ID   A0A493TTW8_ANAPP        Unreviewed;       766 AA.
AC   A0A493TTW8;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Sodium channel epithelial 1 subunit gamma {ECO:0000313|Ensembl:ENSAPLP00000029311.1};
GN   Name=SCNN1G {ECO:0000313|Ensembl:ENSAPLP00000029311.1};
OS   Anas platyrhynchos platyrhynchos (Northern mallard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000029311.1, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000029311.1, ECO:0000313|Proteomes:UP000016666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT   "A new Pekin duck reference genome.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000029311.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane
CC       {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004424}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. SCNN1G subfamily. {ECO:0000256|ARBA:ARBA00038067}.
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DR   AlphaFoldDB; A0A493TTW8; -.
DR   STRING; 8840.ENSAPLP00000029311; -.
DR   Ensembl; ENSAPLT00000047072.1; ENSAPLP00000029311.1; ENSAPLG00000013925.2.
DR   GeneTree; ENSGT00940000160352; -.
DR   Proteomes; UP000016666; Chromosome 15.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0034706; C:sodium channel complex; IEA:Ensembl.
DR   GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0050699; F:WW domain binding; IEA:Ensembl.
DR   GO; GO:0071468; P:cellular response to acidic pH; IEA:Ensembl.
DR   GO; GO:1904045; P:cellular response to aldosterone; IEA:Ensembl.
DR   GO; GO:0006883; P:intracellular sodium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0050891; P:multicellular organismal-level water homeostasis; IEA:Ensembl.
DR   GO; GO:0098719; P:sodium ion import across plasma membrane; IEA:Ensembl.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR004724; ENaC_chordates.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00859; ENaC; 1.
DR   PANTHER; PTHR11690:SF19; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 2.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT   TRANSMEM        54..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          536..556
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          575..624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   766 AA;  86398 MW;  82496C35AE9671C3 CRC64;
     MAPGKKITAR IKRTLPVRGP QAPTLSELMR WYCLNTNTHG CRRIVVSRGR LRRFIWILLT
     LSAVGLILWQ CAELLLNYYS ASVSVTVQFQ KLPFPAVTIC NINPYKYSSM KDYLSELDKE
     TKKALETFYG FSEGKSKVRR SAGDWNETES HFFNQIPLLK FEDFSRTATD LRSGRKRKIE
     GSVFHKDSSI VNSGDSNDII GFQLCDANNS SECALYTFSS GVNAIQEWYK LHYMNIMAQI
     PLETKEELSY SADDLLLTCF FDGLSCDKRH FTRFHHPLHG NCYTFNSGEN GTILSTSTGG
     SEYGLQVVLY IDEADYNPFL VTSTGAKIIV HDQDEYPFIE DIGTEIETAA ATSIGMHFTR
     SRKLSKPYSD CTETGADIPV ENLYNKSYSL QICLHSCFQK AMVESCGCAQ YTQPLPAGAE
     YCNYKKNPNW MYCYYRLHEK FVKEQLGCQQ ICKDACSFKE WALTTSIAQW PSIVSEDWML
     RVLSWDKGQK INKLNKTDLA NLMVFYKDLN ERFISENPTN TVSTHQEDSL SSCQAGGFHL
     ATGGSRPGRG RKPGAAWGAQ SCSFTALLPG TFSRHPNPMG YPEHVQSSPA SHHSRVGRRG
     PHRQQGKGSR HSVPNPGHSI PAGTHPQELL TSCSLLFQIV ILLSNFGGQL GLWMSCSVVC
     VIEIVEVFFI DSLSIVMRRQ WQKAKKWWND RKREGSGKHQ VGDVERQGHD NPVCIDEDLP
     TFNTALRLPL PQESHLPRTP PPNYSTLRLE TAFTEQLPDT LEAGQH
//