ID A0A493TW97_ANAPP Unreviewed; 1540 AA.
AC A0A493TW97;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Cytoplasmic linker associated protein 1 {ECO:0000313|Ensembl:ENSAPLP00000030162.1};
GN Name=CLASP1 {ECO:0000313|Ensembl:ENSAPLP00000030162.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000030162.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000030162.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000030162.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Golgi
CC apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601}.
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DR STRING; 8840.ENSAPLP00000030162; -.
DR Ensembl; ENSAPLT00000044738.1; ENSAPLP00000030162.1; ENSAPLG00000002082.2.
DR GeneTree; ENSGT00940000154817; -.
DR Proteomes; UP000016666; Chromosome 7.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0015631; F:tubulin binding; IEA:InterPro.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:UniProt.
DR GO; GO:1902903; P:regulation of supramolecular fiber organization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF28; CLIP-ASSOCIATING PROTEIN 1; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 1.
DR SMART; SM01349; TOG; 4.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 4: Predicted;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..232
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 168..206
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 319..551
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 858..1088
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1291..1529
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 231..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 828..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1120..1170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1250..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1540 AA; 169616 MW; 8B32A5FA8A8ED668 CRC64;
MEPSMEYCLA QVLQKDVGKR LQVGQELIDY FSDKQKSADL EHDQTMLDKM VDGLATSWVN
SSNYKVVLLG IDILSALVSR LQDRFKAQIG TVLPSLLDRL GDSKDSVREQ DQTLLLKIMD
QAANPQYVWD RMLGGFKHKN FRTREGICLC LIATLNASGA QSLTLSKIVP HICNLLGDPN
SQVRDAAINS LVEIYRHVGE RVRADLSKKG LPQSRLNVIF TKFDEVQKSG NMIQSSGDKN
FDDEDSVDGN RPSSASSSTS SKTPANSRRV GMGTTRRLGS APLGSKSSTA KEGAGAVDEE
DFIKAFEDVP TVQIYSSRDL EESINKIREI LSDDKHDWEQ RVSALKKIRS LLLAGAAEYD
NFFQHLRLLD GAFKLSAKDL RSQVVREACI TLGHLSSVLG NKFDHGAEAI MPTIFNLIPN
SAKVMATSGV VAVRLIIRHT HIPRLIPIIT SNCTSKSVAV RRRCFEFLDL LLQEWQTHSL
ERHISVLAET IKKGIHDADS EARIEARKCY WGFHSHFSRE AEHLYHTLES SYQKALQSHL
KNSDSIVSLP QSDRSSSSSQ ESLNRPLSAK RSPTGSTTSR ASTVSTKSVS TPGSLQRSRS
DVDVNAAASA KSKVTSSGAS TPFSSAAALP PGSYASLGRI RTRRQSSGSA TSVTSTPADT
RGRSRAKVVS QSQRSRSANP AGAGSRSSSP GKLLGSAYGG LSGGTSRVQP VPSSSEKRSK
IPRSQGCSRE TSPNRIGLAR SSRIPRPSMS QGCSRDTSRE SSRDTSPARG FPPLDRFGLG
QPGRMPASVN AMRVLSTSTD LEAAVADALL LGDSRSKKKP VRRRYEPYGM YSDDDANSDA
SSACSERSYG SRNGGIPHYL RQTEDVAEVL NHCASSNWSE RKEGLIGLQN LLKSQRTLSR
VELKRLCEIF TRMFADPHSK VFSMFLETLV DFIIIHKDDL QDWLFVLLTQ LLKKMGADLL
GSVQAKVQKA LDVTRDSFPF DQQFNILMRF IVDQTQTPNL KVKVAILKYI ESLARQMDPT
DFVNSSETRL AVSRIITWTT EPKSSDVRKT MHSWVGEDLP ARTTAASSGP GEGNLEEKCK
QAAQIVLISL FELNTPEFTM LLGALPKTFQ DGATKLLHNH LKNSSNTSVG SPSNTLGRTP
SRHSSSRTSP LTSPTNCSHG GLSPSMLDYD TENLNSDEIY SSLRGVTEAI EKFSFRSQED
LNEPIKRDGK KDCDIVSRDG GLAVPSSDVR GSSDIVEGGR MALDNKTSLL NTQPPRAFSG
PRAREYNPYP YSDTINTYDK TALKEAVFDD DMDQLRDVPI DHSDLVADLL KELSNHNERV
EERKGALLEL LKITREDNLG VWEEHFKTIL LLLLETLGDK DHSIRALALR VLREILRNQP
ARFKNYAELT IMKTLEAHKD SHKEVVRAAE EAASTLASSI HPEQCIKVLC PIIQTADYPI
NLAAIKMQTK VIERISKESL HQLLPDIIPG LLQGYDNTES SVRKASVFCL VAIYSVIGEE
LKPHLAQLTG SKMKLLNLYI KRAQTTNSNS SSSSDVSTHS
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