ID A0A493TI76_ANAPP Unreviewed; 2132 AA.
AC A0A493TI76;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Spectrin beta chain {ECO:0000256|PIRNR:PIRNR002297};
GN Name=SPTB {ECO:0000313|Ensembl:ENSAPLP00000025586.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000025586.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000025586.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000025586.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826, ECO:0000256|PIRNR:PIRNR002297}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSAPLT00000043960.1; ENSAPLP00000025586.1; ENSAPLG00000015736.2.
DR GeneTree; ENSGT00940000158908; -.
DR OMA; EPADMTS; -.
DR Proteomes; UP000016666; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0008091; C:spectrin; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:UniProtKB-UniRule.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-UniRule.
DR CDD; cd21246; CH_SPTB-like_rpt1; 1.
DR CDD; cd00176; SPEC; 9.
DR Gene3D; 1.20.58.60; -; 12.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR016343; Spectrin_bsu.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF248; SPECTRIN BETA CHAIN, ERYTHROCYTIC; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00435; Spectrin; 16.
DR PIRSF; PIRSF002297; Spectrin_beta_subunit; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00150; SPEC; 17.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 13.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467,
KW ECO:0000256|PIRNR:PIRNR002297};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR002297}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR002297};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR002297};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 52..156
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 171..276
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 2083..2132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 455..525
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1833..1860
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2083..2113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2114..2132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2132 AA; 243194 MW; EF1AE916716687DC CRC64;
MTSENDYDHM EVQQSHSYSL WDASDDELDN DNSSARLFER SRIKALADER EAVQKKTFTK
WVNLHLACVT CRISDLYLDL RDGRMLIKLL EVLSKEMLPK PTKGRMRIHC LENVDKALQF
LKEKQVHLEN MGSHDIVDGN HRLILGLIWT IILRFQIQDV IKEMKEGPET RSPRDALLLW
CQMKTAGYPH VNITNFTSSW KDGLAFNALI HKHRPELFEF KTLTKSNARH NLEHAFSVAE
RHLGITPLLD PEDVFTENPD EKSIITYVVA FYHYFSEMKK LEVKGRRLGK VIEHAKETER
MIEGYGGLAS DLLTWIEQTI VSLNSRNFAN SLAGVQHQLQ AFSTYRTVEK PPKFQEKGNL
EVLLFTIQSR MRANNQRVYT PHEGRLVCDI NRAWEQLERA EHERELALRN ELIRQEKLEQ
LARRFDLKAS MREAWLSENQ QLVAQENFGQ DLPAVEAAKK KHEAIETDTA AYKERVQAIE
AVAKELEAEG YHDIKRIKGR KDNILRLWEQ LQELLRARRQ RLEMNLTLQH LFQEMLHSID
WMDEVKAQLA SPESGKHLLE VEELLETHRL LEGDMALQME KVRAVSAAAL RFADAEGYRP
CDPKVIRDRV SHLDMCRREL QALAARRKAL LEQSRALWQC LRELDEAEDW IKEQEQICSA
LDYGKDLAGV LLLQRRHAAL EAELEARGAR LERALMAAKR LADAGREAGL LQDRAATVRA
LWVQLQELVA FRRRGLRDAE GFFQFQAEAE ELAEVLADAR RRAASEELGH DEARTQALLR
EHQELLEELV ATRQLLERLG HQAEGFPPEL QAGPEAQSRL AALRALHAEV VGLAELRGRR
LQDALDLYTV FGESEACHLW MASKERWLEK LEVPAALEDL DLVQHRLDGL EQEMAGVAPQ
IDAVNRAADG LLESGHPRSP QVRQCQQQLN ERWGRFRELV SRRRAAVGSA LSLLNYQLEC
EETRSWLLGK TRVVESTRDL GRDLAGVLAT QRKLYGIERE LAATESRLAA LRPQAARLAE
ERPELAEDVA GRLAAAQDAM DGLQGALRDR AATLGEVGQL QSFLQDLDDF QAWLFGAQKA
VAATEEVPVS VAEAEELLQR HEAARQDAEG HAAAFEALVE AGERVTRGQE DPEYEQLRER
LRGVEAGWGA LRKMWDARQR FLAQCLGFQE FLRDAKQAEI LLTNQEYTLA HLELPTTLEG
SVAALRRFED FHASMESSAE KVPSVVANGT KLVAEGNIFS EKITEKCKAL QERHQAIVAK
AQEAAGLLQD NHELQSFLQS CRELAAWVEE KMLTAQDASY GEARGLHSKW QKHQAFMAEL
AANRGWMEKV EEEGTELASR KPQYGAVVGQ RLGELRALWD GLHAAAEEKG RQLFEANRAE
LCAQSYGDLE RWLGQAEGEL RAAERAEDLT SANLMLKRLT RLEEQVGARQ EELAELVAPL
AGAAPEPDGQ EQRLQQRFLE LLEPLGRRRR ELETSKAMYQ LARDLEDETL WVQERMPRAR
STDHGTDLQS VQRLAKRNET LQKELQGHAP RLAEVLARGE AAAEGPCPEL AERAQELRVQ
WEALREEVAA RQRRLQEAGE AQQYYMDAGE AEAWVSEQEL FMGDEEKPKD EESGLVMLKR
HVRQQRSIED YGQTIKELAG RAQQLLSAGH PEGEQIIRLQ GQVDKHYAGL KEAAEERRRR
LENMCHLFQL KREVEDLEHW IAERDVVASS QELGQDLDHV TLLREKFREF ARETGSVGQE
RVDRVNLAIE DLIDAGHTEA ATMAEWKDGL NESWADLLEL IDTRMQLLAA SYDLHKYFYD
GAELLALIAD RHQELPQDLG DDSGSVEAFH RMHSAFERDL QLLETQVQQF REAAARLQTA
YAGEKAASIQ QLEQEVARAL RALLEACSGR RARLVDTADK FRFFSMARDL LSWMESTTRQ
IQTQEKPRDV SSVELLMKYH QGIHAEIDAR SKNFTTCIEL GKKLLQRKHQ ESPEIKAKLM
ELLDKRKAMM ELWQQRWDRL RLLLEVCQFS RDASVAESWL VAQEPYLASS DYGQTVDGVE
KLLKRHEAFE KSTATWEERI AALRKLTTLE LLGGRTLRDE EVTHDAAPEY RLDLDAELEA
GSEEEDEKRK GVTPQDTSPP TTDGLQPVSS GF
//
