ID A0A493TFL9_ANAPP Unreviewed; 560 AA.
AC A0A493TFL9;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Bridging integrator 1 {ECO:0000313|Ensembl:ENSAPLP00000024639.1};
GN Name=BIN1 {ECO:0000313|Ensembl:ENSAPLP00000024639.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000024639.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000024639.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000024639.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A493TFL9; -.
DR Ensembl; ENSAPLT00000033997.1; ENSAPLP00000024639.1; ENSAPLG00000012452.2.
DR GeneTree; ENSGT00950000182882; -.
DR Proteomes; UP000016666; Chromosome 7.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0030100; P:regulation of endocytosis; IEA:InterPro.
DR CDD; cd12139; SH3_Bin1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR003005; Amphiphysin.
DR InterPro; IPR035471; Amphiphysin-2_SH3.
DR InterPro; IPR003023; Amphiphysin_2.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46514; AMPHIPHYSIN; 1.
DR PANTHER; PTHR46514:SF4; MYC BOX-DEPENDENT-INTERACTING PROTEIN 1; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR01251; AMPHIPHYSIN.
DR PRINTS; PR01253; AMPHIPHYSIN2.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 29..276
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 487..560
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 278..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 195..222
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 279..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..351
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 560 AA; 61619 MW; 3C48343457630D49 CRC64;
MAELGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN FNKQLSEGTR
LQKDLRTYLA SVKAMHEASK KLTECLQEVY EPDWPGRDDT NKIAENNDLL WTDFHQKLVD
QALLTMDTYL GQFPDIKSRI AKRGRKLVDY DSARHHFEAL QTAKKKDETK IAKPVSLLEK
AAPQWCQGKL QAHLVAQTNL LRNQAEEELV KAQKVFEEMN VDLQEELPSL WNSRVGFYVN
TFQSIAGLEE NFHKEMSKLN QNLHDVLLGL DKQYSGNAFP IKAQPSDSTP AKANKSPSPP
PDGSPITSPE TKTVNHELEP STLEAPGASI PKSPSQLRKG PPVPPPPKVT PSKEIKQENI
ISLFDDNFVP EISVTTPSQF DAPGPFQEGA SLLDLDFDPI KPDATVGKTP TPASQSLPWD
LWEPAEAAHA GAEAAGSEAA AGAEASKTEA DSGSTSLPAV VVETFPATVN GTVEGGASSE
RADMPPGFLF KVQAMHDYTA TDSDELQLKA GDVVLVIPFE NPEEQDEGWL MGVKESDWIQ
RKELDQCRGV FPENFTERVQ
//
