ID A0A493TTW8_ANAPP Unreviewed; 766 AA.
AC A0A493TTW8;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Sodium channel epithelial 1 subunit gamma {ECO:0000313|Ensembl:ENSAPLP00000029311.1};
GN Name=SCNN1G {ECO:0000313|Ensembl:ENSAPLP00000029311.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000029311.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000029311.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000029311.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004424}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. SCNN1G subfamily. {ECO:0000256|ARBA:ARBA00038067}.
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DR AlphaFoldDB; A0A493TTW8; -.
DR STRING; 8840.ENSAPLP00000029311; -.
DR Ensembl; ENSAPLT00000047072.1; ENSAPLP00000029311.1; ENSAPLG00000013925.2.
DR GeneTree; ENSGT00940000160352; -.
DR Proteomes; UP000016666; Chromosome 15.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0034706; C:sodium channel complex; IEA:Ensembl.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:Ensembl.
DR GO; GO:0050699; F:WW domain binding; IEA:Ensembl.
DR GO; GO:0071468; P:cellular response to acidic pH; IEA:Ensembl.
DR GO; GO:1904045; P:cellular response to aldosterone; IEA:Ensembl.
DR GO; GO:0006883; P:intracellular sodium ion homeostasis; IEA:Ensembl.
DR GO; GO:0050891; P:multicellular organismal-level water homeostasis; IEA:Ensembl.
DR GO; GO:0098719; P:sodium ion import across plasma membrane; IEA:Ensembl.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR InterPro; IPR020903; ENaC_CS.
DR NCBIfam; TIGR00859; ENaC; 1.
DR PANTHER; PTHR11690:SF19; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 2.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT TRANSMEM 54..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 536..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 766 AA; 86398 MW; 82496C35AE9671C3 CRC64;
MAPGKKITAR IKRTLPVRGP QAPTLSELMR WYCLNTNTHG CRRIVVSRGR LRRFIWILLT
LSAVGLILWQ CAELLLNYYS ASVSVTVQFQ KLPFPAVTIC NINPYKYSSM KDYLSELDKE
TKKALETFYG FSEGKSKVRR SAGDWNETES HFFNQIPLLK FEDFSRTATD LRSGRKRKIE
GSVFHKDSSI VNSGDSNDII GFQLCDANNS SECALYTFSS GVNAIQEWYK LHYMNIMAQI
PLETKEELSY SADDLLLTCF FDGLSCDKRH FTRFHHPLHG NCYTFNSGEN GTILSTSTGG
SEYGLQVVLY IDEADYNPFL VTSTGAKIIV HDQDEYPFIE DIGTEIETAA ATSIGMHFTR
SRKLSKPYSD CTETGADIPV ENLYNKSYSL QICLHSCFQK AMVESCGCAQ YTQPLPAGAE
YCNYKKNPNW MYCYYRLHEK FVKEQLGCQQ ICKDACSFKE WALTTSIAQW PSIVSEDWML
RVLSWDKGQK INKLNKTDLA NLMVFYKDLN ERFISENPTN TVSTHQEDSL SSCQAGGFHL
ATGGSRPGRG RKPGAAWGAQ SCSFTALLPG TFSRHPNPMG YPEHVQSSPA SHHSRVGRRG
PHRQQGKGSR HSVPNPGHSI PAGTHPQELL TSCSLLFQIV ILLSNFGGQL GLWMSCSVVC
VIEIVEVFFI DSLSIVMRRQ WQKAKKWWND RKREGSGKHQ VGDVERQGHD NPVCIDEDLP
TFNTALRLPL PQESHLPRTP PPNYSTLRLE TAFTEQLPDT LEAGQH
//