ID A0A493TBY9_ANAPP Unreviewed; 475 AA.
AC A0A493TBY9;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Melanocyte inducing transcription factor {ECO:0000313|Ensembl:ENSAPLP00000023426.1};
GN Name=MITF {ECO:0000313|Ensembl:ENSAPLP00000023426.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000023426.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000023426.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000023426.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MiT/TFE family.
CC {ECO:0000256|ARBA:ARBA00008289}.
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DR AlphaFoldDB; A0A493TBY9; -.
DR Ensembl; ENSAPLT00000018929.1; ENSAPLP00000023426.1; ENSAPLG00000011965.2.
DR GeneTree; ENSGT00940000156326; -.
DR OMA; GIPMANT; -.
DR Proteomes; UP000016666; Chromosome 13.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18926; bHLHzip_MITF; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR021802; MiT/TFE_C.
DR InterPro; IPR031867; MiT/TFE_N.
DR PANTHER; PTHR45776:SF4; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR45776; MIP04163P; 1.
DR Pfam; PF11851; DUF3371; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF15951; MITF_TFEB_C_3_N; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 260..313
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 306..347
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 17..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 52901 MW; 2B37E4B455095833 CRC64;
MASSRGVLRC GCDQGSNSEH PGASKPPLSS SSMTSRILLR QQLMREQMQE QERREQQQKQ
QAAQFMQQRV PVSQTPAINV SVPASLPPAT QVPMEVLKVQ THLENPTKYH IQQAQRQQPG
DHVMPPGTGS SAPNSPMAML TLNSNCEKEG FYKFEEQSRV ESECPALNTH SRASCMQMDD
VIDDIISLES SYNEEILGLM DPALQMANTL PVSGNLIDLY GNQSMPPPGL NISNSCPANL
PNIKRELTES EARALAKERQ KKDNHNLIER RRRFNINDRI KELGTLIPKS NDPDMRWNKG
TILKASVDYI RKLQREQQRT KELENRQKKL EHANRHLLLR IQELEMQARA HGLSLVPSTG
LCSPDMVNRV IKQEPALDNC NQDIMPHHTD LSCTTTLDLT DGTITFSDNL GNMTEPTGTY
SVPTKMGSKL EDILMDDTLS PVGVTDPLLS SVSPGASKTS SRRSSVSMED TDHAC
//