANGEIES
VSIVAGDPLE QFLLTKEGKW MNEYKIKERK PIDWDSFPYG YNLTLQAKDK GSPQKFSAVK
LVHIASPKKE SIPIKFEKET YDVSINEFSP PGVVVAVIKL TPEPLGVEYR LSPSEDADYF
KINPNTGLIT TARPLKIIEK DLYELEVYTN KGGDLKAQVT VRIEDANDHT PEFQQPSYSS
FVNESVPVGY SVLAVSAVDK DRGENGYITY SIASLNSLPF IINQFTGIIS TSEELDFESS
PESYRFIVRA SDWGSPYRHE SEVNVTIYIG NVNDNKPLFE KVACQGVISS DFPVGGHITA
VSAIDIDELE LVKYKIISGN ELGIFYLNPD SGVLQLKKSL INSGIKNSNF GLKITATDGE
NFADAMFVNI SVVHGKVSSK TFSCRETRVA QKLAEKLLKK AKANVKLNLE DGFLDFYSVN
RQAPHFDKTF PTDVMVSEDL PVGATILRIK AYDADSGFNG KVVYTISDGN GDSCFNIDME
TGVLKVLMPL DREKTELYLL NITIYDLGNP QKSAWRLLTV TVEDANDNKP VFLQDSYSVN
ILESTSLGTE IIQVEARDKD LGSNGEVAYS VLTDTQQFAI NSSTGVVYVA DQLDRETKAN
YTLKIEARDK ADSGHQQFSV VPLKVFLDDV NDCSPAFIPS SYNVKVLEDL PVGTVIAWLE
THDPDLGLGG QVRYSLVNDY NGRFEIDKAS GAIRLSKELD YEKQQFYNLT VRAKDKGRPV
SLSSVSFVEV EVVDVNENLY TPYFPDFAVI GSVKENSRIG TSVLQVVARD EDSGRDGEIQ
YSIRDGSGLG RFSIDEETGV IYTADILDRE TTKSYWLTVY ATDHGVVPLY TTIEVYIEVE
DVNDNAPLTS EPIYYPAVME NSPKDVSVIQ IQAQDPDSST NEKLTYRITS GNPQNFFVIN
PKTGLITTTS RKLDREQQAE HFLEVTVSDG GTSPKQSSVW VVVQVLDEND NKPQFPEKVY
QIKLPERDRK KRGEPIYRAF AFDKDEGPNA EISYSIVDGN DDGKFFIDPK TGMVSSRKQF
TAGSYDILTI KAVDNGRPQK SSTARLHIEW IKKPAPSPVP LTFDEPFYNF TVMESDKVTE
IVGVVSVQPS NIPLWFDIVG GNYDSSFDAE KGVGTIVIAK PLDAEQRSIY NMTVEVTDGT
NIATTQVLIK VLDNNDNGPE FSQPSYDVTI SEDILPDTEI LQIEAIDRDE KHKLSYTIHS
SIDAVSVRKF RIDPSTGVLY TAERLDHEAQ DKHILNVMVR DQEFPYRRNL ARVIINVEDS
NDHSPYFTSP LYEASVFESA AIGSAVLQVT ALDKDKGENA ELIYTIEAGN TGNTFKIEPV
LGIITLLKEP DLTTMGQFVL SVKVADQGSP PLSATAIVRI SVTMADNSHP KFTLKEYQAE
INENVDIGTS VISLSAISQS TLVYEVKDGN VDGVFTINPY SGVITSQKTL DYERASSYQL
IVQATNMAGM ASNATVNIQI VDENDNPPVF LFSQYSGSIS EAAPVNSIVR SANNSPLVIR
ATDADSNQNA LLVYQIVEST AKKYFTVDSS TGAIRTIANL DHETIAHFHF HVHVRDSGNP
QLTAESPVEV TIEVTDVNDN PPVFSQAVFE TVLLLPTYVG VEVLKVKATD PDSEIPPELT
YSLIEGNLDH FLIDSSTGVL TIKNNSLSKD HYMLIVRVSD GKFYSTAMVT IMVKEAMDSG
LHFTQNFYST SISENTTNIT KIAVVNAVGN RLNEPLKYSI LNPGNKFKIK PTSGVIQTTG
IPFDREEQEL YELVVEASRE LDHLRVARVV VRVYIEDIND NAPVFVGLPY YAAVQVDAEP
GTLIYRVTAI DKDKDENGDV SYLLKEDYGH FEIDRGTGSV TLKEAFNSDL SNIEYLVVIL
AKDGGNPSLS ASVELPITIV NKAMPVFDKP FYTASVNEDV EIHTPILSIN ATSPEGQGII
YIIVDGDPYN QFNIDFDTGV LSVISPLDYE INSLFKLMVR ASDALTGARA EVTVDLIVND
VNDNPPVFDQ SAYNATLSEA SLIGTPVLQV VATDADSDNN KIVQYQIVQD TFNSTDYFHI
DSTSGLILTA RMLDHELIQQ CSLKVRATDN GFPPLSSEVL VSISITDMND NPPIFNQLIY
ESYVSELAPR GHFVTCVQAS DADSSDFDRL EYSILSGNDR TSFIMDSKSG VITLSNHRKQ
