ID   A0A493TC27_ANAPP        Unreviewed;       919 AA.
AC   A0A493TC27;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=Zinc finger CCCH-type containing 12C {ECO:0000313|Ensembl:ENSAPLP00000023466.1};
GN   Name=ZC3H12C {ECO:0000313|Ensembl:ENSAPLP00000023466.1};
OS   Anas platyrhynchos platyrhynchos (Northern mallard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000023466.1, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000023466.1, ECO:0000313|Proteomes:UP000016666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT   "A new Pekin duck reference genome.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000023466.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the ZC3H12 family.
CC       {ECO:0000256|ARBA:ARBA00010922}.
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DR   AlphaFoldDB; A0A493TC27; -.
DR   Ensembl; ENSAPLT00000025085.1; ENSAPLP00000023466.1; ENSAPLG00000002854.2.
DR   GeneTree; ENSGT00940000158397; -.
DR   OMA; RSPDCRY; -.
DR   Proteomes; UP000016666; Chromosome 1.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd18729; PIN_Zc3h12-like; 1.
DR   Gene3D; 3.40.50.11980; -; 1.
DR   InterPro; IPR040546; Rege-1_UBA-like.
DR   InterPro; IPR040757; Regnase_1/ZC3H12_C.
DR   InterPro; IPR021869; RNase_Zc3h12_NYN.
DR   InterPro; IPR000571; Znf_CCCH.
DR   PANTHER; PTHR12876; N4BP1-RELATED; 1.
DR   PANTHER; PTHR12876:SF36; RIBONUCLEASE ZC3H12C-RELATED; 1.
DR   Pfam; PF18561; Regnase_1_C; 1.
DR   Pfam; PF11977; RNase_Zc3h12a; 1.
DR   Pfam; PF18039; UBA_6; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   3: Inferred from homology;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU00723}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00723}.
FT   DOMAIN          445..470
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50103"
FT   ZN_FING         445..470
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT   REGION          97..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          256..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          468..594
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..113
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..145
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        487..515
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        548..576
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   919 AA;  103221 MW;  5D7A370B9DCC54AD CRC64;
     MGRKLSFPPT PPQAPFAVLA KELSQPCSSA WEDQDSEEYG TLYIQEYKKN SKVESSTCSS
     FMGLKDHLGH DLGHLYVGST GTQINAIVPW SMAEKPTMDK VNSRKEDVVK EASEETSGSS
     SCDSEESTNS DNDSEKLNNS ASESHLLPKT HRQLCRSPCL EPHILKRNEI LQDFRIEEAQ
     IVPKEVKKPP DVVKEYQTKL EFALKLGYSE EQVQLVLNKL GTDALINDIL GELVKLGNKT
     ETDQSVTNAN TSIMREASSI ESQRSESPLQ EDVTEDGDNL RPIVIDGSNV AMSHGNKEVF
     SCRGIKLAVD WFLERGHKDV TVFVPAWRKE QSRPDALITD QEILRKLEKE KILVFTPSRR
     VQGRRVVCYD DRFIVKLAFE SDGIIVSNDN YRDLANEKPE WKKFIDERLL MYSFVNDKFM
     PPDDPLGRHG PSLDNFLRKK PIVPEHKKQP CPYGKKCTYG HKCKYYHPER GNQPQRSVAD
     ELRAMSRSTA AKTTSEGGLV KSNSVPCSTK SDGTSELKRA APKRQSDPSI RTQVYQDLEE
     KLPTKNKLET RSVPSLVSIP SSSAAKPQST APLTNGLPSG VHFPPQDQRP QGQYPPTVMM
     ATKNHGTPMP YDQYPKCESP VDVGYYSMLN AYSNLSISGP RSPERRFSLD TDYRISSVAS
     DCSSEGSVSC GSSDSYVGYS DRSYMSSPDP QLEENLKCQH MHPHGRLNSQ PFLQSYHEPL
     ARVQSYSHEE PKHHHKPPIP YLAVHLQHPV VGARSSCPSD YPASQSSPHS KAVHLGRALV
     STRIDSISDS RLYDSSPLRH RKPFAAQDGL GSWDRQSYGV DAYSYRQTYS LPSNPTQPCY
     EQFAFQSLPE QQDQAWRVPY CGIPQDPPRH QDTREKVYIN LCNIFPPDLV RIVMKKNPHV
     TDAQQLAAAI LVEKSQLGY
//