ID A0A493TUJ9_ANAPP Unreviewed; 1293 AA.
AC A0A493TUJ9;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Telomerase reverse transcriptase {ECO:0000256|ARBA:ARBA00016182, ECO:0000256|RuleBase:RU365061};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493, ECO:0000256|RuleBase:RU365061};
DE AltName: Full=Telomerase catalytic subunit {ECO:0000256|ARBA:ARBA00032044, ECO:0000256|RuleBase:RU365061};
GN Name=TERT {ECO:0000313|Ensembl:ENSAPLP00000029573.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000029573.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000029573.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000029573.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the
CC replication of chromosome termini in most eukaryotes. It elongates
CC telomeres. It is a reverse transcriptase that adds simple sequence
CC repeats to chromosome ends by copying a template sequence within the
CC RNA component of the enzyme. {ECO:0000256|RuleBase:RU365061}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
CC Evidence={ECO:0000256|ARBA:ARBA00024557,
CC ECO:0000256|RuleBase:RU365061};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365061}.
CC Chromosome, telomere {ECO:0000256|RuleBase:RU365061}.
CC -!- SIMILARITY: Belongs to the reverse transcriptase family. Telomerase
CC subfamily. {ECO:0000256|ARBA:ARBA00008001,
CC ECO:0000256|RuleBase:RU365061}.
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DR Ensembl; ENSAPLT00000024751.1; ENSAPLP00000029573.1; ENSAPLG00000004975.2.
DR GeneTree; ENSGT00390000018531; -.
DR Proteomes; UP000016666; Chromosome 2.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003721; F:telomerase RNA reverse transcriptase activity; IEA:InterPro.
DR CDD; cd01648; TERT; 1.
DR Gene3D; 1.10.10.2210; -; 1.
DR Gene3D; 1.10.132.70; -; 1.
DR Gene3D; 1.10.357.90; -; 1.
DR Gene3D; 3.10.10.20; -; 1.
DR Gene3D; 3.30.70.2630; -; 1.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR021891; Telomerase_RBD.
DR InterPro; IPR003545; Telomerase_RT.
DR InterPro; IPR049139; TERT_C.
DR PANTHER; PTHR12066; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR PANTHER; PTHR12066:SF0; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF12009; Telomerase_RBD; 1.
DR Pfam; PF21399; TERT_C; 1.
DR PRINTS; PR01365; TELOMERASERT.
DR SMART; SM00975; Telomerase_RBD; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU365061};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU365061};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365061};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW RNA-directed DNA polymerase {ECO:0000256|RuleBase:RU365061};
KW Telomere {ECO:0000256|ARBA:ARBA00022895, ECO:0000256|RuleBase:RU365061};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365061}.
FT DOMAIN 815..1096
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1293 AA; 146412 MW; 7E9DBB6AD6467D47 CRC64;
MEEGRREGEG RGAAAAPGAA AAGDGGAGGT GSTGGTGGGR PHRNMAGAEP FGAVLGALRG
CYAQVAPLET FVRGLGESGA EKAEVVRDSD AASYGTFVSQ CVVCVPHGAR DIPRPFSLEQ
LSSQSEVISR VMQRLCGKKK KNILTYGYSL LDENSSHFQI MPLSNVYSYL PNTATETMRI
SGLWETLLSR IGDDVMMYLL EHCAIFMLVP PSNCYQVCGQ PIYELISQNV ESAPEFVKQR
LSKHKRSSLL KYMQKRLTFH RQYLSKSRQS KRRQRLEANV SSVRNKTSNN IQSLGSAALE
KQSSSNAGLS ATAPSLKRKL AREQLEVTAK RARLEEKERE EQACNTAPNV NQSIPKRYGT
GCVASRSVSL TKEKNISQRS NSDMSRPSLV HNSHRGKKSV ADKSSFLQGA ESNRHLKPSI
EMQAGSSRKG VETRRPIPRL DWVPIEPAES SSSGHKKQEG PLAHLAEEVP NRVLPSTIYI
DRKFLYSRRY WGERFPKSFL LNRLKGSQAG VKRLIETIFL SQNPFGQKCN QGLPQKKRRK
KKLPKRFWRM RSIFQQLLKN HGKFPYVAFL RQNCPLRISD TILGKAKLLS RAPLPGQAEA
RKQAEQLGKE PAERVASSRC ESGHTNVPSS VRAPLAASAC GEPGGEEQIP AEASDSVLRE
LLKEHCSHFQ VYLFVRECVE RVIPTELWGS NHNKRRFFKN VKAFISMGKY AKLSLQVLMW
KMRVNDCMWL RLAKGNHFVP ASEHLYREEI LAKFLYWLMD TYVVQLLRSF FYVTETMFQK
NMLFYYRKCI WGKLQDIGIR KHFSKVKLRP LTAEEMEAIH QKKYLPMASK LRFIPKVTGL
RPIVRMSGVV EAQTLSKESR AKKMNHYNMQ LKNLFSVLNY ERTINTSYIG SSVFGRDDIY
KSWKTFVKKV LKSDGEIPHF YYVKVSTFKD FMPDMKQFVS RLHESTSLRD AIIVEQSLTF
NETSASLFNF FLQMLNNNIL EIERSYYLQC SGIPQGSLLS TLLCSLCYGD MENKLFSGVQ
KDGVLIRLID DFLLVTPHLT HARTFLRTLA MGIPEYGFLI NPKKTVVNFS ADDIPECSEF
KQLPNCRLIP WCGLLLDTQT LEVYCDYSSY SCTSIRSSLS FNSNRTAGKN MKHKLLAVLK
LKCHGLFLDL QINSLKTVFI NVYKIFLLQA YRFHACVIQL PFNQKVRNNP DFFLRVIAEN
ASCCYSMLKA KNPGFTLGNR GASGMFPSEA AEWLCYHAFT VKLSNHKVVY KCLLKPLKFC
MMQLFRKIPK DTKALLKTVT EPSICKDFKS ILD
//