RMEPMYSLNV SVSDGLFTST AQVHIQILGA NLYSPVFSQS VYVAEVRENA APGTKVLHVK
ATDGDSGVYG QISYSIINDF AKDRFLIDNN GQILTTERLD RENLLESDIG IFLRALDGGG
RTTFCTVRVI VVDENDNAPQ FMTVEYRASV KADVGKGYLV TQVQAVDPDD GANSRITYSL
YSEASVSVAD LLEIDPDNGW MVTKGSFNQL KNTVLSFFVK AVDGGIPVKH SLIPVYIHVL
PPETILPSFS QPQYSFTIAE DTLIGSTIDI VHVTPNQGAL YSTVNGELSE NNKDGVFIIE
QDTGLLKLDK RLDHETNSAF HFKVAATIQL DKVDIVLTVD VEVKVLDIND NKPIFETASY
DAIIMEGMPV GTKLMQVKAV DADSSANGQV TYTLALESEL EKITEAFTID SNSGWISTLK
DLDHEKDPAF TFAVVASDLG EALSLSSTTL VSVTVTDIND NAPVFEHEVY RGSVKESDAP
GEVVAVLSTW DEDTSDVNRQ VSYHITGGNP KGKFALGLVQ NEWKVYVKRP LDREEQDVYY
LNITATDGLF VTQAAVEVTV TDVNDNNPVC ERVAYTALFP EDIPSNKVIL KIKAKDADIG
SNGEIRYSLY GPGNNKFFLD PENGELKSLA PLDREKIPAY NLIARATDGG GRFCQSEIHL
ILEDVNDNPP VFSSDHYTAC VYENTATKAL LTRVQATDPD VGVNRKVTYS LADSADGYFS
VDRSSGIIIL EHPLDRELQS SYNISVKASD QSIVLTLSSF ATVTITVLDI NDNPPVFERR
DYLVTVPEDT SPGTEVLSVF ATSQDIGTNA EITYLIRSGN EKGKFRINSK TGAISIFEAL
DYESCKDFYL VVEAKDGGTP ALSAVTTVNV NVTDVNDNAP KFSQVVYSAV ISEDAAVGDS
VIMLIAEDLD SPSNGQIHFS IVSGDRDNEF SVDPGLGLVK VKKKLDRERI SGYSLVIQAR
DSGTPPLSSS VTVNVDISDV NDNSPVFTPA NYTAVIQENK PVGTSILQLV VTDKDSFHNG
PPFTFTILTG NEEEEFTLDP HGVLRSAVIF KHMVATEYVL CVQAKDSGKP QQVSHTYVQV
RVIEESIHKP TAIPLEIFIV TIEDDFPGGV IGKIHATDQD VYDVLTYTLK SEQKSLFKVN
SHDGKIIALG GLDNGKYVLN VSVSDGRFQV PIDVVVHVEQ LLQEMLQNTV TIRFENVSPE
DFVGLHMHGF RRTLRNAVLS QKQDSLHIIS IQPVAGNNQL DMLFAVQMHN GGFYKPAYLI
QKLTNARRHL ENVIRISAIL EKNCSGLDCQ EQHCEQSLSI DSHSLMTYST ARISFVCPRF
YRNVRCMCNG GLCPGSNDPC LEKPCPGDMQ CVGYEANRRP FICQCPPGKL GECSGHTSLS
FAGNSYIKYR VSENSKKEEF KLALRLRTLQ SNGIIMYTRA NPCIILKIVD GKLWFQLDCG
SGPGILGISG RAVNDGSWHS VFLELNRNFT SLSLDDSYVE RRKAPLYFQT LSTDSSVYFG
AQVQVDNVRS LTDKRTTQVL SGFQGCLDSV VLNNNELPLQ NKRSSFAEVV GLTELKLGCV
LYPDACERHP CQNGGTCTSV PSGGYQCNCL SQFTGRNCES EITACFPNPC RNGGSCDPIG
NAFICNCKNG LTGVTCEEDI NECEREECEN GGSCVNIFGS FLCNCTPGYV GQYCGLRPVV
VPNIQAGHSY VGKEELIGIA VVLFVIFVLI VLFIIFRKKV FRKNYSRNNI TLVQDPATAA
LLNKSNGIQF KNIRNSGDSR NIYQEVGPPQ VPVRPMAYTP CFQSDSRNNL DKIVDGLGVE
HQEMTTFHPE SPRILTARRG VVVCSVAPNL PAVSPCRSDC DSIRKSTWDA GTERSNKGSN
SEVQSLSSFQ SDSGDDNASI VTVIQLVNNV VDTIENEVSV MDQGQNYNRA YHWDTSDWMP
SARLSDIEEV PNFETADGGS AHHGSTRELE TDYYLGGYDI DSDYPPPHEE EFMSQDQLPP
PLPEDYPDQY ETLPPSQPVS MASTLSPDCR RRPHFHPSQY LPPHQFPHET DTAGAQTGNE
FSTFAVGPSQ NTENVSAGKM PLSLHNSLDA SSSDVSASCG FDDSEVAMSD YESVEELNLE
NVHIPFVETQ HQTQV
//
