ID   A0A493U167_ANAPP        Unreviewed;      1102 AA.
AC   A0A493U167;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Folliculin interacting protein 2 {ECO:0000313|Ensembl:ENSAPLP00000031873.1};
GN   Name=FNIP2 {ECO:0000313|Ensembl:ENSAPLP00000031873.1};
OS   Anas platyrhynchos platyrhynchos (Northern mallard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000031873.1, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000031873.1, ECO:0000313|Proteomes:UP000016666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT   "A new Pekin duck reference genome.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000031873.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004656}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the FNIP family.
CC       {ECO:0000256|ARBA:ARBA00007541}.
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DR   AlphaFoldDB; A0A493U167; -.
DR   Ensembl; ENSAPLT00000026909.1; ENSAPLP00000031873.1; ENSAPLG00000015049.2.
DR   GeneTree; ENSGT00390000009391; -.
DR   Proteomes; UP000016666; Chromosome 4.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR037545; DENN_FNIP1/2.
DR   InterPro; IPR028086; FNIP_C_dom.
DR   InterPro; IPR026156; FNIP_fam.
DR   InterPro; IPR028085; FNIP_mid_dom.
DR   InterPro; IPR028084; FNIP_N_dom.
DR   PANTHER; PTHR21634:SF11; FOLLICULIN-INTERACTING PROTEIN 2; 1.
DR   PANTHER; PTHR21634; UNCHARACTERIZED; 1.
DR   Pfam; PF14638; FNIP_C; 1.
DR   Pfam; PF14637; FNIP_M; 1.
DR   Pfam; PF14636; FNIP_N; 1.
DR   PRINTS; PR02073; FOLLICULNIP1.
DR   PROSITE; PS51836; DENN_FNIP12; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT   DOMAIN          37..1093
FT                   /note="UDENN FNIP1/2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51836"
FT   REGION          194..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          665..715
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          840..887
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        194..218
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        695..710
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1102 AA;  122248 MW;  6381B93F8C5A3413 CRC64;
     MAPTLLQKLF HKRGGGGGAA APGGREGPAF SWSSSEFDLN EIRLIVYQDC ERRGRQVLFD
     STAVRKIDEA VIQKMAEDAA VKASVKNCQA GNGNNISSHS PSISCLQNIR EQIPKYQYTR
     PASDVNMLGE MMFGSVAMSY KGSTLKIHYI RSPPQLMISK VFSARVGSFS GSNNNLQDSF
     EYINQDSSLG KLNSNQNGLG TCRSGSNLAH STPVDMPSRG QNEDRDSGIA RSASLSSLLV
     TPFPSPSSSS SSSSSYQRRW LRSQTTSLEN GIIPRWSTEE MFSMADESCS SNPAMVRRKK
     IAISIIFSLP EKEEAQRNFQ DFFFSHFPLF ESHMNKLKYA IEKAMISCRK IAESSQRVQV
     YISRVMDALG EFRITIWNLY SVPRIAEPVW LNMMSNTLEK NQLCQRFLKE FTFLIEQINK
     NQFFAALLTA VLTYHLAWVP TVMPVDHPPI KAFSEKRTSQ FVNMLAKSHP YNPLWAQLGD
     LYGAIGSPVR LTRTVIVGKR KELVQRLLYV LTYFIRCSEL QENQLTWSEV LGEGEQVLNG
     SKITTALEKG EVEESDYVVV TVKNEPALVP PILPPKSDGS KNNSIAGWVH NPEGTCTTTD
     SSKEKEAIGK VSQNSDTAVD CLTSTLHNGA ADGRKRTVTD TGTGSYHFEE QSKLENLMDV
     RKNKNQNERK VEKQLSSRSS ALPCPERSGR RSSQLEKVTF RIGSSASPES DLETQRREME
     ENLKAFRKNP EVVIHCASSS ADLTVDVSQN QKESCEAAFL PFSKHSICYA QIPPCEGKES
     MLNNQHMETK GTEMNLGNTV SGELLLSTDN VETVTLPSLK ETRTLCSGNP ESCSPDCVEG
     GSAVRKESPK VGAKDVPYGD AGRKTPFRVE GDIPRNESSD SALGASDEEG DCCIPDEVHH
     DNVSKRLEEF VEVELPLPRS NTISSQCVKN FGRSLLGGYC HTYVPDLVLH GVNNDEKLKQ
     CLLADLLHAM HHPVLDEPIA EAVCIIADTD KWNVQVATSQ RKMMDNVKLG KDVLVSSQVS
     SLLQSILQLY KLNLPADFCI MHLEDRLQEM YLKSKMLSEY LRGHTRVHVK ELGIVLGIES
     NDLPLLAAIA STHSPYVAQI LL
//