ID A0A493TMF0_ANAPP Unreviewed; 1517 AA.
AC A0A493TMF0;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Slit guidance ligand 1 {ECO:0000313|Ensembl:ENSAPLP00000027014.1};
GN Name=SLIT1 {ECO:0000313|Ensembl:ENSAPLP00000027014.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000027014.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000027014.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000027014.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSAPLT00000025886.1; ENSAPLP00000027014.1; ENSAPLG00000013620.2.
DR GeneTree; ENSGT00940000157322; -.
DR Proteomes; UP000016666; Chromosome 6.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 4.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45836:SF23; LRRCT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR Pfam; PF00008; EGF; 4.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF13855; LRR_8; 7.
DR Pfam; PF01463; LRRCT; 4.
DR Pfam; PF01462; LRRNT; 2.
DR SMART; SM00041; CT; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00368; LRR_RI; 3.
DR SMART; SM00365; LRR_SD22; 8.
DR SMART; SM00369; LRR_TYP; 18.
DR SMART; SM00082; LRRCT; 4.
DR SMART; SM00013; LRRNT; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00022; EGF_1; 9.
DR PROSITE; PS01186; EGF_2; 8.
DR PROSITE; PS50026; EGF_3; 9.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR PROSITE; PS51450; LRR; 6.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..1517
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019765988"
FT DOMAIN 907..942
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 944..983
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 985..1021
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1023..1061
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1063..1099
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1107..1143
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1146..1319
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1320..1354
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1357..1393
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1398..1434
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1439..1517
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT DISULFID 932..941
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 973..982
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1011..1020
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1051..1060
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1089..1098
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1133..1142
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1322..1332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1344..1353
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1361..1371
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1383..1392
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1402..1412
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1424..1433
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1517 AA; 165373 MW; 2FBBAE9F1FF44208 CRC64;
MAATPTPGGA AGVPAGLRVA AWLLACAALC RGPPAAACPP LCACSGTTVD CHGTALRAVP
KSIPRGTERL ELNGNNITRI HKNDFSGLKQ LRVLQLMENQ ISMVERGAFD DLKELERLRL
NRNQLHALPE LLFQHNQALS RLDLSENFIQ AIPRKAFRGA TDLKNLQLDK NQISCIEDGA
FRALRGLEVL TLNNNNITSI PVSSFNHMPK LRTFRLHSNH LFCDCHLAWL SQWLRQRPTI
GLFTQCAAPA QLRGLNVAEI QKNEFSCSGQ TEGARAQLCS LSSGSCPAMC TCSNGIVDCR
GKGLTAIPAN LPETMTEIRL ELNGIKSIPP GAFSPYKKLR RIDLSNNQIS EIAPDAFQGL
RSLNSLVLYG NKITDLPKGV FGGLFALQLL LLNANKINCV RADAFQDLQN LSLLSLYDNK
IQSLAKGTFT SLRAIQTLHL AQNPFVCDCN LKWLADFLRA NPIETSGARC ASPRRLANKR
IGQIKSKKFR CSAKEQYFIP GTEDYQLNSE CNSDVGCPLK CRCESGVVEC SNLKLTKIPE
RIPQSTAELR LNNNEISVLE ATGIFKKLPH LKKINLSNNK VSEIEDGAFE GAASVSELHL
TVNQLESVRS GMFRGLDGLR TLMLRNNRIS CIHNDSFTGL RNVRLLSLYD NQISTIAPGA
FDTLQSLSTL NLLANPFNCN CQLAWLGDWL RKRKIVTGNP RCQNPDFLRQ IPLQDVAFPD
FRCEEGQEET SCIPRPQCPQ ECTCLDTVVR CSNKHLKALP RGIPKNVTEL YLDGNQFTQV
PGQLSTFKYL QLVDLSNNRI SSLSNSSFTN MSQLTTLSLH GNDISSLPEG IFADVTSLSH
LAIGANPLYC SCNLRWLSSW VKTGYKEPGI ARCAGPPDME GKLLLTTPAK KFECQGPPAL
SVQAKCNPCL SSPCQNQGTC HNDPLGSYRC ACPAGYKGRD CEVALDSCSS KPCANGGTCQ
PQEGEGAGFR CLCAAGFEGP SCHAISDPCK EHSCENRGSC VPGATNYTCL CPAHYTGDFC
EQPPDFCSAE LSPCQHGSTC ISTSQGPRCE CVPGYVGSNC SEDFDDCQDH RCQNNARCVD
EVNGYSCLCT EGYSGQLCEM PPRAAGQPGP CERAECQNGA ACVERGARAL CQCLPGFGGP
KCEKLLSVNF VDRDTYLQFT DLQDWPRANI TLQVSTAEGN GILLYNGDSD HMAVELYQGH
VRVSYDPGTH PSSAIYSAET INDGQFHTVE LVTFDQMVNL SIDGGSPMTM DNSGKHYTLN
SEAPLYVGGM PVDVNSAAFR LWQLLNGTSF HGCIRNLYIN NELQDFTKTR MTPGVVPGCE
PCRKLYCLHG ICQPSGAHGP VCHCEPGWDG PHCDQPRGGP CQGHKCVHGL CLPLDALSYS
CQCHQGYQGA LCNQPAAPPD PCRLLPCRHG RCRLAPGGQP TCECHSGYTG TLCDQELECR
GEPVRDYHQV QRGYAICQTT RPVAWVQCRG ACGGDTGAGC CTGLRPRRRK YAFECSNGAT
FVEEVEKPSK CGCSQCL
//
