ID A0A493TAY0_ANAPP Unreviewed; 1005 AA.
AC A0A493TAY0;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Calcium voltage-gated channel auxiliary subunit alpha2delta 1 {ECO:0000313|Ensembl:ENSAPLP00000022830.1};
GN Name=CACNA2D1 {ECO:0000313|Ensembl:ENSAPLP00000022830.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000022830.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000022830.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000022830.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC family. {ECO:0000256|ARBA:ARBA00007060}.
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DR AlphaFoldDB; A0A493TAY0; -.
DR Ensembl; ENSAPLT00000043964.1; ENSAPLP00000022830.1; ENSAPLG00000003174.2.
DR GeneTree; ENSGT00940000155209; -.
DR Proteomes; UP000016666; Chromosome 1.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR CDD; cd01463; vWA_VGCC_like; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013680; VDCC_a2/dsu.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR PANTHER; PTHR10166:SF6; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-1; 1.
DR Pfam; PF08473; VGCC_alpha2; 1.
DR Pfam; PF00092; VWA; 1.
DR Pfam; PF08399; VWA_N; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022673};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1005
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019743457"
FT DOMAIN 210..387
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 1005 AA; 114207 MW; D1588AF969A22F2B CRC64;
MAAGWLLVFS LTLFQSLVMN HSSEGPFPSP TTIKSWVDKM QEDLVTLART ASGVDQLAAI
YLKYRDLYTV EANNPRQLVE IAARDIEKLL SNRSKALVRL AKEAEKYQAS HQWRDEFGNN
DIIYYNAKDD QNDPEKNDTE SGSQRIRPVF EEDPVFRRQT SYQHAAVHIP TDIYEGSSPW
VDKSRTPNKI DLYDVRRRPW YIQGAASPKD MLILVDASGS VSGLTLKLIR TSVIEMLETL
SDDDFVNVVS FNNNAQNVSC FNHLVQANVR NKKKLKEAVY KISAKGITDY KKGFSYAFEQ
LLNHSVSRAN CNKIIMLFTD GGEERAQEIF HKYNEDKKVR VFTFSVGQHN YDKGPIQWMA
CENKGYYYEI PSIGAIRINT QEYLDVLGRP MVLAGEKAKQ VQWTNVYLDA LELGLVITGT
LPVFNLTKEQ NGKINQLILG VMGVDVSLED IKKLTPRFTL CPNGYYFAID PNGYVLLHPN
LQPKNPKSQE PVTLDFLDAE LENDIKVEIR KKMIDGESGE KTFETLVKSQ DERYIDKGNR
TYTWTAVNGT DYSLALVLPS YSFYYIKAKI DEPLIQARLA NKMDSETLKL DHFDEVGYTF
LAPREYCSDV KKSENNTEFL LNFNEFIDRN TPNSPSCNTD MVIRVLLDAG FTSELAQNYW
SKLDLDGVTA RFVVTDGGIT RVFPKRAGED WLENAETYEV SFYKRSLDND NYIFTAPYYN
KSGANSYETG IMVSKAVEIT INGKLLKPAV VGIKIDATGW MENFTKTTIK SLCNSEICGC
ERNSMHVDCV ILDDGGFLLM SNRDEYTQQI GRFFGEIDPG LMRNLINMSL YAFNKSYDYQ
SVCDPEEEPK QGAGIRSAYV PTITDILHLG WWASAAAWSI LQQLFLSLTF PRFLEAADME
DDDFSAALPK TSCITEQTQY FFENDDKSFI GIVDCINCSR LYHAEKISNT NLVFIISDSQ
LLCRSCDPKP LMQAEKPDEG PNPCEMVKQP RYRKGPDVCF DEAKQ
//
