ID A0A493TAP9_ANAPP Unreviewed; 353 AA.
AC A0A493TAP9;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Trans-2,3-enoyl-CoA reductase like {ECO:0000313|Ensembl:ENSAPLP00000022763.1};
GN Name=TECRL {ECO:0000313|Ensembl:ENSAPLP00000022763.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000022763.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000022763.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000022763.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the steroid 5-alpha reductase family.
CC {ECO:0000256|ARBA:ARBA00007742}.
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DR AlphaFoldDB; A0A493TAP9; -.
DR Ensembl; ENSAPLT00000033094.1; ENSAPLP00000022763.1; ENSAPLG00000004528.2.
DR GeneTree; ENSGT00950000182886; -.
DR Proteomes; UP000016666; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd17125; Ubl_TECRL; 1.
DR InterPro; IPR001104; 3-oxo-5_a-steroid_4-DH_C.
DR InterPro; IPR039357; SRD5A/TECR.
DR InterPro; IPR049127; TECR-like_N.
DR InterPro; IPR047822; TECRL_Ubl.
DR PANTHER; PTHR10556; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; 1.
DR PANTHER; PTHR10556:SF27; TRANS-2,3-ENOYL-COA REDUCTASE-LIKE; 1.
DR Pfam; PF02544; Steroid_dh; 1.
DR Pfam; PF21696; TECR_N; 1.
DR PROSITE; PS50244; S5A_REDUCTASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 257..322
FT /note="Steroid 5-alpha reductase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50244"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 353 AA; 40232 MW; AB06C90D3928C1E8 CRC64;
MLRRQKLGAP EHKRDPAAHG GTLSMSHNNT RSFFNFSQLV LSAGNLKSPP VLKHSKITYF
EVEILDVQSK KQICIVDKVP PSSTLLDVKH KFHKACPQWY PSRVGLQLER NGPYLKDSVN
IQSLAVSSII TLYFTDLGQQ VGWTTFFLTE YTGPLLIYLL FYIRLSTIYD QVESTKNFRH
PVVHLACFCH CLHYIRHLLE TLFVHKFSGG HTPLKNMIKG CAFYWGFTSW IAYYINHPRY
TPPSFGHRQV SLAALGFLMC EAGNHFINVA LAHQNHSGSK ACFPSPTYNP FTWLFLLVSC
PNYTYEVGSW ISFTVMTQTL PAHEILSANL PRDMTVQTFD VLPSENCGGY EHY
//
