ID A0A493TXZ7_ANAPP Unreviewed; 1981 AA.
AC A0A493TXZ7;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000030768.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000030768.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000030768.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR Ensembl; ENSAPLT00000024623.1; ENSAPLP00000030768.1; ENSAPLG00000009692.2.
DR GeneTree; ENSGT00940000154992; -.
DR Proteomes; UP000016666; Chromosome 2.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR008053; Na_channel_a5su.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF288; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR PRINTS; PR01666; NACHANNEL5.
DR SMART; SM00015; IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 125..147
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 191..212
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 224..245
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 251..270
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 386..414
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 726..744
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 756..779
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 791..815
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 836..869
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 924..949
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1172..1190
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1211..1227
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1239..1258
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1303..1323
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1413..1436
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1495..1513
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1525..1547
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1559..1578
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1626..1648
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1715..1738
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 128..420
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 505..675
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 725..955
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 963..1166
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1170..1445
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1494..1748
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 461..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1928..1950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 411..445
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 478..499
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1981 AA; 225380 MW; 5C3A7CE11B2EADDE CRC64;
MADFLLPPGT NSFHRFTPES LAAIEKRIAE KFARNAKQEY REQLGEEEKP QPQFDLQACK
KLPDIYGTVP PELIGEPLED IDPFYNDRKT FVVLNKGKTI FRFSATPALY ILSPFHPIRR
AAIKILVHSL FSMFIMCTIL TNCVFMAQSE TPPWNKYVEY TFTGIYTFES LIKILARGFC
MTEFTFLRDP WNWLDFSVIV MAYITEFVDL GNVSALRTFR VLRALKTISV ISGLKTIVGA
LIQSVKKLAD VMILTVFCLS VFALIGLQLF MGNLRHKCVR DYTMFNSTNG TFYLDGRTWN
SSEEFLNDPV NYFIKNGTED VLLCGNSTDA GTCPEGYICL KAGENPDHGY TSFDTFGWAF
LSLFRLMTQD YWERLYQQTL RSAGKIYMLF FMLVIFLGSF YLVNLILAVV AMAYEEQNQA
TIAETEEKER KFREAMEMLK KEQEALAAKG IDSMSLSSLE MSPLASKNAK ERRNRRKKKK
SSGEEYGEDQ RNPKCEYDDG QRRMTLLGIS YGPNANLVKR RTSHGSIFSF RLRGRDTGSE
TDFADDEIST AGENESHRGS LLIPRSGRRP SVQSQVSHSS HPTTPNYTQT GKRNSSVDCN
GVVSLIGGGT GALNPDPTSP AGLLLPPVIM EKPGTGDLTS PSDEASKKQL LMPHRPSVDH
SDEPFQRQRA VSAVSIITSA LEELEESHQK CPPCWNHFAV KFLIWDCCPL WLLIKKFVKF
VVMDPFTDLT ITLCIVLNTL FMALEHYKMT KEFDHMLYIG NLVFTGIFTA EMIFKVIALD
PYYYFQQGWN IFDSIIVILS LMELGLSSMG NLSVLRSFRL LRVFKLAKSW PTLNTLIKII
GNSVGALGNL TLVLAIIVFI FAVVGMQLFG KSYMDNVKKI STTGNLPRWH MNDFFHSFLI
IFRILCGEWI ETMWDCMEVA GQPLCLLVFL LVMVIGNLVV LNLFLALLLS SFSADNLSAP
DEDGEMNNLQ LAFARINRGL QYVKRTTWDF CCNVLRHPKT TAEKKAMMKL AAQNTGALNN
CVNSHTTAEF GKDMENHKEN HTEDGMNKNG DKHLGITDND DFMTNPDLSI CVPIAVGESD
IEEEDEEQST FTEMEQLDEI SLSEGSTVDL TNPAELLEQI PEFAEELMEP EDCFPEVCVR
FFPCCSVDIS KFPGKIWWRL RKTCYRIVEH NWFETFIIFM ILLSSGALAF EDIYLEDRKN
IKTMLEYADK IFTYIFVLEM LLKWVAYGFK KYFTNAWCWL DFLIVDVSLI SLIANTLGYS
EMGPIKSLRT LRALRPLRAL SRFEGMRVVV NALVGAIPSI MNVLLVCLIF WLIFSIMGVN
LFAGKFGKCI NKTEGDMPLD SKIINNMSDC ILYNVSGTFY WTKVKVNFDN VGAGYLALLQ
VATFKGWMDI MYAAVDSREC EEQPEWECNL YMYLYFVIFI IFGSFFTLNL FIGVIIDNFN
QQKKKLGGQD IFMTEEQKKY YNAMKKLGSK KPQKPIPRPL NKYQGFIFDV VSKQAFDVSI
MILICLNMVT MMVETDDQSQ EKVNILHKIN MLFVAIFTGE CIIKMLALRH YYFTNGWNIF
DFVVVILSIV GTVLSDIIQK YFFSPTLFRV IRLARIGRIL RLIRGAKGIR TLLFALMMSL
PALFNIGLLL FLVMFIYAIF GMANFAYVKK EYGIDDMFNF QTFANSMLCL FQITTSAGWD
GLLNPILNTG PPYCDPNLPN ANGSKGDCGS PAVGILFFVT YIIISFLIVV NMYIAIILEN
FSVATEESTE PLSEDDFDMF YEIWEKFDPE ATQFIEYSAL SDFADALSEP LRIAKPNKIK
LIAMDLPMVS GDRIHCLDIL FAFTKRVLGE SGEMDALKIQ MEEKFMAANP SKISYEPITT
TLRRKQEEVS AIVIQRAYRR HLFRRSMKQA SYLYRHRTFD GSILEDDAPE KEGLIAFMMN
ENYGRPIDKS ETLSSTSFPP SYDSVTRGTS ENLQLKLTDS SKSDEAIDCL LSPDRDKESI
V
//
