ID A0A493TLX1_ANAPP Unreviewed; 1183 AA.
AC A0A493TLX1;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Tight junction protein 2 {ECO:0000313|Ensembl:ENSAPLP00000026788.1};
GN Name=TJP2 {ECO:0000313|Ensembl:ENSAPLP00000026788.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000026788.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000026788.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000026788.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR AlphaFoldDB; A0A493TLX1; -.
DR Ensembl; ENSAPLT00000034655.1; ENSAPLP00000026788.1; ENSAPLG00000002087.2.
DR GeneTree; ENSGT00940000158634; -.
DR Proteomes; UP000016666; Chromosome Z.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12027; SH3_ZO-2; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR005417; ZO.
DR InterPro; IPR005419; ZO-2.
DR InterPro; IPR035598; ZO-2_SH3.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR PANTHER; PTHR13865:SF26; TIGHT JUNCTION PROTEIN ZO-2; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01597; ZONOCCLUDNS.
DR PRINTS; PR01599; ZONOCCLUDNS2.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 34..121
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 296..374
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 500..581
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 595..660
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 681..867
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 148..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 913..1073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1111..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..691
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..972
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1002
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1024
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1149..1183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1183 AA; 132476 MW; DE8599D01221E422 CRC64;
MGATQGSAGR EPRGPAAGEE QAPGMEELIW EQYTVTLQKD SKRGFGIAVS GGRDNPHFEN
GETSIVISDV LPGGPADGLL QENDRVVIVN GTPMENVPHS FAVQQLRKSG KVATIVVKRP
RKVQAAALRR SPSLDYEDRA LDVMDDHADF DGKSARSGYS ERSWRSGNGG RSQSWGNSLD
QSYRDDEDRG RNKSRDRSRE YSRDRSRGRS VDRSLDRDYG RDRSRGRSID RDGGYERDYR
GDYSPPSYSH GSQPDPRYVR EVRSRSRDRL RSRSPSPEMH HQHEYLGPQD QNGPISVLLT
KGKHNEEYGL RLGSQIFIKE MTSTGLATKD GNLHEGDIIL KINGTVTENM SLSDARKLIE
KSRGKLQLVV LRDRKQTLLN IPSLNDSDSE MDDISEIESN RSFSPQDDRL HHSDVDSHSS
NEKLKEKPNA KDDSSSRMSR MGAMPTPFKS TGDIASAAVT VVDTNKEPKY QDDTAVSQPK
PVARTILKPS PEDEAIYGPN TKMVRFKKGD SVGLRLAGGN DVGIFIAGIQ EGTSADQEGL
QEGDQILKVN TQDFRGIVRE DAVLYLLEIP KGETVTILAQ SKYEVYRDIM ACGRGDSFFI
RSHFECDKES PQSLAFTRGE IFRVVDTLYD GKLGNWLAVR IGNELEKGLI PNKSRAEQMA
SVQNAQKDGS SDRADFWRTR GQRSGGKKNL RKSREDLTAI VSVSTKFPAY ERVQLREAGF
KRPVVIFGPI ADVAMEKLSN DLPHLYQTAK TEPRDAGSEK STGVVRLNTV RQIIEQDKHA
LLDVTPKAVD LLNYTQWFPI VVFFNPDSKQ GVKIMRQRLC STSNKSSRKL YEQANKLKKN
CSHLFTATIN LNSANDSWYG SLKDTIQQQQ GEAVWVSEGK MDGMEDDADD RMSYLTAMGA
DYLSCDSRLI SDLEDTDGEG GAYTDNELDE TMDEPRISSV SRSSEPAHHE ENIRKLSSEP
RAQLRKAGSR EILREPSPPP AFKPEPPKGK LQNKEDQYDI PKNSDSKTSS INASSETSTA
SVKAAPPVSA KPAFGRPILR NTQQAVPAAE EEEEKLEEEG SEQENTPKSV QRKVKIFEEM
NQKAKIQRMQ ELQEAQNARL EIAQKHPDIY AVPVKTQKSE QNWPQPMSCR PPEPQKPPTR
PYLENRGSCG SDAEEEEEYR RQLSDHSKKG YYAQPSRYRD TEL
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