ID A0A493TKV2_ANAPP Unreviewed; 765 AA.
AC A0A493TKV2;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Rho GTPase activating protein 26 {ECO:0000313|Ensembl:ENSAPLP00000026484.1};
GN Name=ARHGAP26 {ECO:0000313|Ensembl:ENSAPLP00000026484.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000026484.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000026484.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000026484.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A493TKV2; -.
DR Ensembl; ENSAPLT00000046468.1; ENSAPLP00000026484.1; ENSAPLG00000006831.2.
DR GeneTree; ENSGT00940000157254; -.
DR Proteomes; UP000016666; Chromosome 14.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR CDD; cd04374; RhoGAP_Graf; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF4; RHO GTPASE-ACTIVATING PROTEIN 26; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT DOMAIN 250..354
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 368..553
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 556..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..668
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 765 AA; 86163 MW; 5EAB0528C35DBB69 CRC64;
MYTCWGPSLR KSSRLGVPLP RQLLGLGVRE PGRVAWDLSS AKRKFADSLN EFKFNCIGDA
ETDDEICIAK SLQEFATVLR NLEDERMRMI ENASEVLITP LEKFRKEQIG AAKDAKKKYD
KETEKYCGVL EKHLNLSSKK KESQLQEADS QVDLVRQHFY EVSLEYVFKV QEVQERKMFE
FVEPLLAFLQ GLFTFYHHGY ELAKDFSDFK TELTISIQNT RNRFEGTRSE VESLMKKMKE
NPHEHKNLSP NTMEGYLYVQ EKRHFSTAWV KHYCTYERES KRITMVPFDQ KSGGKAGEDE
AVILKSCTRR KTDSIEKRFC FDVEAVDRPG VITMQALSEE DRRLWMEAMD GREPVYNSNK
DNQSEGTAQL DNIGFSIIKK CIHAVETRGI NEQGLYRIVG VNSRVQKLLS ILMDPKTATE
TETEICAEWE IKTITSALKT YLRMLPGPLM MYQFQRSFIK AAKLENQESR VSEIHSLVHR
LPEKNRQMLH LLMNHLAKVA NNHKQNLMTV ANLGVVFGPT LLRPQEETVA AIMDIKFQNI
VIEILIENHE KIFNTVPETP PSNSQLLLSR KKSTDSKPPS CSERPLTLFH TAQPNEKQEN
RNSIINSSLE SVVSSNANSF LNSNSSPQPN LNSSDLELEV IKPNRPNSLP QNPSPTSPLS
PSWPMFSAPS SPMPTSSTSS DSSPISSPLR KARALYACKA EHDSELSFTA GTVFDNGECP
LRPRGAGPGG SGAGVPGGRL PELGTEQGKG TAGGQRGNWG VGDMP
//