ID A0A493TXG8_ANAPP Unreviewed; 933 AA.
AC A0A493TXG8;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Glutamate metabotropic receptor 7 {ECO:0000313|Ensembl:ENSAPLP00000030582.1};
GN Name=GRM7 {ECO:0000313|Ensembl:ENSAPLP00000030582.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000030582.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000030582.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000030582.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; A0A493TXG8; -.
DR Ensembl; ENSAPLT00000037672.1; ENSAPLP00000030582.1; ENSAPLG00000002555.2.
DR GeneTree; ENSGT01030000234648; -.
DR Proteomes; UP000016666; Chromosome 13.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15286; 7tmC_mGluR_group3; 1.
DR CDD; cd06376; PBP1_mGluR_groupIII; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001883; GPCR_3_mGluR7.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF98; METABOTROPIC GLUTAMATE RECEPTOR 7; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01057; MTABOTROPC7R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..50
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 51..933
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019784728"
FT TRANSMEM 606..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 676..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 770..791
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 803..825
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 606..831
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 933 AA; 103636 MW; FD40951FCB40D9D3 CRC64;
MKAQGSGGHR PGGGGGAGTM VRLGRLLRLL TLLKLPCCLL ELLLSEAARG QEMYAPHSIR
LEGDITLGGL FPVHAKGPPG VPCGDIKKEN GIHRLEAMLY ALDQINSDPE LLPNVTLGAR
ILDTCSRDTY ALEQSLTFVQ ALIQKDTSDV RCTNGEPPVF VKPEKVVGVI GASGSSVSIM
VANILRLFQI PQISYASTAP ELSDDRRYDF FSRVVPPDSF QAQAMVDIVK ALGWNYVSTL
ASEGNYGEKG VESFMQISRE AGGLCIAQSL KIPQDRKDKT IDFDKIIKQL LETPNARAIV
IFANDEDIKQ ILAAAKRADQ VGHFLWVGSD TWGSKVSPLL QQEDVAEGAI TILPKRATIE
GFDAYFTSRT LENNRRNVWF AEYWEENFNC KLTISGSKKE DTDRKCTGQE RIGKDSHYEQ
EGKVQFVIDA VYAMAHALHH MNKDLCADYP GVCPEMEHAG GKKLLKYIRS VNFNGSAGTP
VMFNKNGDAP GRYDIFQYHT TNTSTPGYRL VGQWTDDLQL NIDEMQWGKG VREIPSSVCS
LPCKPGERKK MVKGMPCCWH CELCDGYQYQ ADEVTCLLCS YNERPNENRT GCRSIPIVKL
EWHSPWAVIP VFLAMLGIIA TIFVMATFIR YNDTPIVRAS GRELSYVLLT GIFLCYIITF
LMIAKPNVAV CSFRRIFLGL GMCISYAALL TKTNRIYRIF EQGKKSVTAP RLISPTSQLA
ITSSLISVQL LGVFIWFAVD PPNIIIDYDE QKTMNPDQAR GVLKCDITDL QIICSLGYSI
LLMVTCTVYA IKTRGVPENF NEAKPIGFTM YTTCIVWLAF IPIFFGTAQS AEKVGDQESL
SLQLDVGRSL ATTSSSPSTT LGSAAGHSFH HHAVQNTRED ESKRRQLFIL FQRRRCTEDH
ASNSTILAKR LFGWHILLCQ ITTSKRQQNS ESS
//
