ID   A0A493TYT5_ANAPP        Unreviewed;      1093 AA.
AC   A0A493TYT5;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=BUB1 mitotic checkpoint serine/threonine kinase B {ECO:0000313|Ensembl:ENSAPLP00000030740.1};
GN   Name=BUB1B {ECO:0000313|Ensembl:ENSAPLP00000030740.1};
OS   Anas platyrhynchos platyrhynchos (Northern mallard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000030740.1, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000030740.1, ECO:0000313|Proteomes:UP000016666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT   "A new Pekin duck reference genome.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000030740.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A493TYT5; -.
DR   Ensembl; ENSAPLT00000036594.1; ENSAPLP00000030740.1; ENSAPLG00000004271.2.
DR   GeneTree; ENSGT00940000158912; -.
DR   Proteomes; UP000016666; Chromosome 5.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR   Gene3D; 1.25.40.430; -; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR015661; Bub1/Mad3.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR013212; Mad3/Bub1_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   PANTHER; PTHR14030; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1; 1.
DR   PANTHER; PTHR14030:SF25; MITOTIC CHECKPOINT SERINE_THREONINE-PROTEIN KINASE BUB1 BETA; 1.
DR   Pfam; PF08311; Mad3_BUB1_I; 1.
DR   SMART; SM00777; Mad3_BUB1_I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51489; BUB1_N; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT   DOMAIN          69..236
FT                   /note="BUB1 N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51489"
FT   DOMAIN          827..1093
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          218..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          303..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          457..485
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          499..518
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        318..339
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        467..485
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1093 AA;  123235 MW;  74120493A318BAE1 CRC64;
     MYRYLTVFAL NAEFKGEAVM SQDCNDEWEL SKENVQPLKQ GRVMSTLQEA LAQQEASTHT
     AVQLKKQEFE SEIRFYSGDD PLDVWDRYIK WTEQTFPQGG KESNLSAVLE RAVRALNEEK
     RYYKDPRYLN LWLKFGNCCN EPLDLYSYLH SQEIGTTLAL LYITWAEELE ARGSFKKADL
     IFQEGLNRKA EPLDKLQSHH RQFQTRVSRQ TLLGLEEDTD ERDTSLLGTE EPQRSSLADL
     KGRGKKKVRA PISRVGDALK ATNQNRSLQT LTSQQLSKNP GFAVFDENST LASGPEIPVL
     TPQSWAAPPV PRAKENEQSA GPWNSGRRPH SSANSGIEMP CPMTSFTPYV EESSQQQVMT
     PCKIDPSINS VLSARKPQKE EDPLWRVQNQ RLDSQEKEMV MYCKDKVYAG VEEFSLEEIR
     AEVYRKKAKK KAEEEFQAIM QKKEEIQRKI EALEKKLKEK KGDKQQQQSC EQPTEITKPL
     PSLGQEELTF SSATELGVRE PRLESEYQPS EDIKLHKPSC SEEVIQSLDV CPDTRRGSVF
     LSSEDEQEEQ RDKASLGKRE KFEDVVFLPS TYPSMPFSIF DESSTSANQN ISCSTDNTKK
     SARCPLAVRK PSESATAKEN VPPEACDELN GIEPLSEDAI VTGSYKNKTL CANPEDTCDF
     VRAAHLASTP FHGVLAQRIP DPAYSQSVLK EDCPESKSAP PNQNTPVCEG TYNEVLSVNK
     LSPIMEASLE DTRSSGSSVS SGSSLSSVTQ ISTIKYLHIP EKLELAQTLP AETITDSGGI
     SENITGDVTP LLWSAEQHKK LLDPMPESLT ASPDFHLETG SMPVMEFEKD IKLGDETYSI
     KWEYWTNEEH KMFFVTLANF AQLDAKGFVT KVYSQPVPWD FYITLQLRER LNTDFDQSFS
     ENCSCFLYQD GCVILHRDVN RFTLADLIRG CKSIAKEFIL LVVHDLLSVV EKLHKAEIVH
     GDLRPEVLFL GDSICDLLGY DKVTGALKVV DFSHSVDLRL QSQVSLPNNF PISQTPHGQQ
     LLAKSSLPYQ VDLVGIADIV HLMLFGDHIQ VCQENSIWKI SQNISEDQKE ETVRRQDGPT
     RLCCRCVLFS FGT
//