ID A0A493TY07_ANAPP Unreviewed; 1044 AA.
AC A0A493TY07;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Semaphorin 6A {ECO:0000313|Ensembl:ENSAPLP00000030746.1};
GN Name=SEMA6A {ECO:0000313|Ensembl:ENSAPLP00000030746.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000030746.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000030746.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000030746.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR AlphaFoldDB; A0A493TY07; -.
DR STRING; 8840.ENSAPLP00000030746; -.
DR Ensembl; ENSAPLT00000034437.1; ENSAPLP00000030746.1; ENSAPLG00000014502.2.
DR GeneTree; ENSGT00940000156565; -.
DR Proteomes; UP000016666; Chromosome Z.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; IEA:Ensembl.
DR GO; GO:0106089; P:negative regulation of cell adhesion involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:1900747; P:negative regulation of vascular endothelial growth factor signaling pathway; IEA:Ensembl.
DR CDD; cd11266; Sema_6A; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF12; SEMAPHORIN-6A; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1044
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019737151"
FT TRANSMEM 662..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..512
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 772..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 874..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 934..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 993..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..918
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 934..973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 993..1015
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1044 AA; 116153 MW; 278BA19336B5E0CF CRC64;
MRSEALLLYF TLLHFAGAGF PEDSEPISIS HGNYTRQYPV FVGHKPGRNT TQRHRLDIQL
VMVMNRTLYV AARDHIYTVD MDTSHTEEIY FSKKLTWKSR QADVDTCRMK GKHKDECHNF
IKVLLKRNED TLFICGTNAF NPSCRNYKMD TLEFLGDEFS GMARCPYDAK HANVALFAEG
KLYSATVTDF LAIDAVIYRS LGDSPTLRTV KHDSKWLKEP YFVQAVDYGN YIYFFFREIA
VEYNSMGKVV FPRVAQVCKN DMGGSQRVLE KQWTSFLKAR LNCSVPGDSH FYFNILQAVT
DVIHFNGRDV VLATFSTPYN SIPGSAVCAY DMLDIANVFT GRFKEQKSPD STWTPVPDER
VPKPRPGCCA GSTSLEKYVT SNEFPDDTLN FIKTHPLMDE AVPSIVNRPW FLRTMVRYRL
TKIAVDSAAG PYQNYTVVFL GSEKGIILKF LARTGNSGFL NDSLFLEEMN VYNPEKCSYD
GVEDKRIVGM QLDKPSSALY VAFSTCVIKV PLGRCERHGK CKKACIASRD PYCGWVKESG
VCTQLVLGAK LAFEQDIEHG NTDGLGDCQN SFVALNDIST ASPDHEMSYD TVYGHSSSLV
PSTTSSNSRA RQGYDARGRM LDWKDPLGSS ENTDPYVAVS SHNHQDKKGV IRESYLKGHD
QLVPVTLLAI AVILAFVMGA VFSGIIVYCI CDHRRRDVAV VQRKEKELTH SRRGSMSSVT
KLSGLFGDAQ SKEPKPEAIL TPLMHNGKLA TPGSTAKMLI KADQHHLDLA ALPTPESTPT
LQQKRKPSRG SREWERNQNL INACTKDIPP MASPVIPTDL PLRASPSHIP SVVVLPISQQ
GYQHEYVDQP KMSDGAQMSV EDQNATLEYK TIKDHLSSKS PSHGVNLVES LDSMPPKVPQ
REASLGPPST SLSQSGLSKR LEMHSSAYSV DYKRNYPTNS LTRSHQASTL KRNNTNSSNS
SHLSRNQSFG RGDNPPPAPQ RVDSIQVHAA QAQAVTVSRQ PSLTAYNSLT RSGLKRTPSL
KPDVPPKPSF APLSTSMKPN DACT
//
