ID   A0A493TG44_ANAPP        Unreviewed;      1861 AA.
AC   A0A493TG44;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=NLR family CARD domain containing 5 {ECO:0000313|Ensembl:ENSAPLP00000024862.1};
GN   Name=NLRC5 {ECO:0000313|Ensembl:ENSAPLP00000024862.1};
OS   Anas platyrhynchos platyrhynchos (Northern mallard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000024862.1, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000024862.1, ECO:0000313|Proteomes:UP000016666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT   "A new Pekin duck reference genome.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000024862.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   Ensembl; ENSAPLT00000034821.1; ENSAPLP00000024862.1; ENSAPLG00000014412.2.
DR   GeneTree; ENSGT00940000160652; -.
DR   Proteomes; UP000016666; Chromosome 12.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.533.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 7.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041210; NLRC5_atypical_Card.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   Pfam; PF18461; Atypical_Card; 1.
DR   Pfam; PF13516; LRR_6; 9.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   SMART; SM00367; LRR_CC; 11.
DR   SMART; SM00368; LRR_RI; 18.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 4.
DR   PROSITE; PS51450; LRR; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT   DOMAIN          240..376
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   REGION          122..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          198..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          988..1010
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        130..144
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..214
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1861 AA;  209023 MW;  0570DAEEEBD3AF1C CRC64;
     MQPLLQNDDL NLEVAIASTR PQLVEFLSHH QDWLLTTSQH FLPGATLRDL DGITDHREKV
     SELLDLLEKD GPDTWKQFVQ HLCMELDLPL ELEILLMSSA EEGNLSQKQE ARIDVSARSS
     VPKGFARRRR SSSAISDKDA KQKRLDSAEN YRHLLIDTVR QRYGSRRAAG AAAQEQMQPL
     AFNQAFVNLV IRQSKASRLK ERTDKPREDL PSAPEPEESV DTAMRVSDLF SSAVRSGTTK
     LIFLFGRPGT GKTMLMHRIC QKWAEGVLHQ FLFTFLFEFR QLNLLKRKLT LKELLFDLFL
     QPEESPDAVF QHLLENAQHT LIIFDGLDEF TGSMDMSSTS KEGLTLPSHM SISELFADLC
     HGKLLPGCTV LVTSRPKRLP DFLLNTVDVL AEVWGFDHKK VEEYVGHYFH HHSFKEQAIA
     HLKNNTKLLS MCLIPALCYV VCICLEYLLL KHQMSVELPQ TMTQFYIKML LIFINKQQGE
     HAVDEETQLN CNKKAILGLC DLALKGLEDK KLVFYVSDIP EDVKEFASLH GLLTVFEVKT
     SGTHPEAGYA FVHLSLQEFF AALCLMINKR VDKSYLKKKF SLKSKWTLKN EAKTEFIESF
     HIFLSGLSSK ECRTFLMLLA EQNEAWVQDK QDAILQSLKK LAATHLTGPK VIELCHCTFE
     TQDLKVAQHI GSLLNFKYEF KNFRLTPLDM SALVFVINSG QDLTHLDFAG CLMDAGCLEV
     LASCKNVEHL SFRSRRFGDD FAAALSKSLR EMGSLKKLEL TGGNITAEGL TNLVQASSQC
     LQLEEINLQD NRIRDLEVKR VLDLFSRMEK LKKVDLSNNN LSLNAVLILA KEVVTCQNAT
     ELHVRKDIVI INFSGTSGKV QRSLDLRWEE NKECVIPTRH VKLCLQDRSL SLQHAKEIVS
     ILQSCPHLSE VDLSGNKLGD EGCSCLLESL PWISISKQLD LSHNLLSING IYSLLKSVNT
     CQKTMEVEVS LCHKTAVLRF TEDKEFASPH REEPLYPTDD QQVGEEKQTP TLSKKIRLTD
     CYFQASDLEK LCAVLKECSS ISELDLSNNS LGDEGLSRLF QFLPNLKMLR SLKLDNNQIS
     LNSVFCLAQS LSTLERIKTM NLSLGHMQVV HLTFWERIRD RSTGRLRRNF LVHPKHIENG
     QCFRLRDCTL GPEDVTRLCQ ILVHCTQLTE INLSGNPLSD QSIERLLSFL PYLCHLTLLS
     IKNSTFSPRC AILFTNSIGL CERIRKVEVR SNQNAFLHLG TSTHSQKTSC SLTDCAISQG
     QIEELCGVLE QHGRLAEVDL SRNQLGDEGL RFLLDHLHRV HVTCSLNLSH NRISQDGVLH
     LINAFATSGN VTEVLVSLCS KATLLMELTS RDDPRKILSL TECNFQAEHL EKLWLVLEKC
     TSLTEYISSS NNLTVHAAER LLHSLRKTSG PLKISIKEPW VCKKSVMNLL ELAVQACGNI
     TAITICKDKS LFQLGVSFPC CLEKVESVVS SLNLHEPEIK RACFYQRVLE KCIQLQELRW
     SHVELHDDDT KILVTVLLPL PKLKKFELTS CSIMPTGIDY LITGLQKCQA IEELSLGHMK
     LSDAAIPMLV LGLCKMPSLK RLILNHNSIG NDGCSRLAEA LRNMHCMEEI NLAHNKIGDP
     GLINIATVLL ELQNLKRINL SGNSPSPTGG EKLMEALACC KHIEELLLSR NVFGDGVAVK
     LALCLPHVSS LKILHLQKNN IGPTGGTELA RALVACGLLE EISLSENDLG EGSIHALSEG
     LPRLEHLRKI DLKLCGITDD SSKSLSCAFQ QCPAMEEIIL SWNSLGDGGA QELASALPGM
     EKLKMLDLEK NRIGARGAVK LSEELVKCPE IQFIRLWENP VPKGLAADLT SQDPRLCFSF
     Y
//