ID A0A493TQA0_ANAPP Unreviewed; 1610 AA.
AC A0A493TQA0;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=IQ motif containing GTPase activating protein 1 {ECO:0000313|Ensembl:ENSAPLP00000027770.1};
GN Name=IQGAP1 {ECO:0000313|Ensembl:ENSAPLP00000027770.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000027770.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000027770.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000027770.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSAPLT00000044274.1; ENSAPLP00000027770.1; ENSAPLG00000011175.2.
DR GeneTree; ENSGT00950000183076; -.
DR Proteomes; UP000016666; Chromosome 11.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001202; WW_dom.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR PANTHER; PTHR14149:SF15; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT DOMAIN 43..158
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 686..713
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 1052..1192
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT COILED 167..194
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 262..298
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1610 AA; 184073 MW; 43CEE7766269FE24 CRC64;
MAAEEVDGLA ISRPHYGSVL DNERLTAEEM DERRRQNVAY EYLCHLEEAK RWMEACLNEE
LPPTTELEEG LRNGVYLAKL GNFFSPKVVS VKKIYDREQT RYKATGLHFR HTDNVIQWLN
AMAEIGLPKI FYPETTDIYD RKNMPRCIYC IHALSLYLFK LGLAPQIQDL YGKVDFTEEE
ISNMRLELEK YGIQMPAFSK IGGILANELS VDEAALHAAV IAINEAIDHQ VPADTLMAMK
NPNAMLINLD DQLESTYQDT LYRAKQDKME NAKNRIASEN SERERDVYEE LLTQAEIQGN
INKVNTHAAI SKIGLALEQG DALALYEALA TPALGLRGLL RENCDWYFKQ FLSDRQQKKE
AGLTGLLQKE ELQLGVDAAN RAAQQYQQRL AAVAKINSAI RMGDAEKTVA EMMNPEAQLP
EVYAFAAALY QRELSTLQQQ SHEGNLTHPE LSVAVEMLSS VALINRALDS GDVNTVWKQL
SSPVTGLTNI EDENSQRYID DLIKLKSQTR AEGNEFITWN DIQSCVDRVN LAVHEEHERI
LAIGLINEAL DEGDTKKTLQ ALQIPAAKLE GVAPKVAQHY QDTLLRAKRE KAQDTQDETA
VLWLDEIQDG IHRANKDTEE SQRFSLGILA INEAVDHGDV GHTLSALRSP DVGLYGVTPE
CAETYQRELA EVKSGKMATG GNGSEWVKLW VRGGYNYYHN LRTKEGGWDE PDGFVQNDTQ
LSREEIQSTI SGVTAAYNRE QLWLANENLI TKLQACCRGY LVRQEFNSRM NFLKKQVPAI
TCIQSQWRGY KQRKAYQIRL DYLRAHKDQV VKIQSMTRMY QARRRYRDRL QYFRDHINDV
IKIQAFIRAN KAREDYKTLI NAENPPMAVV RKFVHLLDQS DQDFQEELEL MKLREEVVTL
IRSNQQLEND LNLMDIKIGL LVKNKITLQD VVSHSKKLTK KNKEQLSDMM MLNKQRGGLK
ALSKEKREKL EAYQHLFYLL QTNPTYLAKL IFQMPQNKST KFMDSVIFTL YNYASNQREE
YLLLRLFQTA LQEEIKSKVD QIHEIVTGNP TVIKMVMESQ TGEASKLPYD VTPEQALNHE
EVRTRLDASI RNMRTVTDKF LSAIVSSVDK IPYGMRFIAK VLKDSLYEKF PDAGEDELLK
IVGNLLYYRY MNPAIVAPDA FDIIDLSAGG QLTTDQRRNL GSIAKMLQHA ASNKMFMGDN
AHLSIINEYL SQSYQKFRRF FQAACEVPEL QDKFNIDEYS DLVTLTKPVI YISIGEIINT
HTLLLDHQDA IAPEHNDPIH ELLDDLGEVP TIESLIGEGS GNVNDPNREM LAKTEVSLTL
TNKFDVPGDE NAEMDARTIL LNTKRLIVDV IRFQPGETLT EILETPATSE QEAEHQRAMQ
KRAIRDARTP DKMKKSMSVR EDSNLNLQGK KEKIKTGLKK LTELGIVNAK NKYQELINDI
AKDIRNQRRY RQRRKAELVK LQQTYSALNS KATFYGEQVD YYKSYIKTCL DNLASKGKVS
KKPREMKGKS SKKISLKYTA ARLHEKGVLL EIEDLQVNQF KNVIFEISPT EEVGDFEVKA
KFMGVQMETF MLHYQDLLQL QYEGVAVMKL FDRAKMAHYI EGLWRTFITA
//
