ID A0A493TEH0_ANAPP Unreviewed; 943 AA.
AC A0A493TEH0;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Integrin subunit alpha 9 {ECO:0000313|Ensembl:ENSAPLP00000024078.1};
GN Name=ITGA9 {ECO:0000313|Ensembl:ENSAPLP00000024078.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000024078.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000024078.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000024078.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A493TEH0; -.
DR Ensembl; ENSAPLT00000047763.1; ENSAPLP00000024078.1; ENSAPLG00000009236.2.
DR GeneTree; ENSGT00940000156503; -.
DR Proteomes; UP000016666; Chromosome 2.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF69; INTEGRIN ALPHA-9; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 20..943
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5019613029"
FT REPEAT 24..86
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 280..339
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 341..398
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 401..464
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 449..610
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 612..736
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 739..921
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 915..943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 943 AA; 104204 MW; 52DD30BD7FBDD0DE CRC64;
MAAGWRVLAA LLVAALARCY NVDLRLPVVF QGPNGSFFGY SVLQHYHDST RWVLVGAPKA
DSKYSTSVQS PGAVFKCRVH TNPDRRCTEL DMGRGNSRGV LCGKTCKEDR DDEWMGVSLA
RQPKAGGSVL ACAHRWKNIY YETEYILPHG FCNIIPPNLQ PNGRKLLPCY EEYKKKYGEE
HGSCQAGIAG FFTEELVIMG APGSYYWTGT VKVLNLTDNM YYKLNDDAVI ARRYTYLGYA
VTAGHFSQPT STDVVGGAPQ DGGIGKVYIF RTDRRSGSLV KIFQASGKKM GSYFGSSLCA
VDLNSDGLSD LLVGAPMFSE IRDEGQVTVY INRGNGVLDE QLVLDGDGAY NAHFGESMAA
LGDIDDDGFP DVAIGAPKED NYIGAVYIYH GDANGIVPKY SMKLSGQAIN PMLRMFGQSI
SGGVDMDGNG YPDMTVGAFL SDNVVLLRSR PVITMDISIF LPASINITAP QCHDGLQPVN
CLNVTACFRF SGKHVPGEIG LNYNLTADVA KKEKSQQPRV YFVTSGETVG QVTEKLQLLY
MQEKCEHYLA YVKRRVKDVI SPIVFEAAYS LGEHVLERGK EDKELPPLKP VLRWKKGQKI
AQRNQTVFER NCQSDDCAAD LKLQGKLLLS SVDDRTAYLA LGAVRNISLN ISISNIGDDA
YDTNVFFNFS GELFFIKMWQ KEELGIACEL LESDFLKCSV GFPFMRSKSR YEFSVIFDTS
HLSGQEETLT FLVTAQREVF PTSFFYGDSV EASNFVQLEN HECLFQSLNF TLQVYNAGPS
TLPGAFLDIS FPNRLSATGA EIFHVQQMMV GQDKGNCSFH RNRSPCVVPQ ENENIFHTIF
AFFTKSGRKV LDCERPGRSC LIIHCNLSSL AKAESCDISI YTLLNTEILK KDSSSVIQFV
TRARVQVDPD LRVVEVPNGS PEEKPECSSE AERLPSVNAG VKG
//
